Tspan-27
CD82 antigen | ||
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other names |
C33 antigen, IA4, Inducible membrane protein R2, Metastasis suppressor Kangai-1, Suppressor of tumorigenicity 6 protein, Tetraspanin-27, Tspan-27 |
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Properties of human protein | ||
Mass / length primary structure | 267 amino acids , 29,626 Da | |
Identifier | ||
External IDs | ||
Orthologue (human) | ||
Entrez | 3732 | |
Ensemble | ENSG00000085117 | |
UniProt | P27701 | |
Refseq (mRNA) | NM_001024844.1 | |
Refseq (protein) | NP_001020015.1 | |
PubMed search |
3732
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Tspan-27 (synonymous CD82 ) is a surface protein from the group of tetraspanins and a tumor suppressor .
properties
Tspan-27 is made by lymphocytes . It is used to sort membrane proteins by structuring areas of the cell membrane. It reduces the metastasis and progression of tumors . Metastasis is inhibited by inhibiting motility , promoting cell polarity and initiating senescence and apoptosis as a reaction to certain extracellular signaling molecules. Tspan-27 regulates the composition of microdomains and the surface area in the cell membrane . It's glycosylated . Tspan-27 binds to CD19 , CD63 and CD234 .
Web links
Individual evidence
- ^ M. Thali: Tetraspanin functions during HIV-1 and influenza virus replication. In: Biochemical Society transactions. Volume 39, number 2, April 2011, pp. 529-531, doi : 10.1042 / BST0390529 , PMID 21428933 , PMC 4067976 (free full text).
- ↑ YC Tsai, AM Weissman: Dissecting the diverse functions of the metastasis suppressor CD82 / KAI1. In: FEBS letters. Volume 585, Number 20, October 2011, pp. 3166-3173, doi : 10.1016 / j.febslet.2011.08.031 , PMID 21875585 , PMC 3409691 (free full text).
- ↑ J. Feng, C. Huang, JD Wren, DW Wang, J. Yan, J. Zhang, Y. Sun, X. Han, XA Zhang: Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity. In: Cancer metastasis reviews. Volume 34, Number 4, December 2015, pp. 619-633, doi : 10.1007 / s10555-015-9585-x , PMID 26335499 .
- ↑ T. Imai, M. Kakizaki, M. Nishimura, O. Yoshie: Molecular analyzes of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. In: Journal of Immunology. Volume 155, Number 3, August 1995, pp. 1229-1239, PMID 7636191 .
- ↑ G. Horváth, V. Serru, D. Clay, M. Billard, C. Boucheix, E. Rubinstein: CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82. In: The Journal of biological chemistry. Volume 273, Number 46, November 1998, pp. 30537-30543, PMID 9804823 .
- ↑ C. Hammond, LK Denzin, M. Pan, JM Griffith, HJ Geuze, P. Cresswell: The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. In: Journal of Immunology. Volume 161, Number 7, October 1998, pp. 3282-3291, PMID 9759843 .
- ↑ Jin Hur, Jae-Il Choi, Hwan Lee, Pniel Nham, Tae-Won Kim, Cheong-Whan Chae, Ji-Yeon Yun, Jin-A. Kang, Jeehoon Kang: CD82 / KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages . In: Cell Stem Cell . 18, No. 4, April 7, 2016, ISSN 1875-9777 , pp. 508-521. doi : 10.1016 / j.stem.2016.01.013 . PMID 26996598 .