8-hydroxy deoxyguanosine

Structural formula
General
Surname	8-hydroxy deoxyguanosine
other names	8-oxo-2'-deoxyguanosine; 8-Oxo-dG; 2-Amino-9 - [(2 R , 4 S , 5 R ) -4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -3,7-dihydropurine-6,8-dione ( IUPAC ) ;
Molecular formula	C 10 H 13 N 5 O 5
External identifiers / databases
PubChem	135440064
ChemSpider	66049
DrugBank	DB02502
Wikidata	Q270154
properties
Molar mass	283.24 g mol −1
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

8-Hydroxydesoxyguanosine or 8-OHdG is a nucleoside and a derivative of deoxyguanosine . It is an easily measurable biomarker (usually in the morning urine ) for oxidative stress and the efficiency of the corresponding repair system. For example, increases in concentration in the urine of smokers , when working with a computer screen , a variety of diseases, including cancer, but also in the brains of Parkinson's patients.

The detection of concentration reductions serves u. a. to prove the protective antioxidant properties of drugs such as carvedilol or the epigallocatechin gallate (EGCG) contained in green tea . The analytical detection of 8-OHdG is carried out up to the femto-molar concentration range by HPLC with a coupled electrochemical detector , but GC-MS and ELISA methods have also been described.

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
^ S. Wolfram: Effects of green tea and EGCG on cardiovascular and metabolic health. In: Journal of the American College of Nutrition . Volume 26, Number 4, August 2007, pp. 373S-388S, PMID 17906191
↑ Miral Dizdaroglu, Ali Esat Karakaya: Advances in DNA damage and repair: oxygen radical effects, cellular protection and biological consequences. , Kluwer Academic, New York, 1999. ISBN 0-306-46042-4 ( limited preview in Google book search), pp. 398-402.

[NV-1] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[2] S. Wolfram: Effects of green tea and EGCG on cardiovascular and metabolic health. In: Journal of the American College of Nutrition . Volume 26, Number 4, August 2007, pp. 373S-388S, PMID 17906191

[3] Miral Dizdaroglu, Ali Esat Karakaya: Advances in DNA damage and repair: oxygen radical effects, cellular protection and biological consequences. , Kluwer Academic, New York, 1999. ISBN 0-306-46042-4 ( limited preview in Google book search), pp. 398-402.