Nizatidine
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| Clinical data | |
|---|---|
| Trade names | Axid |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a694030 |
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| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Bioavailability | >70% |
| Protein binding | 35% |
| Metabolism | Hepatic |
| Elimination half-life | 1-2 hours |
| Excretion | Renal |
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| ECHA InfoCard | 100.155.683 |
| Chemical and physical data | |
| Formula | C12H21N5O2S2 |
| Molar mass | 331.46 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Nizatidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). It was developed by Eli Lilly and is marketed under the brand names Tazac and Axid.
Clinical use
Nizatidine is used to treat duodenal ulcers, gastric ulcers, gastroesophageal reflux disease, and to prevent stress ulcers.[1]
Adverse effects
Side effects are uncommon, usually minor, and include diarrhea, constipation, fatigue, drowsiness, headache and muscle aches.[1]
History and development
Nizatidine was developed by Eli Lilly, and was first marketed in 1987. It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole-ring in place of the furan-ring in ranitidine. In September 2000 Eli Lilly announced they would sell the sales and marketing rights for Axid to Reliant Pharmaceuticals. [2] Subsequently, Reliant developed the oral solution of Axid, marketing this in 2004, after gaining approval from the U.S. Food and Drug Administration (FDA). [3] However, a year later they sold rights of the Axid Oral Solution (including the issued patent US6,930,119 protecting the product) to Braintree Laboratories.[4]
Nizatidine proved to be the last new histamine H2-receptor antagonist introduced prior to the advent of proton pump inhibitors.
See also
- Famotidine, aka Pepcid AC, Pepcidine: another popular H2-receptor antagonist
References
- ^ a b c U.S. National Library of Medicine Last updated: 4 November 2014 LiverTox Database: Nizatidine
- ^ Eli Lilly and Company and Reliant Pharmaceuticals Announce
- ^ Reliant Pharmaceuticals : Press Releases
- ^ Reliant Pharmaceuticals : Press Releases