2-hydroxyglutaric acid
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Structural formula without stereochemistry | |||||||||||||
General | |||||||||||||
Surname | 2-hydroxyglutaric acid | ||||||||||||
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Molecular formula | C 5 H 8 O 5 | ||||||||||||
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properties | |||||||||||||
Molar mass | 148.11 g mol −1 | ||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
2-Hydroxyglutaric acid (α-hydroxyglutaric acid) is a chemical compound from the group of hydroxycarboxylic acids and is a derivative of glutaric acid .
It can be converted into α-ketoglutaric acid by the enzyme isocitrate dehydrogenase (IDH) . Hereditary disorders of this enzyme complex lead to a clinical picture known as 2-hydroxy-glutaric aciduria . Elevated levels of 2-hydroxyglutarate have been linked to the development of astrocytomas .
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Gliomas: Mutated enzyme drives cancer growth. (htm) Deutsches Ärzteblatt , November 23, 2009, archived from the original on February 5, 2010 ; Retrieved June 6, 2010 .
- ↑ Lenny Dang et al., Agios Pharmaceuticals, Cambridge, MA: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate , in: Nature , December 10, 2009; 462 (7274), pp. 739-744, doi: 10.1038 / nature08617 , PMID 19935646 ; PMC 2818760 (free full text, PDF)