1,6-dichlorofructose
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Surname | 1,6-dichlorofructose | |||||||||
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Molecular formula | C 6 H 10 C 12 O 4 | |||||||||
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properties | ||||||||||
Molar mass | 217.042 g mol −1 | |||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
1,6-dichlorofructose (more precisely: 1,6-dichloro-1,6-dideoxyfructose , DCDF) is a chemical compound from the group of carbohydrates .
properties
1,6-dichlorofructose is a chlorinated fructose derivative and therefore a monosaccharide . It inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and has been studied as an oral contraceptive in human spermatocytes . The hydrolysis of the chlorination in the course of the biotransformation is dependent on glutathione .
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ W. Bone, AR Jones, C. Morin, E. Nieschlag, TG Cooper: Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro. In: Journal of andrology. Volume 22, Number 3, 2001 May-Jun, pp. 464-470, PMID 11330647 .
- ^ HM Hughes, GM Powell, DJ Snodin, JW Daniel, A. Crawford, JK Sanders, CG Curtis: Glutathione-dependent dechlorination of 1,6-dichloro-1,6-dideoxyfructose. In: The Biochemical journal. Volume 259, Number 2, April 1989, pp. 537-543, PMID 2719664 , PMC 1138541 (free full text).