Toxin BoP1
| Potassium channel toxin alpha-KTx 16.8 | ||
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| other names |
Toxin BoP1 |
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| Mass / length primary structure | 36 amino acids , 4,099 Da | |
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Toxin BoP1 (synonym potassium channel toxin alpha-KTx 16.8 ) is a toxin from the scorpion Buthus occitanus Paris (field scorpion).
properties
Toxin BoP1 is a protein and scorpion toxin from the field scorpion, as well as BoPKTX and toxin BoP2 . It binds to synaptosomes of rats with an IC 50 >> 100 nM . Toxin BoP1 binds weakly to the potassium channel Kv1.3 . Presumably it binds to KCa1.1 / KCNMA1 . It is structurally related to martentoxin .
Web links
Individual evidence
- ^ A b M. F. Martin-Eauclaire, B. Céard, M. Belghazi, R. Lebrun, PE Bougis: Characterization of the first K⁺ channel blockers from the venom of the Moroccan scorpion Buthus occitanus Paris. In: Toxicon: official journal of the International Society on Toxinology. Volume 75, December 2013, pp. 168-176, doi : 10.1016 / j.toxicon.2013.03.004 , PMID 23523531 .