Vishva Dixit

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Vishva Mitra Dixit (* 1956 in Kenya ) is an Indian-born Kenyan- American pathologist and molecular biologist with Genentech .

Dixit studied medicine at the University of Nairobi and completed his clinical training in pathology at Kenyatta National Hospital . After working in pathology at Washington University in St. Louis , he received a professorship in pathology at the University of Michigan in 1986 . In 1987 he became an American citizen. In 1997, Dixit joined the oncology division at biotechnology company Genentech as director . After ten years in this position, Dixit moved to the Biochemistry Department at Genentech as Vice Director and has since concentrated more on his own basic research . He also leads the postdoctoral program at Genentech.

Dixit deals with the molecular mechanisms of cell death and inflammation . He discovered several caspases and the fact that caspases are involved in death-receptor -mediated apoptosis , which ultimately enabled the process of the entire "death cascade" (see Caspasen # Caspase cascade ) to be elucidated. He also discovered the death receptor FADD and the gene families of the paracaspases and metacaspases (the latter play an important role in lymphomas ) and the phenomenon of ubiquitin editing as well as the ubiquitin editor TNFAIP3 (or A20) and the non-canonical inflammasome caspase-11.

In 2011 he was elected to the American Academy of Arts and Sciences , 2012 to the European Molecular Biology Organization , and 2013 to the National Academy of Sciences .

literature

  • An interview with Vishva M. Dixit . In: Trends in Pharmacological Sciences . tape 34 , no. November 11 , 2013, p. 596 , doi : 10.1016 / j.tips.2013.09.005 .

Web links

Individual evidence

  1. ↑ Vishva Mitra Dixit: USP1 inhibition: a differentiation strategy for Osteogenic Sarcoma . In: The FASEB Journal . tape 26 , Supplement 1, April 2012, p. 220.3 ( fasebj.org ).
  2. ↑ Book of Members 1780 – present, Chapter D. (PDF; 575 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved December 16, 2017 .
  3. ^ Vishva Dixit. In: people.embo.org. Retrieved December 16, 2017 .
  4. ^ Vishva Dixit. In: nasonline.org. Retrieved December 16, 2017 .
personal data
SURNAME Dixit, Vishva
ALTERNATIVE NAMES Dixit, Vishva M .; Dixit, Vishva Mitra
BRIEF DESCRIPTION Kenyan-American molecular biologist
DATE OF BIRTH 1956
PLACE OF BIRTH Kenya