Trehalase
| Trehalase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 533 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Precursor | (560 aas) | |
| Isoforms | 2 | |
| Identifier | ||
| Gene name | TREH | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.2.1.28 , glycosidase | |
| Response type | hydrolysis | |
| Substrate | α, α-trehalose + H 2 O | |
| Products | 2 D-glucose | |
| Occurrence | ||
| Homology family | Trehalase | |
| Parent taxon | Creature | |
Trehalase ( gene : TREH ) is the name of the enzyme that breaks down trehalose into glucose . Since trehalose is one of the most important reserves (except in mammals), the enzyme is important for their digestion. Trehalase occurs in many living things. In humans it is localized in the small intestine . Trehalase deficiency due to mutations in the TREH gene occurs particularly in Greenland Inuit (10 to 15%) and leads to the inability to digest trehalose, and thus to severe flatulence after mushroom dishes.
In insects in particular, trehalose is the main reserve sugar, and inhibition of trehalase can lead to death due to hypoglycemia, which is used in insect control.
Trehalase in the urine can indicate poisoning with cadmium and copper, as it is also expressed in the microtubules of the kidneys.
Individual evidence
- ↑ Trehalase. In: Online Mendelian Inheritance in Man . (English).
- ↑ Wegener G, Tschiedel V, Schlöder P, Ando O: The toxic and lethal effects of the trehalase inhibitor trehazolin in locusts are caused by hypoglycaemia . In: J. Exp. Biol. . 206, No. Pt 7, April 2003, pp. 1233-1240. PMID 12604583 .
- ↑ Skoczyńska A, Martynowicz H, Poreba R, Antonowicz-Juchniewicz J, Sieradzki A, Andrzejak R: [Urinary trehalase activity as an indicator of renal dysfunction in lead smelters] . In: Med Pr . 52, No. 4, 2001, pp. 247-252. PMID 11761669 .
- ↑ Ishihara R, Taketani S, Sasai-Takedatsu M, et al : ELISA for urinary trehalase with monoclonal antibodies: a technique for assessment of renal tubular damage . In: Clin. Chem. . 46, No. 5, May 2000, pp. 636-643. PMID 10794745 .