Long-term effects of alcohol

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Total recorded alcohol per capita consumption (15+), in litres of pure alcohol[1]

Regularly having more than two drinks a day increases the risk of developing alcoholism, alcoholic liver disease, and some forms of cancer. Having between one to two alcoholic drinks a day has been shown to have positive effects on health, unless contradicated,[2] chiefly because of its cardiovascular effects.[3][4][5][6] A few researchers have questioned the extent of positive effects as most studies compare moderate drinkers' health to non-drinkers, but fail to take into account the number of people who abstain because they are already ill, rather than lack of alcohol causing their ill-health.[7]

Scientific studies

History

The relationship between alcohol consumption and health has been the subject of formal scientific research since at least 1926, when Dr. Raymond Pearl published his book, Alcohol and Longevity.[8] Since that time data have come in from all over the world. Studies have focused on both men and women, various age groups, and people of many ethnic groups. Published papers now total in the many hundreds, but many studies are not simply correlated, or time sequenced in nature. Some of the ways alcohol affects cardiovascular health are now understood.[9]

Modern understanding

Research in various countries has found the all-cause mortality rates range from 16 to 28% lower among moderate drinkers than among abstainers.[10][11][12][13]

Quantity recommended
Main article: Recommended maximum intake of alcoholic beverages

The U.S. National Institute on Alcohol Abuse and Alcoholism (NIAAA) has completed an extensive review of current scientific knowledge about the health effects of moderate alcohol consumption. It found that the lowest death rate from all causes occurs at the level of one to two drinks per day. That is, moderate drinkers have the greatest longevity.[14][15]

A 23-year prospective study of 12,000 male British physicians aged 48–78, found that overall mortality was significantly lower in the group consuming an average of 2–3 "units" (British unit = 8 g) per day than in the non-alcohol-drinking group (relative risk 0.81, confidence interval 0.76–0.87, P = 0.001).[16] The authors noted that the causes of death that are already known to be augmentable by alcohol accounted for only 5% of the deaths (1% liver disease, 2% cancer of the mouth, pharynx, larynx, or oesophagus, and 2% external causes of death) and were significantly elevated only among men consuming >2 units/day.

In a 1996 American Heart Association scientific statement, Thomas A. Pearson, MD, PhD noted:

A large number of observational studies have consistently demonstrated a U-shaped relation between alcohol consumption and total mortality. This relation appears to hold in men and women who are middle aged or older. The lowest mortality occurs in those who consume one or two drinks per day. In teetotalers or occasional drinkers, the rates are higher than in those consuming one or two drinks per day. In persons who consume three or more drinks per day, total mortality climbs rapidly with increasing numbers of drinks per day.

Cardiovascular system

The cardiovascular effects of consistent, moderate alcohol intake are perhaps the most studied and the most widely-accepted. The World Health Organization Technical Committee on Cardiovascular Disease asserted that the relationship between moderate alcohol consumption and reduced death from heart disease could no longer be doubted.[17] Consumption of red wine may be particularly favourable, since red wines contain certain polyphenol antioxidants associated with cardiovascular health. One study determined that the potential long-term benefits of moderate alcohol consumption on cardiovascular health surpassed all other factors except the cessation of smoking.[18]

Alcohol appears to be hormetic.[19] Medical research demonstrates that, consumed in moderation, alcohol increases HDL (“good cholesterol”), decreases thrombosis (blood clotting), reduces fibrinogen (a blood clotter), increases fibrinolysis (clot dissolving), reduces artery spasm from stress, increases coronary blood flow and increases insulin sensitivity -- all good for heart health.[20][21] Additionally, Thrombosis is lower among moderate drinkers than teetotalers.[22]

Cardiovascular disease

Main article: Alcohol and cardiovascular disease

Moderate drinkers are less likely to suffer heart attacks than total abstainers or heavy drinkers. The first scientific study of the relationship between alcohol consumption and atherosclerosis was published in the Journal of the American Medical Association in 1904. A review of major heart disease studies has found that:

"Alcohol consumption is related to total mortality in a U-shaped manner, where moderate consumers have a reduced total mortality compared with total non-consumers and heavy consumers"

The risk of a heart attack among moderate drinkers with diabetes is 52 percent lower than among nondrinkers and that the risk of dying in the four years after a heart attack is 32 percent lower among those who were moderate drinkers in the year before the attack.

Coronary Heart Disease

Pearson reviewed the evidence supporting the effect of alcohol consumption on coronary heart disease (CHD): "More than a dozen prospective studies have demonstrated a consistent, strong, dose-response relation between increasing alcohol consumption and decreasing incidence of CHD. The data are similar in men and women in a number of different geographic and ethnic groups. Consumption of one or two drinks per day is associated with a reduction in risk of approximately 30% to 50%. Studies of coronary narrowings defined by cardiac catheterization or autopsy show a reduction in atherosclerosis in persons who consume moderate amounts of alcohol. In general, the inverse association is independent of potential confounders, such as diet and cigarette smoking. Concerns that the association could be an artifact due to cessation of alcohol consumption in persons who already have CHD have largely been disproved."[23]

Another study found that when men increased their alcohol intake from very low to moderate, they significantly reduced their risk of coronary heart disease. The study monitored the health of 18,455 males for a period of seven years.[24]

Coronary Vascular Disease

Moderate drinking has been found to reduce the risk of angina pectoris.[25] In heart attack patients, treated with alcohol, the tissues affected by low blood flow are healthier and stronger, than those who receive no alcohol, because of alcohol's positive effects on artery walls.[26] Drinking alcoholic beverages in moderation may help patients recover from coronary stenting, as healing appears to be promoted by its anti-inflammitory effects.[27]

Peripheral Arterial Disease

"Moderate alcohol consumption appears to decrease the risk of PAD in apparently healthy men.".[28] "In this large population-based study, moderate alcohol consumption was inversely associated with peripheral arterial disease in women but not in men. Residual confounding by smoking may have influenced the results. Among nonsmokers an inverse association was found between alcohol consumption and peripheral arterial disease in both men and women."[29][30]

Intermittent claudication (IC)

A study concluded, "Our data are consistent with a protective effect of moderate alcohol consumption on IC risk, with lowest risk observed in men consuming 13 to 24 g/d (1 to 2 drinks/d) and in women consuming 7 to 12 g/d (0.5 to 1 drink/d)."[31]

Heart attack and stroke

Drinking in moderation has been found to help those who have suffered a heart attack survive it.[32][33] To determine if moderate drinkers have fewer heart attacks because they might lead more healthful lifestyles than do abstainers or heavy drinkers, Harvard scientists recently reported their study of only healthy men who led healthful lifestyles. For up to 16 years the doctors monitored the health of 8,867 men who did not smoke, were of normal weight, exercised at least 30-60 minutes per day, and ate a balanced healthful diet. Among these healthy men with healthy lifestyles, those who consumed anywhere from 1/2 to two alcoholic drinks of beer, wine or liquor per day had significantly decreased risk of heart attacks. Those who averaged slightly more (one to two drinks per day) had the lowest risk.[34]

Compared to abstaining, drinking in moderation is associated with a reduced risk of stroke, whereas abusing alcohol is associated with an increased risk of stroke.[35] A study of over 22,000 male physicians aged 40-84 years old over an average of 12 years, concluded, "Light-to-moderate alcohol consumption reduces the overall risk of stroke and the risk of ischemic stroke in men. The benefit is apparent with as little as one drink per week. Greater consumption, up to one drink per day, does not increase the observed benefit."[36]

--68.229.12.62 (talk) 21:46, 12 October 2008 (UTC)===Cardiomyopathy=== Large amount of alcohol can lead to alcoholic cardiomyopathy, commonly known as "holiday heart syndrome." Alcoholic cardiomyopathy presents in a manner clinically identical to idiopathic dilated cardiomyopathy, involving hypertrophy of the musculature of the heart that can lead to a form of cardiac arrythmia. These electrical anomales, represented on an EKG, often vary in nature, but range from nominal changes of the PR, QRS, or QT intervals to paroxsysmal episodes of ventricular tachycardia. The pathophysiology of alcoholic cardiomyopathy has not been firmly identified, but certain hypotheses cite an increased secretion of epinephrine and norepinephrine, increased sympathetic output, or a rise in the level of plasma free fatty acids as possible mechanisms.[37]

Hematologic diseases

Alcoholics may have anemia from several causes;[38] they may also develop thrombocytopenia from direct toxic effect on megakaryocytes, or from hypersplenism.

Nervous system

Strokes

A meta-analysis of 35 previous studies of the effect of alcohol consumption on stroke risk found that:

"Compared with abstainers, consumption of more than 60 g of alcohol per day (i.e., over four standard drinks -- heavy drinking) was associated with an increased relative risk of total stroke, 1.64 (95% confidence interval [CI], 1.39-1.93); ischemic stroke, 1.69 (95% CI, 1.34-2.15); and hemorrhagic stroke, 2.18 (95% CI, 1.48-3.20), while consumption of less than 12 g/d was associated with a reduced relative risk of total stroke, 0.83 (95%, CI, 0.75-0.91) and ischemic stroke, 0.80 (95% CI, 0.67-0.96), and consumption of 12 to 24 g/d was associated with a reduced relative risk of ischemic stroke, 0.72 (95%, CI, 0.57-0.91). The meta-regression analysis revealed a significant nonlinear relationship between alcohol consumption and total and ischemic stroke and a linear relationship between alcohol consumption and hemorrhagic stroke."[39]

These findings have been disputed. A 2003 Johns Hopkins study has linked moderate alcohol use to brain shrinkage and did not find any reduced risk of stroke among moderate drinkers.[40]

Brain development

Consuming large amounts of alcohol over a period of time can impair normal brain development in humans.[41][42] Deficits in retrieval of verbal and nonverbal information and in visuospatial functioning were evident in youths with histories of heavy drinking during early and middle adolescence.[43]

Heavy alcohol consumption inhibits new brain cell development.[44]

Nearly half of chronic alcoholics may have myopathy.[45] Proximal muscle groups are especially affected. Twenty-five percent of alcoholics may have peripheral neuropathy, including autonomic.[46]

Cognition and dementia

Research has found moderate drinking to be associated with lower risk of dementia, including Alzheimer’s disease. A study concluded, "Compared with abstention, consumption of 1 to 6 drinks weekly is associated with a lower risk of incident dementia among older adults."[47] Another study concluded, "These findings suggest that light-to-moderate alcohol consumption is associated with a reduced risk of dementia in individuals aged 55 years or older. The effect seems to be unchanged by the source of alcohol."[48] "In a representative elderly cohort over an average of 7 years, a pattern of mild-to-moderate drinking, compared to not drinking, was associated with lesser average decline in cognitive domains over the same period." [49] "Alcohol drinking in middle age showed a U shaped relation with risk of mild cognitive impairment in old age. Risk of dementia increased with increasing alcohol consumption only in those individuals carrying the apolipoprotein e4 allele."[50] "Alcohol abuse is associated with increased prevalence of cognitive dysfunction among older subjects; however, a daily alcohol consumption of less than 40 g for women and 80 g or less for men might be associated with a decreased probability of cognitive impairment. This possible protective effect of alcohol consumption should be further assessed by prospective studies."[51] "This study suggested that light to moderate alcohol drinking might protect against dementia and Alzheimer's disease among old people, although the possibility that such an association may be due to information bias cannot be totally ruled out."[52] "Our data suggest that in women, up to one drink per day does not impair cognitive function and may actually decrease the risk of cognitive decline."[53] "Moderate levels of alcohol intake are associated with somewhat better cognition, which may be expressed most strongly in functions related to verbal knowledge and phonemic fluency. However, our observational study cannot rule out confounding associations with unmeasured factors."[54] "The moderate drinkers reported less depression, had higher self-reported health, performed better on instrumental everyday tasks, had stronger memory self-efficacy, and used more strategies to improve memory performance. In addition, these women had higher performance on tests of executive function: attention, concentration, psychomotor skills, verbal-associative capacities, and oral fluency."[55]

"In patients with mild cognitive impairment, up to 1 drink/day of alcohol or wine may decrease the rate of progression to dementia."[56]

"…there is no medical rationale to advise people over 65 to quit drinking wine moderately, as this habit carries no specific risk and may even be of some benefit for their health. Advising all elderly people to drink wine regularly for prevention of dementia would be however premature at this stage."[57]

"Researchers found that people who were heavy drinkers [defined as more than two drinks per day] developed Alzheimer’s 4.8 years earlier than those who were not heavy drinkers."[58]

"Of people who reported drinking alcohol in the past year, those who consumed at least one drink in the past week, compared with those who did not, were significantly less likely to have poor cognitive function. … However, the relations were weakened when social position was added to the model. The authors concluded that for middle-aged subjects, increasing levels of alcohol consumption were associated with better function regarding some aspects of cognition. Nonetheless, it is not proposed that these findings be used to encourage increased alcohol consumption."[59]

Another study concluded:

"After adjustment for age, education, and smoking status, men with CVD [cardiovascular disease]/diabetes and low-to-moderate alcohol intake had a significantly lower risk for poor cognitive function (MMSE £ 25) than abstainers (odds ratios of 0.3 for less than one drink and 0.2 for one to two drinks per day). Alcohol intake was not associated with cognitive decline. … Alcohol may result in an acute beneficial effect on cognitive function among those with CVD/diabetes. However, selection bias and unmeasured confounding should be of concern when evaluating these results."[60]

A further study concluded, "We report a positive association between moderate alcohol intake among middle-aged men and subsequent cognitive performance in later life. However, it is possible that the health risks associated with drinking outweigh any potential benefits for many elderly persons.[61]

A French study concluded:

"Among men, neuropsychological test scores were not associated with alcohol consumption in either univariate or multivariate analysis; nor did

the proportion of high cognitive performers vary by alcohol consumption. In contrast, among women, significant positive associations between alcohol consumption and cognitive performance were observed for most tests in multivariate analysis. … These findings suggest that, among women, moderate alcohol consumption may have a beneficial effect on cognitive function.[62]

"Abstainers have poorer cognitive function than light drinkers and further investigation is needed to determine what factors contribute to this."[63] "A range of demographic and physical function measures were found to explain partially the finding of abstainers having lower cognitive test scores. The effects of independent variables were largest in the 60–64-year-old age group with a trend for physical variables such as lung function and grip strength to become more important in the older age groups. In the 20–24-year-olds, the majority of the effect remained unexplained. There is evidence that poorer cognitive test performance by abstainers reflects in part selection effects and poorer physical functioning, but does not appear to be due to mental or physical health conditions or personality."[64]

A review states, "There is some evidence to suggest that light-to-moderate alcohol consumption (up to three alcoholic drinks a day, or between one and seven drinks a week) may reduce the risk of cognitive impairment in the elderly compared with those who abstain. Drinking in moderation may contribute to some brain atrophy, but it may also reduce the number of silent infarcts in the brain, a known risk factor for cognitive impairment. In addition, light drinking may reduce blood clotting and blood serum lipid levels, as well as stimulate acetylcholine production in the brain."[65]

Essential tremor

Essential tremors can be temporarily and dramatically relieved in up to two-thirds of patients by drinking small amounts of alcohol, thus avoiding the serious side effects of the most effective and expensive medications or the dangers of surgery.[66]

Wernicke-Korsakoff syndrome

Wernicke-Korsakoff syndrome is a manifestation of thiamine deficiency, usually as a secondary effect of alcohol abuse.[67] The syndrome is a combined manifestation of two eponymous disorders, Korsakoff's Psychosis and Wernicke's encephalopathy, named after Drs. Sergei Korsakoff and Carl Wernicke. Wernicke's encephalopathy is the acute presentation of the syndrome and is characterised by a confusional state while Korsakoff's psychosis main symptoms are amnesia and executive dysfunction.[68]

Psychological effects

Studies have shown that alcohol dependence relates directly to cravings and irritability.[69] Another study has shown that alcohol use is a significant predisposing factor towards antisocial behavior in children.[70] Depression, anxiety and panic disorder are disorders commonly reported by alcohol dependent people. The mental health disorders are often induced by alcohol misuse via distortion of brain neurochemistry as the disorders typically improve or disappear with prolonged abstinence although temporarily worsening in early withdrawal and recovery.[71][72][73] Psychosis is secondary to several alcohol-related conditions including acute intoxication and withdrawal after significant exposure.[74] Prominent hallucinations and/or delusions are usually present when a patient is intoxicated or recently withdrawn from alcohol.[74] Chronic alcohol misuse can cause psychotic type symptoms to develop, more so than with other drugs of abuse. A study found that there is an 8 fold increased risk of psychotic disorders in alcohol misusing men and 3 fold increased risk in alcohol misusing women.[75] DSM-IV-TR criteria for a alcohol-related psychotic disorder are as follows:[74]

  • Hallucinations or delusions are present. Hallucinations are false sensations and are often visual. Delusions are false ideas. Paranoia and occasionally grandiosity may be the delusions engaged here.
  • Evidence from the history, physical examination, or laboratory findings indicates either that the hallucinations or delusions developed during or within a month of substance intoxication or withdrawal or that medication use is etiologically related to the disturbance.
  • The disturbance is not better accounted for by a psychotic disorder that is not substance-induced. Evidence that the symptoms are better accounted for by a psychotic disorder that is not substance-induced might include the following:
  • The symptoms precede the onset of the substance or medication use.
  • The symptoms persist for a substantial period of time after cessation of acute withdrawal or severe intoxication, or the symptoms are substantially in excess of what would be expected given the type or amount of the substance use or the duration of use.
  • Other evidence suggests the existence of an independent non–substance-induced psychotic disorder.
  • The disturbance does not occur exclusively during the course of a delirium.

Digestive system and weight gain

See also: Alcohol and weight
See also: Alcoholic liver disease, Alcoholic hepatitis, Fatty liver, and Cirrhosis

Except from pancreatitis and liver disease, there is uncertainty whether alcohol is detrimental or beneficial to the gastrointestinal system. Its impact on weight-gain is contentious: some studies find no effect,[76] others find decreased[77] or increased effect on weight gain.

Alcohol use increases the risk of chronic gastritis (stomach inflammation);[78][79] it is one cause of cirrhosis, hepatitis, and pancreatitis in both its chronic and acute forms.

Metabolic syndrome

A study concluded, "Mild to moderate alcohol consumption is associated with a lower prevalence of the metabolic syndrome, with a favorable influence on lipids, waist circumference, and fasting insulin. This association was strongest among whites and among beer and wine drinkers."[80] "Odds ratios for the metabolic syndrome and its components tended to increase with increasing alcohol consumption."[81]

Gallbladder disease

Consumption of alcohol is unrelated to gallbladder disease.[82] However one study suggested that drinkers who take Vitamin C (ascorbic acid) might reduce their risk. "After adjustment for potential confounding variables, use of ascorbic acid supplements among drinkers was associated with a decreased prevalence of gallbladder disease … and cholecystectomy …. Use of ascorbic acid supplements among non-drinkers was not significantly associated with either prevalence of gallbladder disease or cholecystectomy. Further study is necessary to confirm our findings and, specifically, to examine the combined effects of ascorbic acid and alcohol on cholesterol metabolism."[83]

Gallstones

Research has found that drinking reduces the risk of developing gallstones. Compared with alcohol abstainers, the relative risk of gallstone disease, controlling for age, sex, education, smoking, and body mass index, is 0.83 for occasional and regular moderate drinkers (< 25 ml of ethanol per day), 0.67 … for intermediate drinkers (25-50 ml per day), and 0.58 … for heavy drinkers. This inverse association was consistent across strata of age, sex, and body mass index."[84] Frequency of drinking also appears to be a factor. "An increase in frequency of alcohol consumption also was related to decreased risk. Combining the reports of quantity and frequency of alcohol intake, a consumption pattern that reflected frequent intake (5-7 days/week) of any given amount of alcohol was associated with a decreased risk, as compared with nondrinkers. In contrast, infrequent alcohol intake (1-2 days/week) showed no significant association with risk.”[85]

Other systems

Urinary system: Kidney stones

Research indicates that drinking alcohol is associated with a lower risk of developing kidney stones. One study concludes, "Beer consumption was inversely associated with risk of kidney stones; each bottle of beer consumed per day was estimated to reduce risk by 40% …. Since beer seemed to be protective against kidney stones, the physiologic effects of other substances besides ethanol, especially those of hops, should also be examined."[86] "…consumption of coffee, alcohol, and vitamin C supplements were negatively associated with stones."[87] "After mutually adjusting for the intake of other beverages, the risk of stone formation decreased by the following amount for each 240-ml (8-oz) serving consumed daily: caffeinated coffee, 10%; decaffeinated coffee, 10%; tea, 14%; beer, 21%; and wine, 39%."[88] "…stone formation decreased by the following amount for each 240-mL (8-oz) serving consumed daily: 10% for caffeinated coffee, 9% for decaffeinated coffee, 8% for tea, and 59% for wine." (CI data excised from last two quotes.).[89]

Endocrine system: Diabetes

Moderate drinkers may have a lower risk of diabetes than non-drinkers. "Alcohol intake increases insulin sensitivity and may partly explain both the J-shaped relationship between the prevalence of diabetes and the amount of alcohol consumption and the decreased mortality for myocardial infarction."[90] "Compared with abstainers men who drank 30.0-49.9 g of alcohol daily had a relative risk of diabetes of 0.61."[91] "Consumption of 30 g/d of alcohol (2 drinks per day) has beneficial effects on insulin and triglyceride concentrations and insulin sensitivity in nondiabetic postmenopausal women."[92] After adjustment for age, randomized treatment assignment, smoking, physical activity, and body mass index, the relative risk estimates of diabetes for those reporting alcohol use of rarely/never were 1.00 (referent), 1 to 3 drinks per month 1.03, 1 drink per week 0.89, 2 to 4 drinks per week 0.74, 5 to 6 drinks per week 0.67, and 1 or more drinks per day 0.57.[93] "The results of this study suggested that moderate alcohol consumption may reduce the risk of type 2 diabetes. On the other hand, binge drinking and high alcohol consumption may increase the risk of type 2 diabetes in women."[94]

Endocrine system: Rheumatoid arthritis

Alcohol consumption is associated with decreased risk of rheumatoid arthritis.[95][96][97][98][99] Two recent studies report that the more alcohol consumed, the lower the risk of developing rheumatoid arthritis. Among those who drank regularly, the one-quarter who drank the most were up to 50% less likely to develop the disease compared to the half who drank the least.[100]

The researchers noted that moderate alcohol consumption also reduces the risk of other inflammatory processes such as cardiovascualar disease. Some of the biological mechanisms by which ethanol reduces the risk of destructive arthritis and prevents the loss of bone mineral density (BMD), which is part of the disease process.[101]

Skeletal system

A study concluded, "Alcohol either protects from RA rheumatoid arthritis or, subjects with RA curtail their drinking after the manifestation of RA".[102] Another study found, "Postmenopausal women who averaged more than 14 alcoholic drinks per week had a reduced risk of rheumatoid arthritis… "[103]

Moderate alcohol consumption is associated with higher bone mineral density in postmenopausal women. "…alcohol consumption significantly decreased the likelihood [of osteoporosis]."[104] "Moderate alcohol intake was associated with higher BMD in postmenopausal elderly women."[105] "Social drinking is associated with higher bone mineral density in men and women [over 45]."[106]

Immune system, bacterial contamination, viral infections, and cancer

Bacterial infection

Drinking strong alcoholic beverages with a meal may offer some protection against bacterial contamination. The antibacterial activity of red and white wine against enteropathogens, (e.g. Shigella or Salmonella[107]) may protect against bacterial diarrhoea in a similar way to bismuth salicylate.[108]

There is a protective effect of alcohol consumption against active infection with H pylori[109] In contrast, alcohol intake (comparing those who drink > 30 gm of alcohol per day to nondrinkers) is not associated with higher risk of duodenal ulcer.[110]

Common cold

A study on the common cold found that "Greater numbers of alcoholic drinks (up to three or four per day) were associated with decreased risk for developing colds because drinking was associated with decreased illness following infection. However, the benefits of drinking occurred only among nonsmokers. … Although alcohol consumption did not influence risk of clinical illness for smokers, moderate alcohol consumption was associated with decreased risk for nonsmokers."[111]

Another study concluded, "Findings suggest that wine intake, especially red wine, may have a protective effect against common cold. Beer, spirits, and total alcohol intakes do not seem to affect the incidence of common cold."[112]

Cancer

Main article: Alcohol and cancer

The NIAAA states that "Although epidemiologic studies have found a clear association between alcohol consumption and development of certain types of cancer, study findings are often inconsistent and may vary by country and by type of cancer."[113] The U.S. Department of Health & Human Services’ National Toxicology Program listed alcohol as a known carcinogen in 2000 .[114]

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) reports that "Although there is no evidence that alcohol itself is a carcinogen, alcohol may act as a cocarcinogen by enhancing the carcinogenic effects of other chemicals. For example, studies indicate that alcohol enhances tobacco's ability to stimulate tumor formation in rats (Garro & Lieber). In humans, the risk for mouth, tracheal, and esophageal cancer is 35 times greater for people who both smoke and drink than for people who neither smoke nor drink (Blot et al.), implying a cocarcinogenic interaction between alcohol and tobacco-related carcinogens (Garro & Lieber)."[113] One study determined that "3.6% of all cancer cases worldwide are related to alcohol drinking, resulting in 3.5% of all cancer deaths."[115] The NiAAA suggests that "considerable evidence suggests a connection between heavy alcohol consumption and increased risk for cancer, with an estimated 2 to 4 percent of all cancer cases thought to be caused either directly or indirectly by alcohol."[113]

The WCRF panel report Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective finds the evidence "convincing" that alcoholic drinks increase the risk of the following cancers: mouth, pharynx and larynx, oesophagus, colorectum (men), breast (pre- and postmenopause).[116]

Alcohol's effect on the fetus

Main articles: Fetal alcohol syndrome and Fetal Alcohol Spectrum Disorder

Fetal alcohol syndrome or FAS is a disorder of permanent birth defects that occurs in the offspring of women who drink alcohol during pregnancy. Drinking heavily or during the early stages of prenatal development has been conclusively linked to FAS; the impact of light or moderate consumption is not yet fully understood. Alcohol crosses the placental barrier and can stunt fetal growth or weight, create distinctive facial stigmata, damaged neurons and brain structures, and cause other physical, mental, or behavioural problems.[117] Fetal alcohol exposure is the leading known cause of mental retardation in the Western world.[118]

See also

References

  1. ^ Global Status Report on Alcohol 2004
  2. ^ Yuan, Jian-Min; Ross, Ronald K; Gao, Yu-Tang; Henderson, Brian E; Yu, Mimi C Follow up study of moderate alcohol intake and mortality among middle aged men in Shanghai, China British Medical Journal, 1997, 314, 18-23.
  3. ^ Hennekens, C.H. Alcohol and risk of coronary events. In: Zakhari, S., and Wassef, M., eds. Alcohol and the Cardiovascular System NIAAA Research Monograph No. 31. NIH Pub. No. 96-4133. Washington, DC: U.S. Govt. Print. Off., 1996. pp. 15-24.
  4. ^ Kowalski, R. E. The New 8-Week Cholesterol Cure. NY: HarperCollins, 2002, page 91
  5. ^ National Institute on Alcohol Abuse and Alcoholism. Alcohol Alert, No. 45, October, 1999; Blackwelder, W. C., et al. Alcohol and mortality. The Honolulu Heart Study. American Journal of Medicine, 1980, 68(2), 164-169.
  6. ^ Rimm et al., Trevisan et al.
  7. ^ BBC News | Health | Alcohol benefits debunked
  8. ^ Pearl, Raymond. Alcohol and Longevity. NY: Knopf, 1926.
  9. ^ Vliegenthart, R. et al. Alcohol consumption and coronary classification in a general population. Archives of Internal Medicine, 2004 (November), 164, 2355-2360; Koppes, L. et al. Blood cholesterol levels of 32-year-old consumers better than that of nonconsumers. Pharmacology, Biochemistry and Behavior, 2000, 66(1), 163-167; Albert, M.A. et al. Alcohol consumption and plasma concentrations iof C-reactive protien. Circulation, 2003, 107, 433-447; Baer, D.J. et al. Moderate alcohol consumption lowers rik factors for cardiovascular disease in postmenopausal women fed a controlled diet. American Journal of Clinical Nursing, 2002, 75, 593-599; Catena, C. et al. Serum lipoprotein(a) concentrations and alcohol consumption in hypertension. Journal of Hypertension, 2003, 21(2), 281-288
  10. ^ Boffetta, P., and Garfinkel, L. Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study Epidemiology 1990 Sep;1(5):342-8
  11. ^ Coate, D Moderate drinking and coronary heart disease mortality: evidence from NHANES I and the NHANES I Follow-up American Journal of Public Health Vol 83, Issue 6 888-890
  12. ^ Fuchs CS, Stampfer MJ, Colditz GA, Giovannucci EL, Manson JE, Kawachi I, Hunter DJ, Hankinson SE, Hennekens CH, Rosner B Alcohol consumption and mortality among women New England Journal of Medicine 1995 May 11;332(19):1245-50
  13. ^ Klatsky AL, Friedman GD, Siegelaub AB Alcohol and mortality. A ten-year Kaiser-Permanente experience Annals of Internal Medicine 1981 Aug;95(2):139-45
  14. ^ U.S. Government: Moderate Drinking Benefits Health (site funded by the Distilled Spirits Council of the United States)
  15. ^ Ellison, R. C. Does Moderate Alcohol Consumption Prolong Life? American Council on Science and Health, New York: 1993. (link is to review of book)
  16. ^ Doll et al Mortality in relation to alcohol consumption: a prospective study among male British doctors International Journal of Epidemiology 2005;34:199-204
  17. ^ Wilkie, S. Global overview of drinking recommendations and guidelines. AIM Digest, Supplement, June 1997, 2-4, p. 4
  18. ^ Ellison, R. Curtis Here's to your health. Wine Spectator, October 31, 1998, 34-46.
  19. ^ Roberts, Russell (2003-01-09). "Here's to Your Health". St. Louis Post Dispatch. Retrieved 2007-02-02.
  20. ^ Mennen LI, Balkau B, Vol S, Caces E, Eschwege E. Fibrinogen may explain in part the protective effect of moderate drinking on the risk of cardiovascular disease. Arteriosclerotic and Thrombodic Vascular Biology 1999 Apr;19(4):887-92
  21. ^ Paassilta Marita; Kervinen, Kari; Rantala, Asko O; Savolainen, Markku J; Lilja, Mauno; Reunanen, Antti; Kesäniemi, Y Antero Social alcohol consumption and low Lp(a) lipoprotein concentrations in middle aged Finnish men: population based study British Medical Journal 1998 February 14; 316(7131): 594–595
  22. ^ Lacoste, L. et al. Acute and delayed antithrombotic effects of alcohol in humans. American Journal of Cardiology, 2001, 87, 82-85; Pahor, M., et al. Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons. Journal of the American Geriatric Society, 1996, 44(9), 1030-1037; Ridker, P., et al. Moderate alcohol intake may reduce risk of thrombosis. American Medical Association press release, September 22, 1994; Ridker, P. The Pathogenesis of Atherosclerosis and Acute Thrombosis . In: Manson, J., et al. (Eds.) Prevention of Myocardial Infarction. NY: Oxford University Press, 1996.
  23. ^ Pearson, Thomas A. "Alcohol and Heart Disease." "Circulation 1996;94:3023-3025". Retrieved 2006-01-30.
  24. ^ Sesso, H.D., et al., Seven-year changes in alcohol consumption and subsequent risk of cardiovascular disease in men. Archives of Internal Medicine, 2001, 160, 2505-2612
  25. ^ Camargo CA Jr, Stampfer MJ, Glynn RJ, Grodstein F, Gaziano JM, Manson JE, Buring JE, Hennekens CH Moderate alcohol consumption and risk for angina pectoris or myocardial infarction in U.S. male physicians Archives of Internal Medicine 1997 Mar 1;126(5):372-5
  26. ^ Alcohol Helps Reduce Damage After Heart Attack
  27. ^ Zairis, M.N., et al. C Reactive protein, moderate alcohol consumption, and long term prognosis after successful coronary stenting: four year results from the GENERATION study. Heart, 2004, 90, 419-424
  28. ^ Camargo Carlos A; Stampfer, Meir J; Glynn, Robert J; Gaziano, J. Michael; Manson, JoAnn E; Goldhaber, Samuel; Hennekens, Charles H Prospective Study of Moderate Alcohol Consumption and Risk of Peripheral Arterial Disease in US Male Physicians Circulation 1997;95:577-580
  29. ^ Vliegenthart, Rozemarijn; Geleijnse, Johanna M; Hofman, Albert; Meijer, Wouter T; van Rooij, Frank J. A; Grobbee, Diederick E; Witteman, Jacqueline C. M. Alcohol Consumption and Risk of Peripheral Arterial Disease: The Rotterdam Study American Journal of Epidemiology Vol. 155, No. 4 : 332-338
  30. ^ Mingardi, R; Avogaro, A; Noventa, F; Strazzabosco, M; Stocchiero, C; Tiengo, A; Anderle, G "Alcohol intake is associated with a lower prevalence of peripheral vascular disease in non-insulin dependent diabetic women" Nutrition Metabolism and Cardiovascular Disease 7(4): 301– 308, 1997. (No abstract found online.)
  31. ^ Luc Djoussé; Daniel Levy; Joanne M. Murabito; L. Adrienne Cupples; R. Curtis Ellison Alcohol Consumption and Risk of Intermittent Claudication in the Framingham Heart Study Circulation. 2000;102:3092
  32. ^ Gaziano, J. et al. Potential mortality benefits for drinkers with previous heart attacks. The Lancet, 1998, 332, 1882-1885; Mulkamal, K.J. et al. Prior alcohol consumption and mortality following acute myocardial infarction. Journal of the American Medical Association, 2001, 285(15), 1965-1970
  33. ^ Alcohol helps reduce damage after heart attacks
  34. ^ Mulkamal, K.J., et al. Alcohol consumption and risk of coronary heart disease in men with healthy lifestyles. Archives of Internal Medicine, 2006 (October), 166(19), 2145-2150
  35. ^ Rodgers, H. et al. Alcohol and stroke. A case-control study of drinking habits past and present Stroke, 1993. 24(10), 1473-1477.
  36. ^ Berger et al Light-to-Moderate Alcohol Consumption and the Risk of Stroke among U.S. Male Physicians New England Journal of Medicine 341(21):1557-1564, November 18, 1999
  37. ^ eMedicine - Holiday Heart Syndrome : Article by Adam S Budzikowski
  38. ^ Savage D, Lindenbaum J (1986). "Anemia in alcoholics". Medicine (Baltimore). 65 (5): 322–38. PMID 3747828.
  39. ^ Reynolds et al Alcohol Consumption and Risk of Stroke JAMA 2003;289:579-588
  40. ^ Moderate Alcohol Consumption Linked To Brain Shrinkage
  41. ^ White AM, Bae JG, Truesdale MC, Ahmad S, Wilson WA, Swartzwelder HS Chronic-intermittent ethanol exposure during adolescence prevents normal developmental changes in sensitivity to ethanol-induced motor impairments Alcoholism: Clinical and Experimental Research 2002 Jul;26(7):960-8
  42. ^ Tapert SF, Brown GG, Kindermann SS, Cheung EH, Frank LR, Brown SA fMRI measurement of brain dysfunction in alcohol-dependent young women Alcoholism: Clinical & Experimental Research 2001 Feb;25(2):236-45
  43. ^ Brown SA, Tapert SF, Granholm E, Delis DC Neurocognitive functioning of adolescents: effects of protracted alcohol use Alcoholism: Clinical and Experimental Research 2000 Feb;24(2):164-71
  44. ^ American Association for the Advancement of Science New brain cells develop during alcohol abstinence, UNC study shows
  45. ^ Urbano-Marquez A, Estruch R, Navarro-Lopez F, Grau JM, Mont L, Rubin E (1989). "The effects of alcoholism on skeletal and cardiac muscle". N. Engl. J. Med. 320 (7): 409–15. PMID 2913506.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  46. ^ Monforte R, Estruch R, Valls-Solé J, Nicolás J, Villalta J, Urbano-Marquez A (1995). "Autonomic and peripheral neuropathies in patients with chronic alcoholism. A dose-related toxic effect of alcohol". Arch. Neurol. 52 (1): 45–51. PMID 7826275.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  47. ^ Mukamal, Kenneth J.; Kuller, Lewis H.; Fitzpatrick, Annette L.; Longstreth, W. T.; Mittleman, Murray A.; Siscovick, David S. Prospective Study of Alcohol Consumption and Risk of Dementia in Older Adults Journal of the American Medical Association, 2003 (March 19), 289, 1405-1413.
  48. ^ Annemieke Ruitenberg, John C van Swieten, Jacqueline CM Witteman, Kala M Mehta, Cornelia M van Duijn, Albert Hofman and Monique MB Breteler Alcohol consumption and risk of dementia: the Rotterdam Study The Lancet 2002; 359:281-286 DOI:10.1016/S0140-6736(02)07493-7
  49. ^ M. Ganguli, J. Vander Bilt, J. A. Saxton, C. Shen, and H. H. Dodge Alcohol consumption and cognitive function in late life: A longitudinal community study Neurology 2005;65:1210-1217
  50. ^ Tiia Anttila, Eeva-Liisa Helkala, Matti Viitanen, Ingemar Kåreholt, Laura Fratiglioni, Bengt Winblad, Hilkka Soininen, Jaakko Tuomilehto, Aulikki Nissinen, Miia Kivipelto Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study British Medical Journal 2004;329:539 (4 September), doi:10.1136/bmj.38181.418958.BE
  51. ^ Giuseppe Zuccalà, Graziano Onder, Claudio Pedone, Matteo Cesari, Francesco Landi, Roberto Bernabei, Alberto Cocchi (2001) Dose-Related Impact of Alcohol Consumption on Cognitive Function in Advanced Age: Results of a Multicenter Survey Alcoholism: Clinical and Experimental Research 25 (12) , 1743–1748 doi:10.1111/j.1530-0277.2001.tb02185.x
  52. ^ Wenyong Huanga, Chengxuan Qiua, Bengt Winblada and Laura Fratiglioni Alcohol consumption and incidence of dementia in a community sample aged 75 years and older Journal of Clinical Epidemiology Volume 55, Issue 10, October 2002, Pages 959-964
  53. ^ Stampfer MJ, Kang JH, Chen J, Cherry R, Grodstein F. Effects of moderate alcohol consumption on cognitive function in women New England Journal of Medicine 2005 Jan 20;352(3):245-53.
  54. ^ Espeland MA, Coker LH, Wallace R, Rapp SR, Resnick SM, Limacher M, Powell LH, Messina CR; Women's Health Initiative Study of Cognitive Aging Association between alcohol intake and domain-specific cognitive function in older women Neuroepidemiology 2006;27(1):1-12. Epub 2006 May 24
  55. ^ Teena Zimmerman, Graham J. McDougall Jr, Heather Becker Older women's cognitive and affective response to moderate drinking International Journal of Geriatric Psychiatry Volume 19, Issue 11 , Pages 1095 - 1102 10.1002/gps.1216
  56. ^ V. Solfrizzi, A. D’Introno, A. M. Colacicco, C. Capurso, A. Del Parigi, G. Baldassarre, P. Scapicchio, E. Scafato, M. Amodio, A. Capurso, F. Panza Alcohol consumption, mild cognitive impairment, and progression to dementia Neurology 2007;68:1790-1799
  57. ^ Orgogozo JM, Dartigues JF, Lafont S, Letenneur L, Commenges D, Salamon R, Renaud S, Breteler MB. Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area Revue neurologique (Paris) 1997 Apr;153(3):185-92
  58. ^ Alzheimer’s Starts Earlier for Heavy Drinkers, Smokers
  59. ^ Britton, Annie; Singh-Manoux, Archana; Marmot, Michael Alcohol Consumption and Cognitive Function in the Whitehall II Study American Journal of Epidemiology 2004 160(3):240-247; doi:10.1093/aje/kwh206
  60. ^ Launer, LJ; Feskens, EJM; Kalmijn, S; and Kromhout D Smoking, Drinking, and Thinking: The Zutphen Elderly Study American Journal of Epidemiology 1996 Feb 1;143(3):219-27
  61. ^ Galanis, Daniel J.; Joseph, Carol; Masaki, Kamal H.; Petrovitch, Helen; Ross, G. Webster; and White, Lon A Longitudinal Study of Drinking and Cognitive Performance in Elderly Japanese American Men: The Honolulu–Asia Aging Study American Journal of Public Health Vol 90, Issue 8 1254-1259
  62. ^ Dufouil, Carole; Ducimetière, Pierre; Alperovitch, Annick Sex Differences in the Association between Alcohol Consumption and Cognitive Performance American Journal of Epidemiology Vol. 146, No. 5: 405-412
  63. ^ Rodgers, Bryan; Windsor, Timothy D.; Anstey, Kaarin J.; Dear, Keith B. G.; F. Jorm, Anthony; Christensen, Helen Non-linear relationships between cognitive function and alcohol consumption in young, middle-aged and older adults: the PATH Through Life Project Addiction 2005, 100(9), 1280-1290
  64. ^ Anstey, Kaarin J.; Windsor, Timothy D.; Rodgers, Bryan; Jorm, Anthony F.; Christensen, Helen Lower cognitive test scores observed in alcohol are associated with demographic, personality, and biological factors: The PATH Through Life Project Addiction Volume 100, Number 9, September 2005 , pp. 1291-1301(11) DOI: 10.1111/j.1360-0443.2005.01159.x
  65. ^ Ross Andel, Tiffany F Hughes‌ & Michael Crowe Strategies to reduce the risk of cognitive decline and dementia Aging Health Aug 2005, Vol. 1, No. 1, Pages 107-116 (doi:10.2217/1745509X.1.1.107)
  66. ^ Charles P. D., et al. Classification of tremor and update on treatment. American Family Physician, 1999, 59(6), 565-72; Bain, P. G., et al. A study of hereditary essential tremor. Brain, 1994, 117 (Pt 4), 805-24 ; Lou, J.S., & Jankovic J. Essential tremor: clinical correlates in 350 patients. Neurology, 1991, 41 (2 Pt 1), 234-8; Singer C, et al. Gait abnormality in essential tremor. Movement Disorders, 1994, 9(2), 193-6; Wasielewski PG, et al. Pharmacologic treatment of tremor. Movement Disorders, 1998, 13 (Suppl 3), 90-100; Boecker, H., et al. The effect of ethanol on alcoholic-responsive essential tremors: a positron emission tomography study. Annals of Neurology, 1996, 39, 650-658, 1996; Setting a steady course for benign essential tremor. The Johns Hopkins Medical Letter, 1999 (December), 11(10).
  67. ^ Martin PR, Singleton CK, Hiller-Sturmhöfel S (2003). "The role of thiamine deficiency in alcoholic brain disease". Alcohol Res Health. 27 (2): 134–42. PMID 15303623.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  68. ^ Butters N (1981). "The Wernicke-Korsakoff syndrome: a review of psychological, neuropathological and etiological factors". Curr Alcohol. 8: 205–32. PMID 6806017.
  69. ^ Jasova D, Bob P, Fedor-Freybergh P (2007). "Alcohol craving, limbic irritability, and stress". Med. Sci. Monit. 13 (12): CR543–7. PMID 18049433. Retrieved 2008-05-13. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  70. ^ Young R, Sweeting H, West P (2008). "A longitudinal study of alcohol use and antisocial behaviour in young people". Alcohol Alcohol. 43 (2): 204–14. doi:10.1093/alcalc/agm147. PMID 17977868. Retrieved 2008-05-13.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  71. ^ Wetterling T (2000). "Psychopathology of alcoholics during withdrawal and early abstinence". Eur Psychiatry. 15 (8): 483–8. PMID 11175926. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  72. ^ Cowley DS (24). "Alcohol abuse, substance abuse, and panic disorder". Am J Med. 92 (1A): 41S–48S. PMID 1346485. {{cite journal}}: Check date values in: |date= and |year= / |date= mismatch (help); Unknown parameter |month= ignored (help)
  73. ^ Cosci F (2007). "Alcohol use disorders and panic disorder: a review of the evidence of a direct relationship". J Clin Psychiatry. 68 (6): 874–80. PMID 17592911. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  74. ^ a b c Larson, Michael (2006-03-30). "Alcohol-Related Psychosis". eMedicine. Retrieved 2008-05-13. {{cite web}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  75. ^ Tien AY (1990). "Epidemiological analysis of alcohol and drug use as risk factors for psychotic experiences". J Nerv Ment Dis. 178 (8): 473–80. PMID 2380692. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  76. ^ Cordain, L;, Bryan, E D; Melby, C L; Smith, M J Influence of moderate daily wine consumption on body weight regulation and metabolism in healthy free-living males Journal of the American College of Nutrition 1997, Vol 16, Issue 2 134-139.
  77. ^ (Arif, A. A. & Rohrer, J. E. Patterns of Alcohol Drinking and its Association with Obesity: Data from the Third National Health and Nutrition Examination Survey, 1988-1994 BMC Public Health, 2005 5 December), (5), 126.)
  78. ^ National Institute on Alcohol Abuse and Alcoholism (NIAAA) Alcohol Research & Health Vol. 24, No. 1, 2000 Health Risks and Benefits of Alcohol Consumption (PDF)
  79. ^ Bode, Christiane; Bode, J. Christiane Alcohol’s Role in Gastrointestinal Tract Disorders Alcohol Health & Research World Vol. 21, No. 1, 1997
  80. ^ Matthew S. Freiberg, Howard J. Cabral, Tim C. Heeren, Ramachandran S. Vasan, and R. Curtis Ellison Alcohol Consumption and the Prevalence of the Metabolic Syndrome in the U.S.: A cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey Diabetes Care 27:2954-2959, 2004
  81. ^ Yeong Sook Yoon, Sang Woo Oh, Hyun Wook Baik, Hye Soon Park and Wha Young Kim Alcohol consumption and the metabolic syndrome in Korean adults: the 1998 Korean National Health and Nutrition Examination Survey American Journal of Clinical Nutrition Vol. 80, No. 1, 217-224, July 2004
  82. ^ Sahi T, Paffenbarger RS Jr, Hsieh CC, Lee IM Body mass index, cigarette smoking, and other characteristics as predictors of self-reported, physician-diagnosed gallbladder disease in male college alumni American Journal of Epidemiology 1998 Apr 1;147(7):644-51
  83. ^ Simon JA, Grady D, Snabes MC, Fong J, Hunninghake DB Ascorbic acid supplement use and the prevalence of gallbladder disease. Heart & Estrogen-Progestin Replacement Study (HERS) Research Group Journal of Clinical Epidemiology 1998 Mar;51(3):257-65
  84. ^ La Vecchia C, Decarli A, Ferraroni M, Negri E Alcohol drinking and prevalence of self-reported gallstone disease in the 1983 Italian National Health Survey Epidemiology 1994 Sep;5(5):533-6
  85. ^ Leitzmann MF, Giovannucci EL, Stampfer MJ, Spiegelman D, Colditz GA, Willett WC, Rimm EB Prospective study of alcohol consumption patterns in relation to symptomatic gallstone disease in men Alcohol: Clinical and Experimental Research 1999 May;23(5):835-41
  86. ^ Hirvonen, Tero; Pietinen, Pirjo; Virtanen, Mikko; Albanes, Demetrius; Virtamo, Jarmo Nutrient Intake and Use of Beverages and the Risk of Kidney Stones among Male Smokers American Journal of Epidemiology Vol. 150, No. 2: 187-194
  87. ^ Soucie, J. Michael; Coates, Ralph J; McClellan, William; Austin, Harland; Michael Thun Relation between Geographic Variability in Kidney Stones Prevalence and Risk Factors for Stones American Journal of Epidemiology Vol. 143, No. 5: 487-495
  88. ^ Curhan GC, Willett WC, Rimm EB, Spiegelman D, Stampfer MJ Prospective study of beverage use and the risk of kidney stones American Journal of Epidemiology 1996 Feb 1;143(3):240-7
  89. ^ Curhan GC, Willett WC, Speizer FE, Stampfer MJ Beverage use and risk for kidney stones in women Annals of Internal Medicine 1998 Apr 1;128(7):534-40
  90. ^ Avogaro A, Watanabe RM, Dall'Arche A, De Kreutzenberg SV, Tiengo A, Pacini G. Acute alcohol consumption improves insulin action without affecting insulin secretion in type 2 diabetic subjects Diabetes Care, 2004 (June 6), 27(6), 1369-1374
  91. ^ Rimm EB, Chan J, Stampfer MJ, Colditz GA, Willett WC Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men British Medical Journal 1995 Mar 4;310(6979):555-9
  92. ^ Davies, Michael J; Baer, David J; Judd, Joseph T; Brown, Ellen D; Campbell, William S; Taylor, Philip R Effects of Moderate Alcohol Intake on Fasting Insulin and Glucose Concentrations and Insulin Sensitivity in Postmenopausal Women: A Randomized Controlled Trial Journal of the American Medical Association, 2002, 287(19), 2559-2562.
  93. ^ Ajani, Umed A; Hennekens, Charles H; Spelsberg, Angela; Manson, JoAnn E Alcohol Consumption and Risk of Type 2 Diabetes Mellitus Among US Male Physicians Archives of Internal Medicine, 2000, 160, 1025-1050
  94. ^ Sofia Carlsson, Niklas Hammar, Valdemar Grill, and Jaakko Kaprio Alcohol consumption and the incidence of type 2 diabetes: a 20-year follow-up of the Finnish Twin Cohort Study Diabetes Care, 2003, 26(10), 2785-2786.
  95. ^ http://arc.org.uk/arthinfo/patpubs/6033/6033.asp
  96. ^ Myllykangas-Lusojarvi, R. Reduced Incidence of Alcohol related Deaths in subjects with Rheumatoid Arthritis, Ann. Rheum. Dis,, 2000, 75-76
  97. ^ C. Nagata. Systemic Lupus-Erythematosis, Int. J. Derm, 1995, 34(5), 333-7
  98. ^ Aho, K, & Heloivaara, M. Alcohol, Androgens and Arthritis, Ann. Rheum. Dis. 1993, 52, 897
  99. ^ Smoking history, alcohol consumption, and systemic lupus erythematosus: a case-control study - Hardy et al. 57 (8): 451 - Annals of the Rheumatic Diseases
  100. ^ H. Kaalberg, Alcohol Consumption is Associated with decreased Risk of Rheumatoid Arthritis: Results from Two Scandinavian Cas-Control Sttudies, Ann. Rheum. Dis, Pub. Online First: 5 June 2008. doi:10.1136/ard.2007.086314
  101. ^ I-M Jonsson. Ethanol Prevents Development of Destructive Arthritis, Proceedings of the National Academy of Sciences, January 2, 2007, 104 (1), 258-263
  102. ^ Myllykangas-Lusojarvi, R., Aho, K., Kautiainen, H., and Hakala, M. Reduced incidence of alcohol related deaths in subjects with rheumatoid arthritis Annals of Rheumatoid Diseases, 2000, 59, 75-76;
  103. ^ Voight, L., et al. Smoking, obesity, alcohol consumption and the risk of rheumatoid arthritis Epidemiology, 1994, 5, 525-532.
  104. ^ Siris, Ethel S; Miller, Paul D; Barrett-Connor, Elizabeth; Faulkner, Kenneth G; Wehren, Lois E; Abbott, Thomas A; Berger, Marc L; Santora, Arthur C; Sherwood, Louis M Identification and Fracture Outcomes of Undiagnosed Low Bone Mineral Density in Postmenopausal Women Journal of the American Medical Association, 2001;286:2815-2822
  105. ^ Rapuri, Prema B; Gallagher, J Christopher; Balhorn, Kurt E; Ryschon, Kay L Alcohol intake and bone metabolism in elderly women American Journal of Clinical Nursing Vol. 72, No. 5, 1206-1213, November 2000
  106. ^ Holbrook TL, Barrett-Connor E A prospective study of alcohol consumption and bone mineral density British Medical Journal 1993 Jun 5;306(6891):1506-9
  107. ^ Desenclos JA, Klontz KC, Wilder MH, Gunn RA The protective effect of alcohol on the occurrence of epidemic oyster-borne hepatitis A Epidemiology 1992 Jul;3(4):371-4
  108. ^ Weisse, Martin E; Eberly, Bardwell; Person, Donald A Wine as a digestive aid: comparative antimicrobial effects of bismuth salicylate and red and white wine British Medical Journal 1995;311:1657-1660 (23 December)
  109. ^ Brenner, Hermann; Rothenbacher, Dietrich; Bode, Günter; Adler, Guido Relation of smoking and alcohol and coffee consumption to active Helicobacter pylori infection: cross sectional study British Medical Journal 1997;315:1489-1492 (6 December)
  110. ^ Aldoori WH, Giovannucci EL, Stampfer MJ, Rimm EB, Wing AL, Willett WC A prospective study of alcohol, smoking, caffeine, and the risk of duodenal ulcer in men Epidemiology 1997 Jul;8(4):420-4.
  111. ^ S Cohen, D A Tyrrell, M A Russell, M J Jarvis and A P Smith Smoking, alcohol consumption, and susceptibility to the common cold American Journal of Public Health Vol. 83, Issue 9 1277-1283
  112. ^ Bahi Takkouche, Carlos Regueira-Méndez, Reina García-Closas, Adolfo Figueiras, Juan J. Gestal-Otero and Miguel A. Hernán Intake of Wine, Beer, and Spirits and the Risk of Clinical Common Cold American Journal of Epidemiology Vol. 155, No. 9 : 853-858
  113. ^ a b c National Institute on Alcohol Abuse and Alcoholism Alcohol Alert No. 21 PH 345 July 1993
  114. ^ National Toxicology Program Alcoholic Beverage Consumption: Known to be a human carcinogen First listed in the Ninth Report on Carcinogens (2000)(PDF)
  115. ^ Burden of alcohol-related cancer substantial
  116. ^ WCRF Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective
  117. ^ Ulleland CN (1972). "The offspring of alcoholic mothers". Ann. N. Y. Acad. Sci. 197: 167–9. PMID 4504588. {{cite journal}}: |access-date= requires |url= (help); Unknown parameter |month= ignored (help)
  118. ^ Abel EL, Sokol RJ (1987). "Incidence of fetal alcohol syndrome and economic impact of FAS-related anomalies". Drug Alcohol Depend. 19 (1): 51–70. PMID 3545731. Retrieved 2008-05-15. {{cite journal}}: Unknown parameter |month= ignored (help)
  • Trevisan, M., et al. Drinking pattern and mortality: a longitudinal study; Gaziano, J. M., et al. A prospective cohort study of moderate alcohol consumption and sudden death in the Physicians' Health Study. Abstract . The Canadian Journal of Cardiology, June, 1997, volume 13, Supplement B.
  • Kaltourina, D., and A. Korotayev. Potential for Alcohol Policy to Decrease the Mortality Crisis in Russia // Evaluation & the Health Professions, Vol. 31, No. 3, 272-281 (2008).

External links

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