Holoprosencephaly and Rainbow Room: Difference between pages
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{{dablink|For the Los Angeles nightclub, see [[Rainbow Bar and Grill]].}} |
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{{DiseaseDisorder infobox | |
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{{Infobox Restaurant |
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Name = Holoprosencephaly | |
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| name = The Rainbow Room |
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| image = rainbow room.jpg |
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| image_width = 300px |
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| image_caption = The Rainbow Room in December, 2004 |
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Image = EmbryonicBrain.svg| |
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| established = 1934 |
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Caption = Diagram depicting the main subdivisions of the embryonic vertebrate brain. | |
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| current-owner = |
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| head-chef = |
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| food-type = |
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| dress-code = |
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eMedicineSubj = radio | |
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| rating = |
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eMedicineTopic = 347 | |
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| street-address = 30 [[Rockefeller Plaza]], 65th Floor |
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DiseasesDB = 29610 | |
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| city = [[New York City]] |
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| state = [[New York]] |
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| zip = 10112 |
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| country = [[United States]] |
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| seating-capacity = |
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| reservations = |
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| other-locations = |
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| other-information= |
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| website = [http://www.rainbowroom.com www.rainbowroom.com] |
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}} |
}} |
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The '''Rainbow Room''' is an upscale [[restaurant]] and [[nightclub]] on the sixty-fifth floor of the [[GE Building]] in [[Rockefeller Center]], [[Midtown Manhattan]], [[New York City]]. |
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'''Holoprosencephaly''' is a type of [[cephalic disorder]]. This is a disorder characterized by the failure of the [[prosencephalon]] (the [[forebrain]] of the [[embryo]]) to develop. During normal development the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. (The condition also occurs in other species, as with Cy, the [[Cyclopia|Cyclops]] [[kitten]].) Holoprosencephaly is caused by a failure of the embryo's forebrain to divide to form bilateral [[cerebral hemispheres]] (the left and right halves of the [[brain]]), causing defects in the development of the [[face]] and in brain structure and function. |
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== |
==Cuisine== |
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Symptoms of holoprosencephaly range from mild (no facial/organ defects, anosmia, or only a single central [[incisor]]) to moderate ([[cleft lip]] or [[cleft palate]]) to severe (synophthalmia proboscis or [[cyclopia]]). |
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The food is loosely northern Italian, and there are [[cocktail]]s, [[wine]]s, [[liqueur]]s, [[cognac]]s, and other drinks available. |
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There are four classifications of holoprosencephaly. |
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* Alobar holoprosencephaly, the most serious form in which the brain fails to separate, is usually associated with severe facial anomalies. |
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==Environment== |
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* Semilobar holoprosencephaly, in which the brain's hemispheres have a slight tendency to separate, is an intermediate form of the disease. |
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* Lobar holoprosencephaly, in which there is considerable evidence of separate brain hemispheres, is the least severe form. In some cases of lobar holoprosencephaly, the patient's brain may be nearly normal. |
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* Middle Interhemispheric Variant of Holoprosencephaly (MIHV) -- where the middle of the brain (posterior frontal and parietal lobes) are not well separated. |
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The Rainbow Room features a revolving [[dance floor]], a live [[big band]] [[orchestra]], and what is generally considered an impressive view of the New York City [[skyline]]. |
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== Presentation == |
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Holoprosencephaly, once called '''arhinencephaly''', consists of a spectrum of defects or malformations of the brain and face. At the most severe end of this spectrum are cases involving serious malformations of the brain, malformations so severe that they often cause [[miscarriage]] or [[stillbirth]]. At the other end of the spectrum are individuals with facial defects - which may affect the [[eye]]s, [[nose]], and upper [[lip]] - and normal or near-normal brain development. [[Seizures]] and [[mental retardation]] may occur. |
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Private events are hosted in several banquet rooms, and, for special events and holidays. elaborate celebrations are organized. On [[New Year's Eve]], for example, the [[caviar]], [[truffles]], [[Champagne (wine)|champagne]], and mixed drinks are included with the price of admission, for dinner through to breakfast at sunrise. However, it is still expensive; for example, admission to the 2007 New Year's Eve party was $1600.00 per person. |
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The most severe of the facial defects (or [[anomalies]]) is [[cyclopia]], an abnormality characterized by the development of a single [[eye]], located in the area normally occupied by the root of the [[nose]], and a missing nose or a nose in the form of a [[proboscis]] (a tubular appendage) located above the eye. The condition is also referred to as cyclocephaly or synophthalmia and is very rare. |
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On the same floor of the GE building is The "[[Rainbow Grill]]", a separate, somewhat less expensive restaurant with an [[à la carte]] menu and that has its own celebrations for main holidays. |
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== Causes == |
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==History== |
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The cause of holoprosencephaly (HPE) is currently unknown. Often, no specific cause can be identified. Suggested risk factors include maternal [[diabetes]], [[infections]] during [[pregnancy]] ([[syphilis]], [[toxoplasmosis]], [[rubella]], [[herpes]], [[cytomegalovirus]]), and various drugs taken during pregnancy ([[alcohol]], [[aspirin]], [[lithium]], [[thorazine]], [[anticonvulsants]], [[hormones]], [[retinoic acid]]). Women with previous pregnancy loss and first [[trimester]] bleeding are also more likely to have a child diagnosed with holoprosencephaly. |
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The Rainbow Room first opened on October 3, 1934, and was originally conceived as a formal [[supper club]], where the elite and influential of New York could gather to socialize over [[cocktails]], dine on fine cuisine, and dance to the strains of legendary [[big bands]] on a revolving floor. |
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Although many children with holoprosencephaly have normal [[chromosomes]], specific chromosomal abnormalities have been identified in some patients. There is evidence that in some families, HPE is inherited ([[autosomal]] dominant as well as autosomal or X-linked recessive inheritance). Features consistent with familial transmission of the disease (e.g., a single central maxillary incisor) should be carefully assessed in parents and family members. |
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In 1974, [[David Rockefeller]], the son of [[John D. Rockefeller]], commissioned a $25 million restoration and expansion of the Rainbow Room led by [[Joe Baum]] and Arthur Emil. |
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Several [[genes]] have been identified that play a role in holoprosencephaly, specifically SHH, ZIC2, TGIF, and SIX3. |
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In 1998, the [[Rockefeller family]] passed operations of the facilities of the restaurant over to the [[Italy|Italian]] [[Cipriani]] family, founders of the renowned [[Harry's Bar]] in [[Venice]], as well as several other [[restaurants]] in New York City. |
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Source: The Carter Center for Research in holoprosencephaly http://www.stanford.edu/group/hpe/ and http://www.holoprosencephaly.net |
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In 2008, the [[Cipriani]] company filed a brief with the [[City of New York]], requesting that the Rainbow Room be designated a [[historic landmark]]. |
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[[Armand Marie Leroi]] <ref name="Mutants">[[Armand Marie Leroi]], ''[[Mutants]]: On the Form, Varieties and Errors of the Human Body'', 2003, Harper Perennial, London. ISBN 0-00-653164-4</ref> describes the cause of [[cyclopia]] as a genetic malfunctioning during the process by which the [[embryonic]] brain is divided into two. Only later does the [[visual cortex]] take recognizable form, and at this point an individual with a single [[forebrain]] region will be likely to have a single, possibly rather large, eye (at such a time, individuals with separate cerebral hemispheres would form two eyes). |
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==In the Media== |
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Increases in expression of such genes as Pax-2, as well as inhibition of Pax-6, from the [[notochord]] have been implicated in normal [[differentiation]] of cephalic midline structures. Inappropriate expression of any of these genes may result in mild to severe forms of holoprosencephaly. |
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In his memoir, ''[[Kitchen Confidential]]'', chef [[Anthony Bourdain]] wrote an entire chapter ("I Make My Bones") about his year and a half in the kitchen staff of the Rainbow Room, describing in detail - both good and bad - the working conditions in an extremely famous and busy restaurant and the numerous dealings normally kept invisible behind the kitchen doors. |
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== Prognosis == |
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Holoprosencephaly (HPE)is not a condition in which the brain deteriorates over time. Although serious seizure disorders, autonomic dysfunction, complicated [[endocrine]] disorders and other life-threatening conditions may sometimes be associated with HPE, the mere presence of HPE does not mean that these serious problems will occur or develop over time without any previous indication or warning. These abnormalities are usually recognized shortly after [[birth]] or early in life and only occur if areas of the brain controlling those functions are fused, malformed or absent. |
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Prognosis is dependent upon the degree of fusion and malformation of the brain, as well as other health complications that may be present. |
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The more severe forms of holoprosencephaly are usually fatal. This disorder consists of a spectrum of defects, malformations and associated abnormalities. [[Disability]] is based upon the degree in which the brain is affected. Moderate to severe defects may cause mental retardation, [[spastic]] quadriparesis, atheoid movements, endocrine disorders, [[epilepsy]] and other serious conditions. Whereas, mild brain defects may only cause learning or behavior problems with few motor impairments. |
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Seizures may develop over time with the highest risk before 2 yrs of age and the onset of [[puberty]]. Most are managed with one [[medication]] or a combination of medications. Typically, seizures that are difficult to control appear soon after birth, requiring more aggressive medication combinations/doses. |
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Most children with HPE are at risk of having elevated blood [[sodium]] levels during moderate-severe illnesses, that alter fluid intake/output, even if they have no previous diagnosis of diabetes insipidus or hypernatremia. |
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== References == |
== References == |
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* [http://www.rainbowroom.com Rainbowroom.com] |
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* [http://query.nytimes.com/gst/fullpage.html?res=9B0DE7D91E31F934A3575BC0A961948260&sec=&spon=&pagewanted=2 Article from [[The New York Times]]] |
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* [http://www.nytimes.com/2008/08/07/nyregion/07cipriani.html [[New York Times]] article about the Cipriani family and desire to designate Rainbow Room a Historic Landmark] |
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{{NYC-stub}} |
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<references/> |
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{{restaurant-stub}} |
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== External links == |
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* {{NINDS|holoprosencephaly}} |
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* http://www.holoprosencephaly.net |
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{{coord missing|United States}} |
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== See also == |
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* [[cephalic disorder]] |
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{{Congenital malformations and deformations of nervous system}} |
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[[Category: |
[[Category:Rockefeller Center]] |
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[[Category:Drinking establishments in Manhattan]] |
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[[Category:Restaurants in New York City]] |
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[[Category: Nightclubs in New York City]] |
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[[fr:Rainbow Room]] |
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[[de:Holoprosencephalie]] |
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[[es:Holoprosencefalia]] |
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[[fr:Holoproencéphalie]] |
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[[it:Oloprosencefalia]] |
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[[pl:Holoprozencefalia]] |
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[[pt:Holoprosencefalia]] |
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[[fi:Holoprosenkefalia]] |
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Revision as of 21:56, 12 October 2008
| The Rainbow Room | |
|---|---|
 The Rainbow Room in December, 2004 | |
 | |
| Restaurant information | |
| Established | 1934 |
| Street address | 30 Rockefeller Plaza, 65th Floor |
| City | New York City |
| State | New York |
| Postal/ZIP Code | 10112 |
| Country | United States |
| Website | www.rainbowroom.com |
The Rainbow Room is an upscale restaurant and nightclub on the sixty-fifth floor of the GE Building in Rockefeller Center, Midtown Manhattan, New York City.
Cuisine
The food is loosely northern Italian, and there are cocktails, wines, liqueurs, cognacs, and other drinks available.
Environment
The Rainbow Room features a revolving dance floor, a live big band orchestra, and what is generally considered an impressive view of the New York City skyline.
Private events are hosted in several banquet rooms, and, for special events and holidays. elaborate celebrations are organized. On New Year's Eve, for example, the caviar, truffles, champagne, and mixed drinks are included with the price of admission, for dinner through to breakfast at sunrise. However, it is still expensive; for example, admission to the 2007 New Year's Eve party was $1600.00 per person.
On the same floor of the GE building is The "Rainbow Grill", a separate, somewhat less expensive restaurant with an à la carte menu and that has its own celebrations for main holidays.
History
The Rainbow Room first opened on October 3, 1934, and was originally conceived as a formal supper club, where the elite and influential of New York could gather to socialize over cocktails, dine on fine cuisine, and dance to the strains of legendary big bands on a revolving floor.
In 1974, David Rockefeller, the son of John D. Rockefeller, commissioned a $25 million restoration and expansion of the Rainbow Room led by Joe Baum and Arthur Emil.
In 1998, the Rockefeller family passed operations of the facilities of the restaurant over to the Italian Cipriani family, founders of the renowned Harry's Bar in Venice, as well as several other restaurants in New York City.
In 2008, the Cipriani company filed a brief with the City of New York, requesting that the Rainbow Room be designated a historic landmark.
In the Media
In his memoir, Kitchen Confidential, chef Anthony Bourdain wrote an entire chapter ("I Make My Bones") about his year and a half in the kitchen staff of the Rainbow Room, describing in detail - both good and bad - the working conditions in an extremely famous and busy restaurant and the numerous dealings normally kept invisible behind the kitchen doors.
References
- Rainbowroom.com
- Article from The New York Times
- New York Times article about the Cipriani family and desire to designate Rainbow Room a Historic Landmark
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