Verdoglobin
Verdoglobin or sulfhemoglobin is an organic chemical compound and belongs to the group of cyclic tetrahydropyrroles, it contains sulfur and a hemoglobin ring system. Felix Hoppe-Seyler called it sulfur hemoglobin . According to the nomenclature of gravels and Kaeske is the name Verdoglobin S .
Sulfhemoglobin is a relatively stable, nonfunctional hemoglobin derivative that is sometimes formed during the oxidative breakdown of hemoglobin. It then remains in the cell. Unlike hemoglobin, it is light green.
Verdoglobin appears in the urine of people with severe burns and turns it green if sepsis from Pseudomonas infection is present. Verdoglobin can be determined fluorimetrically . A sulfhemoglobinemia (the occurrence of sulfhemoglobin Verdoglobin or in the blood) can be used as, in rare cases undesirable effect by certain drugs can occur. The clinical symptoms are usually less severe than in methaemoglobinemia , although sulfhemoglobin is formed irreversibly and cannot take over the transport of oxygen.
Individual evidence
- ^ A b John P. Greer (Editor), Daniel A. Arber (Editor), George M. Rodgers (Editor), Frixos Paraskevas (Editor), John Foerster (Editor), Bertil E. Glader (Editor), Robert Means ( Editor): Wintrobe's Clinical Hematology . Lippincott Williams & Wilki; Edition: 12th edition December 2008; ISBN 978-0781765077 ; Pp. 147-148.
- ^ Peter Nuhn : Naturstoffchemie , Akademie Verlag Berlin, 1990, pp. 381-403, ISBN 3-7776-0473-9 .
- ↑ Manfred Kiese, Hedwig Kaeske: Connections of muscle hemoglobin . In: Biochemical Journal . 312, 1942, pp. 121-149.
- ↑ HH Stone: Review of pseudomonas sepsis in thermal burns: verdoglobin determination and gentamicin therapy. PMC 1251713 (free full text).
- ↑ Reports from the Medicines Commission of July 31, 2007. ADR: Sumatriptan and sulfhemoglobin formation . Pharmaceutical Newspaper, Issue 31, 2007.