Actin-like protein 3

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Actin-like protein 3 (ARP3)
Actin-like protein 3 (ARP3)
Properties of human protein
Mass / length primary structure 47.4 kilodaltons / 418 amino acids
Isoforms 2
Identifier
Gene names ACTR3 ARP3
External IDs
Orthologue
human House mouse
Entrez 10096 74117
Ensemble ENSG00000115091 ENSMUSG00000026341
UniProt P61158 Q99JY9
Refseq (mRNA) NM_001277140 NM_001205385
Refseq (protein) NP_001264069 NP_001192314
Gene locus Chr 2: 113.89 - 113.96 Mb Chr 1: 125.39 - 125.44 Mb
PubMed search 10096 74117

The actin-like protein 3 , abbreviated ARP 3 , from the English actin related protein , a structural protein with a large structural homology to G- actin . It is encoded by the ACTR3 gene on the second human chromosome .

function

The protein interacts with actin-like protein 2 , p16 , p20 , p21 , p34 and p40 to form the Arp 2/3 complex, which plays an important role in actin nucleation and thus in cell mobility. The complex forms a nucleation center from which the further polymerization of G-action to F-actin takes place, and the actin filament is thus lengthened. It is assumed that the special ARP3 and 3 imitate an actin dimer, but are more stable than the dimer itself and thus serve as the basis for nucleation. ARP 3 is therefore mainly localized on the cytoskeleton, especially on pseudopodia .

Individual evidence

  1. ↑ a b Julia Ehinger: Characterization of Arp 2/3 complex mediated actin reorganization during the invasion of bacterial pathogens , Carolo-Wilhelmina University of Braunschweig, February 20, 2006, p. 9f. (Dissertation to obtain the degree of doctorate in natural sciences)
  2. ↑ ACTR3 .
  3. ↑ UniProt P61158