Subunit 3 of the Arp 2/3 complex

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Subunit 3 of the Arp 2/3 complex
Subunit 3 of the Arp 2/3 complex
other names

p21

Existing structural data : 2P9N , 1TYQ , 1U2V , 4JD2 , 3DXK , 3UKU , 3UKR , 2P9P , 2P9K , 2P9U , 3ULE , 3RSE , 2P9S , 2P9I , 4XF2 , 2P9L , 1K8K , 3DXM , 4XEI

Properties of human protein
Mass / length primary structure 20.5 kilodaltons / 178 amino acids
Identifier
Gene names ARPC3 ARC21, p21-ARC
External IDs
Orthologue
human House mouse
Entrez 10094 56378
Ensemble ENSG00000111229 ENSMUSG00000029465
UniProt O15145 Q9JM76
Refseq (mRNA) NM_001278556 NM_019824
Refseq (protein) NP_001265485 NP_062798
Gene locus Chr 12: 110.43 - 110.45 Mb Chr 5: 122.39 - 122.41 Mb
PubMed search 10094 56378

The sub unit 3 of the Arp 2/3 complex , shortened p21-ARC or even p21 (because of the molar mass of about 21 kDa), is a structural protein and as such, one of seven subunits of the Arp 2/3 complex . The protein is encoded by the ARPC3 gene on human 12th chromosome .

function

Subunit 3 of the Arp 2/3 complex interacts with the proteins Arp2 , Arp3 , p16 , p20 , p34 and p40 and together with them forms the Arp 2/3 complex, which plays an important role in the formation of actin filaments from G- Actin plays. The complex acts namely as a center for further actin nucleation by an actin dimer mimics the two subunits Arp 2 and 3, but it is more stable than the dimer itself. For activation of the complex, however, "Nucleation promoting factors (NPFs)" still have to bind to four subunits of the complex and to actin. The p21 subunit has such a binding site.

Individual evidence

  1. ↑ a b Julia Ehinger: Characterization of Arp 2/3 complex mediated actin reorganization during the invasion of bacterial pathogens , Carolo-Wilhelmina University of Braunschweig, February 20, 2006, p. 9f. (Dissertation to obtain the degree of doctorate in natural sciences)
  2. ↑ ARPC3
  3. ↑ UniProt O15145