Subunit 2 of the Arp 2/3 complex
| Subunit 2 of the Arp 2/3 complex | ||
|---|---|---|
|
||
| other names |
p34-ARC |
|
| Properties of human protein | ||
| Mass / length primary structure | 34.3 kDa / 300 amino acids | |
| Cofactor | Actin | |
| Isoforms | n / A | |
| Identifier | ||
| Gene names | ARPC2 ARC34, PRO2446 | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 10109 | 76709 |
| Ensemble | ENSG00000163466 | ENSMUSG00000006304 |
| UniProt | O15144 | Q9CVB6 |
| Refseq (mRNA) | NM_005731 | NM_029711 |
| Refseq (protein) | NP_005722 | NP_083987 |
| Gene locus | Chr 2: 218.22 - 218.25 Mb | Chr 1: 74.24 - 74.27 Mb |
| PubMed search | 10109 |
76709
|
The subunit 2 of the Arp 2/3 complex , short- p34-ARC or even p34 (due to the molecular mass of nearly 34 kDa ) is a structural protein and one of seven subunits of the Arp 2/3 complex . The protein is encoded by the ARPC2 gene on human chromosome 2 .
function
Subunit 2 of the Arp 2/3 complex interacts with six other proteins ( Arp2 , Arp3 , p16 , p20 , p21 and p40 ) and forms a protein complex with them , which plays an important role in the nucleation of actin filaments . With its subunits Arp2 and 3 , the complex mimics an actin dimer , which is more stable than the dimer itself and thus serves as a center for the further polymerization of G- to F-actin. The exact role of the p34 subunit is not yet known, but the protein seems to be able to bind to actin, which is important for the activation of the complex and for the formation of Y-branched actin filaments.
Individual evidence
- ↑ a b ARPC2
- ↑ a b Julia Ehinger: Characterization of Arp 2/3 complex mediated actin reorganization during the invasion of bacterial pathogens , Carolo-Wilhelmina University of Braunschweig, February 20, 2006, p. 9f. (Dissertation to obtain the degree of doctorate in natural sciences).
- ↑ UniProt O15144