Tumor metabolome

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The term tumor metabolome describes the characteristic metabolic phenotype (= the metabolome ) of tumor cells .

The conversion of normal cells into tumor cells is associated with drastic changes in the metabolism of the cells.

Intensive metabolic characterizations (metabolome analyzes) of different tumor cell lines and tumors have shown that the same metabolic changes always occur with certain metabolic parameters during tumor development.

These are changes in metabolism

  • regardless of the metabolic status of the original tissue from which the respective tumor developed, such as liver and brain and
  • independent of the molecular mechanisms by which the tumor development was induced.

The characteristic metabolic properties of the tumor metabolome are:

  • high activities in the glycolysis - enzymes
  • the expression of the pyruvate kinase isoenzyme type M2, which is predominantly in the dimeric form (= tumor M2-PK )
  • high phosphometabolite levels
  • a pronounced channeling of the glucose carbon atoms in synthesis processes such as nucleic acid, phospholipid and amino acid synthesis
  • a high pyrimidine - and purine - de novo -Syntheserate
  • high fatty acid - de novo -Syntheserate
  • a low (ATP + GTP): (CTP + UTP) ratio
  • a high glutaminolysis capacity
  • the release of immunosuppressive substances
  • a pronounced methionine dependence

swell

  • S. Mazurek, H. Grimm, CB Boschek, P. Vaupel, E. Eigenbrodt: Pyruvate kinase type M2: a crossroad in the tumor metabolome . In: Brit. J. Nutr. 87, (2002), pp. 23-29. PMID 11895152 (English)
  • S. Mazurek, E. Eigenbrodt: The tumor metabolome . In: Anticancer Res . 23, (2003), pp. 1149-1154. PMID 12820363 (English)

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