Udo Ehling

Udo Ehling (1960)

Udo Horst Ehling (born August 27, 1928 in Zehdenick , † August 8, 2010 in Berlin ) was a German geneticist.

Life

Udo Ehling grew up in Zehdenick on the Havel in the Mark Brandenburg. In the winter semester of 1949/50 he began studying biology and zoology at the Free University of Berlin . From November 1952 he worked at the Max Planck Institute for Comparative Hereditary Biology and Hereditary Pathology in Berlin-Dahlem.

In 1956 he received his doctorate with the thesis: Investigations into the hereditary cataract genesis in rabbits with special consideration of the experimental influence of the phenogenesis . From 1955 to 1962 Ehling was Hans Nachtsheim's scientific assistant at the Max Planck Institute for Comparative Hereditary Biology and Hereditary Pathology. In 1959/60 he was awarded the US Public Health International Fellowship and went to the "Mouse House" of the National Laboratory in Oak Ridge (ORNL), Tennessee (USA), under the direction of Alexander Hollaender , Liane B. Russell and William L. Russell . He was employed in Oak Ridge until the summer of 1961.

From 1961 to 1963 Ehling was head of the laboratory for genetics in the Institute for Radiation Research at the experimental and training facility for radiation protection in Neuherberg near Munich, which later became the Society for Radiation Research (GSF), under the direction of Otto Hug . In 1963 Ehling went back to Oak Ridge and was the first to carry out experiments with chemical mutagens. The following year he was made an Honorary Citizen of Tennessee State. In 1968 he returned to Germany as head of the independent department for genetics at the Institute for Biology of the Society for Radiation Research and in 1970 carried out the founding congress of the "European Environmental Mutagen Society" (EEMS) in Neuherberg. Since the beginning of the 1970s, a “Big Biology” based on the Oak Ridger model has been set up.

Interior Minister Hans-Dietrich Genscher appointed Ehling to the federal government's radiation protection commission. In 1978 he became head of the department for genetics and executive director of the institute for biology of the extended society for radiation and environmental research. Ehling was Vice President (1979–1981) and President of the European Environmental Mutagen Society (1981–1983). Since 1969 he has been a lecturer at the Technical University of Munich , where he habilitated cumulatively in medicine in 1982 with the Venia Legendi for genetics, was appointed adjunct professor in 1989 and gave lectures on human genetics and mutation research. From 1986 until his retirement in 1993, Ehling was director of the Institute for Mammalian Genetics at the GSF.

Ehling's estate, including his memories from 1928 to 1993, is in the Bayerisches Hauptstaatsarchiv (Sig .: "Bayerisches Hauptstaatsarchiv NL Ehling").

plant

Ehling is a pioneer in the field of mutagenicity testing and quantification of the genetic risk as a result of the influence of ionizing radiation and chemical substances on the human genome. His concept of direct genetic risk estimation was adopted by the United Nations Scientific Committee in the Effects of Atomic Radiation (UNSCAER) in 1977. The radiation-induced mutations to be expected after the Chernobyl reactor accident are estimated in: Strahlentherapie und Onkologie 163, 1987, pp. 283-291. There are over 230 publications, mainly in English.

Fonts

• with RB Cumming and H. Malling, Induction of dominant lethal mutations by alkylating agents in male mice , Mutation Research 5, 1968, pp. 417-428.
• Mutagenicity test method I – IV, GSF report B 564 / B 565 / B 630 / B 667, 1975/1977.
• with J. Favor, J. Kratochvilova, A. Neuhäuser-Klaus, Dominant cataract mutions and specific-locus mutations in mice induced by radiation or ethylnitrosourea , Mutation Research 92, 1982, pp. 181-192.
• with DJ Charles, J. Favor, J. Graw, J. Kratochvilova, A. Neuhauser-Klaus, W. Pretsch, Induction of gene mutations in mice: The multiple endpoint approach , Mutation Research 150, 1985, pp. 393-401.
• Germ-cell mutations in mice: Standards for protecting the human genome , Mutation Research 212, 1989, pp. 43-53.
• with A. Neuhäusser-Klaus, Dominant lethal test with mice , in: R. Fahrig (ed.), Mutationsforschung und genetic toxicology , Darmstadt 1993, pp. 299–309.
• this., The specific locus test with mice , in: R. Fahrig (ed.), Mutationsforschung und genetic Toxikologie , Darmstadt 1993, pp. 309-320.

Awards

• 1994: Prize of the Society for Environmental Mutation Research

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• Chr. Reuter-Boysen, From radiation to environmental research: History of the GSF 1957–1972 ( studies on the history of major German research institutions 5), Frankfurt am Main et al. 1992.
• A. von Schwerin, Experimentalization of Man. The geneticist Hans Nachtsheim and the comparative hereditary pathology 1920–1945 ( History of the Kaiser Wilhelm Society in National Socialism 10), Göttingen 2004.
• LB Russell, The Mouse House: A brief history of the ORNL mouse-genetics program, 1947-2009 , Mutation Research 753, 2013, pp. 69-90.
• A. v. Schwerin, From Agriculture to Genomics: The Animal Side of Human Genetics and the Organization of Model Organisms in the Longue Durée , in: B. Gausemeier, St. Müller-Wille, E. Ramsden (eds.), Human Heredity in the Twentieth Century ( Studies for the Society for the Social History of Medicine 15), London 2013, pp. 113–125.

Individual evidence

1. ↑ Ilse-Dore Adler, Jack Favor: Memorial for Udo H. Ehling (1928-2010). In: Environmental and Molecular Mutagenesis. Vol. 52, Iss. 3, April 2011, p. 171–173, doi: 10.1002 / em.20640 .