Actin-like protein 2

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Actin-like protein 2 (Arp2)
Actin-like protein 2 (Arp2)
according to PDB  1K8K
Properties of human protein
Mass / length primary structure 44.8 kilodaltons / 394 amino acids (isoform 1)

45.4 kilodaltons / 399 amino acids (isoform 2)

Isoforms 2
Identifier
Gene names ACTR2 ARP2
External IDs
Orthologue
human House mouse
Entrez 10097 66713
Ensemble ENSG00000138071 ENSMUSG00000020152
UniProt P61160 P61161
Refseq (mRNA) NM_001005386 NM_146243
Refseq (protein) NP_001005386 NP_666355
Gene locus Chr 2: 65.23 - 65.27 Mb Chr 11: 20.06 - 20.11 Mb
PubMed search 10097 66713

The actin-related protein 2 , abbreviated ARP 2 from English Actin related protein 2 , is a protein that the large structural homology to G- actin has. It is encoded by the ACTR2 gene on the second human chromosome . Actin-like protein 2 is one of the seven subunits of the Arp 2/3 complex . Further functions are not yet known.

function

The protein interacts with actin-like protein 3 , p16 , p20 , p21 , p34 and p40 to form the Arp 2/3 complex, which plays an important role in actin nucleation and thus in cell mobility. The complex forms a nucleation center from which the further polymerization of G-action to F-actin takes place, and the actin filament is thus lengthened. It is assumed that the specifically ARP2 and 3 imitate an actin dimer, but are more stable than the dimer itself and thus serve as the basis for nucleation. ARP 2 is therefore mainly localized on the cytoskeleton, especially on pseudopodia .

Individual evidence

  1. ↑ ACTR2
  2. ↑ a b Julia Ehinger: Characterization of Arp 2/3 complex mediated actin reorganization during the invasion of bacterial pathogens , Carolo-Wilhelmina University of Braunschweig, February 20, 2006, p. 9f. (Dissertation to obtain the degree of doctorate in natural sciences).
  3. ↑ UniProt P61160