Thyroliberinase
Thyrotropin-releasing hormone-degrading ectoenzyme | ||
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other names |
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Properties of human protein | ||
Mass / length primary structure | 117 kilodaltons / 1,024 amino acids | |
Identifier | ||
Gene names | TRHDE PAP-II; PGPEP2; TRH-DE | |
External IDs | ||
Enzyme classification | ||
EC, category | 3.4.19.6 | |
Orthologue | ||
human | House mouse | |
Entrez | 29953 | 237553 |
Ensemble | ENSG00000072657 | ENSMUSG00000050663 |
UniProt | Q9UKU6 | Q8K093 |
Refseq (mRNA) | NM_013381 | NM_146241 |
Refseq (protein) | NP_037513 | NP_666353 |
Gene locus | Chr 12: 72.09 - 72.67 Mb | Chr 10: 114.4 - 114.8 Mb |
PubMed search | 29953 |
237553
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The Thyroliberinase (also TRH-Degrading-ectoenzymes or TRH-DE) is a metallopeptidase , whose only known substrate the thyrotropin-releasing hormone is (TRH).
Thyroliberinase is an ectoenzyme that is expressed on lactotropic cells of the adenohypophysis and tanycytes (specialized glial cells of the hypothalamus). The regulation is carried out by a triiodothyronine (T3) -dependent feedback regulation.
Individual evidence
- ↑ a b Löffler / Petridas: Biochemistry and Pathobiochemistry . 9th edition. Springer-Verlag, Berlin 2014, ISBN 978-3-642-17972-3 , pp. 513 .