Subunit 5 of the Arp 2/3 complex

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Subunit 5 of the Arp 2/3 complex
Subunit 5 of the Arp 2/3 complex
other names

p16-ARC

Properties of human protein
Mass / length primary structure 16.3 kilodaltons / 151 amino acids (isoform 1)

16.6 kilodaltons / 154 amino acids (isoform 2)

Isoforms 2
Identifier
Gene names ARPC5 ARC16
External IDs
Orthologue
human House mouse
Entrez 10092 67771
Ensemble ENSG00000162704 ENSMUSG00000008475
UniProt O15511 Q9CPW4
Refseq (mRNA) NM_001270439 NM_026369
Refseq (protein) NP_001257368 NP_080645
Gene locus Chr 1: 183.63 - 183.64 Mb Chr 1: 152.77 - 152.78 Mb
PubMed search 10092 67771

The subunit 5 of the Arp 2/3 complex , abbreviated p16-ARC or just p16 (because of the molar mass of around 16 kDa) is a structural protein and together with six other proteins forms the Arp 2/3 complex . The protein is encoded by the ARPC5 gene on the first human chromosome .

function

The subunit 5 of the Arp 2/3 complex interacts with the proteins Arp2 , Arp3 , p21 , p20 , p34 and p40 and together with them forms the Arp 2/3 complex, which plays an important role in the formation of actin filaments from G- Actin plays. The complex acts namely as a center for further actin nucleation by an actin dimer mimics the two subunits Arp 2 and 3, but it is more stable than the dimer itself. The exact role of subunit 5 in this complex or other functions of this protein are not yet known.

Individual evidence

  1. ↑ a b Julia Ehinger: Characterization of Arp 2/3 complex mediated actin reorganization during the invasion of bacterial pathogens , Carolo-Wilhelmina University of Braunschweig, February 20, 2006, p. 9f. (Dissertation to obtain the degree of doctorate in natural sciences)
  2. ↑ a b ARPC5 .