Neurophysin II: Difference between revisions
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'''Neurophysin II''' is a [[carrier protein]] which binds [[vasopressin]]. It is generated from the same precursor as vasopressin. |
'''Neurophysin II''' is a [[carrier protein]] which binds [[vasopressin]]. It is generated from the same precursor as vasopressin. |
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It can be associated with [[neurohypophyseal diabetes insipidus]].<ref name="pmid14673472">{{cite journal |vauthors=Christensen JH, Siggaard C, Corydon TJ, etal |title=Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis |journal=Eur. J. Hum. Genet. |volume=12 |issue=1 |pages=44–51 |date=January 2004 |pmid=14673472 |doi=10.1038/sj.ejhg.5201086}}</ref> |
It can be associated with [[neurohypophyseal diabetes insipidus]].<ref name="pmid14673472">{{cite journal |vauthors=Christensen JH, Siggaard C, Corydon TJ, etal |title=Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis |journal=Eur. J. Hum. Genet. |volume=12 |issue=1 |pages=44–51 |date=January 2004 |pmid=14673472 |doi=10.1038/sj.ejhg.5201086}}</ref> |
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Neurophysin II is also known as a stimulator of [[ |
Neurophysin II is also known as a stimulator of [[prolactin]] secretion. |
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== Structure == |
== Structure == |
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== Clinical significance == |
== Clinical significance == |
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Point mutations in neurophysin II underline most cases of hereditary hypothalamic [[diabetes insipidus]], a disorder resulting from insufficient [[Vasopressin|ADH]] release into systemic circulation. |
Point mutations in neurophysin II underline most cases of hereditary hypothalamic [[diabetes insipidus]], a disorder resulting from insufficient [[Vasopressin|ADH]] release into systemic circulation. |
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* {{MeshName|Neurophysin+II}} |
* {{MeshName|Neurophysin+II}} |
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{{Carrier proteins}} |
{{Carrier proteins}} |
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{{Oxytocin and vasopressin receptor modulators}} |
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Revision as of 10:56, 5 June 2016
| arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) | |||||||
|---|---|---|---|---|---|---|---|
 neurophysin II, Bos taurus | |||||||
| Identifiers | |||||||
| Symbol | AVP | ||||||
| Alt. symbols | ARVP | ||||||
| NCBI gene | 551 | ||||||
| HGNC | 894 | ||||||
| OMIM | 192340 | ||||||
| RefSeq | NM_000490 | ||||||
| UniProt | P01185 | ||||||
| Other data | |||||||
| Locus | Chr. 20 p13 | ||||||
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Neurophysin II is a carrier protein which binds vasopressin. It is generated from the same precursor as vasopressin.
It can be associated with neurohypophyseal diabetes insipidus.[1]
Neurophysin II is also known as a stimulator of prolactin secretion.
Structure
The amino acid sequence of Neurophysin II is:
NH2 - Ala - Met - Ser - Asp - Leu - Glu - Leu - Arg - Gln - Cys - Leu - Pro - Cys - Gly - Pro - Gly - Gly - Lys - Gly - Arg - Cys - Phe - Gly - Pro - Ser - Ile - Cys - Cys - Ala - Asp - Glu - Leu - Gly - Cys - Phe - Val - Gly - Thr - Ala - Glu - Ala - Leu - Arg - Cys - Gln - Glu - Glu - Asn - Tyr - Leu - Pro - Ser - Pro - Cys - Gln - Ser - Gly - Gln - Lys - Ala - Cys - Gly - Ser - Gly - Gly - Arg - Cys - Ala - Ala - Phe - Gly - Val - Cys - Cys - Asn - Asp - Glu - Ser - Cys - Val - Thr - Glu - Pro - Glu - Cys - Arg - Glu - Gly - Phe - His - Arg - Arg - Ala - OH
(Disulfide - bridge: - 10-54; - 13-27; - 21-44; - 28-34; - 61-73; - 67-85; - 74-79)
Clinical significance
Point mutations in neurophysin II underline most cases of hereditary hypothalamic diabetes insipidus, a disorder resulting from insufficient ADH release into systemic circulation.
References
- ^ Christensen JH, Siggaard C, Corydon TJ, et al. (January 2004). "Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis". Eur. J. Hum. Genet. 12 (1): 44–51. doi:10.1038/sj.ejhg.5201086. PMID 14673472.
External links
- Neurophysin+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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