β-catenin

CTNNB1
other names	Catenin (Cadherin-Associated Protein), Beta 1, 88kDa; CTNNB; MRD19; Catenin (Cadherin-Associated Protein), Beta 1 (88kD); Catenin beta-1; Beta catenin; Armadillo
	Existing structural data : 1G3J , 1JDH , 1JPW , 1LUJ , 1P22 , 1QZ7
Properties of human protein
Mass / length primary structure	781 amino acids, 85497 Da
Identifier
External IDs	GeneCards : CTNNB1 ; OMIM : 116806 ; UniProt : P35222 ;
	Orthologue

β-catenin is a structural protein involved in cell contacts and influences transcription . It plays a role in adherence contacts between cells by forming a connection between α-catenin and the cadherin complex, which ultimately leads to the connection of the actin filaments with the cadherins. In fact, this connection to α-catenin does not seem to be rigid, but rather very dynamic, as was found out in 2005.

β-catenin is homologous to plakoglobin .

literature

Jeremy M. Berg, John L. Tymoczko, Lubert Stryer : Biochemistry. 6 edition, Spektrum Akademischer Verlag, Heidelberg 2007, ISBN 978-3-8274-1800-5 .
Donald Voet, Judith G. Voet: Biochemistry. 3rd edition, John Wiley & Sons, New York 2004, ISBN 0-471-19350-X .
Bruce Alberts , Alexander Johnson, Peter Walter, Julian Lewis, Martin Raff, Keith Roberts: Molecular Biology of the Cell. 5th edition, Taylor & Francis 2007, ISBN 978-0-8153-4106-2 .

Individual evidence

↑ GS Sineva, VA Pospelov: β- Catenin in pluripotency: adhering to self-renewal or Wnting to differentiate? In: International Review of Cell and Molecular Biology. Volume 312, 2014, pp. 53-78, doi: 10.1016 / B978-0-12-800178-3.00002-6 , PMID 25262238 .

↑ Geoffrey M. Cooper: Figure 11.14 - Attachment of actin filaments to adherens junctions . In: The Cell: A Molecular Approach . 2nd Edition. Sinauer Associates, 2000, ISBN 0-87893-219-4 .

↑ Soichiro Yamada, Sabine Pokutta, Frauke Drees, William I. Weis and W. James Nelson: Deconstructing the cadherin-catenin-actin complex . In: Cell . 123, No. 5, December 2005, pp. 889-901. doi : 10.1016 / j.cell.2005.09.020 . PMID 16325582 . PMC 3368712 (free full text).

[1] GS Sineva, VA Pospelov: β- Catenin in pluripotency: adhering to self-renewal or Wnting to differentiate? In: International Review of Cell and Molecular Biology. Volume 312, 2014, pp. 53-78, doi: 10.1016 / B978-0-12-800178-3.00002-6 , PMID 25262238 .

[2] Geoffrey M. Cooper: Figure 11.14 - Attachment of actin filaments to adherens junctions . In: The Cell: A Molecular Approach . 2nd Edition. Sinauer Associates, 2000, ISBN 0-87893-219-4 .

[3] Soichiro Yamada, Sabine Pokutta, Frauke Drees, William I. Weis and W. James Nelson: Deconstructing the cadherin-catenin-actin complex . In: Cell . 123, No. 5, December 2005, pp. 889-901. doi : 10.1016 / j.cell.2005.09.020 . PMID 16325582 . PMC 3368712 (free full text).