Actin-like protein 3
Actin-like protein 3 (ARP3) | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 47.4 kilodaltons / 418 amino acids | |
Isoforms | 2 | |
Identifier | ||
Gene names | ACTR3 ARP3 | |
External IDs | ||
Orthologue | ||
human | House mouse | |
Entrez | 10096 | 74117 |
Ensemble | ENSG00000115091 | ENSMUSG00000026341 |
UniProt | P61158 | Q99JY9 |
Refseq (mRNA) | NM_001277140 | NM_001205385 |
Refseq (protein) | NP_001264069 | NP_001192314 |
Gene locus | Chr 2: 113.89 - 113.96 Mb | Chr 1: 125.39 - 125.44 Mb |
PubMed search | 10096 |
74117
|
The actin-like protein 3 , abbreviated ARP 3 , from the English actin related protein , a structural protein with a large structural homology to G- actin . It is encoded by the ACTR3 gene on the second human chromosome .
function
The protein interacts with actin-like protein 2 , p16 , p20 , p21 , p34 and p40 to form the Arp 2/3 complex, which plays an important role in actin nucleation and thus in cell mobility. The complex forms a nucleation center from which the further polymerization of G-action to F-actin takes place, and the actin filament is thus lengthened. It is assumed that the special ARP3 and 3 imitate an actin dimer, but are more stable than the dimer itself and thus serve as the basis for nucleation. ARP 3 is therefore mainly localized on the cytoskeleton, especially on pseudopodia .