Ana Claudia Zenclussen

Ana Claudia Zenclussen

Ana Claudia Zenclussen (* 1971 in Esperanza , Argentina ) is a German-Argentinian immunologist. She conducts research in the field of pregnancy immunology and heads the Experimental Gynecology and Obstetrics department at Otto von Guericke University Magdeburg .

Life

Ana Zenclussen studied biochemistry in Santa Fe, Argentina, from 1990 to 1996 and received her doctorate in 2001 with distinction in the field of immunology (focus on fetomaternal immunology) at the University of Buenos Aires . Her research was recognized by a subsequent grant from the Alexander von Humboldt Foundation , with which she continued her work at the Charité in Berlin. In May 2007 Ana Zenclussen followed the call to Magdeburg and has since been a university professor for experimental gynecology and obstetrics at the Medical Faculty of Otto von Guericke University Magdeburg . Ana Zenclussen is married and has two children.

Researches

Ana Zenclussen researches the mechanisms that lead to pregnancy success. The main projects include the tolerance mechanisms during pregnancy and the immunological complications of pregnancy ( miscarriage and preeclampsia ).

The immune system during pregnancy must at the same time tolerate the paternal, foreign antigens of the embryo and protect the mother from impending infections. This is achieved thanks to a finely regulated modulation of the maternal immune system, in which a large number of cells or mediators are involved. For this purpose, the influence of different cell types of the innate and adaptive immune system on decisive reproductive processes, such as folliculogenesis, the oestrus or menstrual cycle, the implantation of the blastocyst in the maternal endometrium , the decidualization and placentation is examined.

Molecular biological and immunological methods, including immunohistochemistry , immunocytochemistry, immunofluorescence , 2-photon microscopy, real-time RT-PCR , siRNA , Western blot , flow cytometry , ELISA, are used to research these mechanisms . Different mouse models allow an investigation of the processes in vivo . In vitro experiments are used to research the migration, proliferation and interaction behavior of different cell types. These cells are derived from various organs such as B. isolated from the uterus , as well as generated from bone marrow precursor cells. In addition, several cell lines are employed (human and murine Trophoblastenzelllinien , HUVEC, human mast cell lines , B-cell line , Leydig cell line ). Both murine and human placental tissue are available for ex vivo experiments. This also makes it possible to examine the immunological background of various pregnancy complications in humans, such as preeclampsia .

Your research work is documented in around 100 international publications. Ana Zenclussen and her team in the field of gynecology and obstetrics are among the top 10 most cited papers from 2009 to 2013.

Memberships and honors

Memberships

• Chair of the Young Talent Commission, FME, OVGU , Magdeburg
• Member of the research commission, FME, OVGU, Magdeburg
• German Society for Immunology
• Humboldtdianer Club (Alexander von Humboldt Alumni)
• International Society for Reproductive Immunology
• European Society for Reproductive Immunology
• European Mast Cell and Basophil Research Network (EMBRN)
• American Association of Immunologists
• Society for Reproduction and Fertility
• Honorary member, Sociedad Argentina de Biología

Awards

• New Investigator Award for: "Introducing a Novel Model for Pre-eclampsia", from: American Society of Reproductive Immunology. Chicago, June 2002
• Certificate of Excellence for “Heme Oxygenases (HOs) in pregnancy II”: “HO-2 expression is downregulated in pathologic pregnancy placentas”, from: American Society of Reproductive Immunology, Chicago, June 2002
• PhD students of the AG (Sollwedel, Zambon Bertoja and Zenclussen ML) receive Young Investigator Award in Japan (9th International Congress of Reproductive Immunology), 2004
• Support of the Swedish GEMI-Fund, a foundation of the company Linde Gas Therapeutics, in the amount of 155,000 US dollars, 2007–2009
• Manuscript “Zenclussen et al., Am J Pathol 2005” 3rd most cited article by German scientists in reproductive biology (Labor Journal), 2011

Selected publications

• Nicole Meyer, Katja Woidacki, Martin Knöfler, Gudrun Meinhardt, Désirée Nowak, Philipp Velicky, Jürgen Pollheimer, Ana C. Zenclussen: Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth . In: Springer Nature (Ed.): Scientific Reports . tape 7 , no. 45106 , March 2, 2017, doi : 10.1038 / srep45106 .
• Franziska Fettke, Anne Schumacher, Andrea Canellada, Natalia Toledo, Isabelle Bekeredjian-Ding, Albert Bondt, Manfred Wuhrer, Serban-Dan Costa, Ana Claudia Zenclussen: Maternal and Fetal Mechanisms of B Cell Regulation during Pregnancy: Human Chorionic Gonadotropin Stimulates B Cells to Produce IL-10 While Alpha-Fetoprotein Drives Them into Apoptosis . In: Frontiers Media SA (Ed.): Frontiers in Immunology . tape 7 , December 8, 2016, doi : 10.3389 / fimmu.2016.00495 .
• A. Schumacher, K. Heinze, J. Witte, E. Poloski, N. Linzke, K. Woidacki, AC Zenclussen: Human Chorionic Gonadotropin as a Central Regulator of Pregnancy Immune Tolerance . In: The American Association of Immunologists (Ed.): The Journal of Immunology . tape 190 , no. 6 , February 8, 2013, p. 2650-2658 , doi : 10.4049 / jimmunol.1202698 .
• Maria Laura Zenclussen, Pablo Ariel Casalis, Tarek El-Mousleh, Sofia Rebelo, Stefanie Langwisch, Nadja Linzke, Hans-Dieter Volk, Stefan Fest, Miguel Parreira Soares, Ana Claudia Zenclussen: Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide . In: Wiley-Blackwell (Ed.): The Journal of Pathology . tape 225 , no. 2 , July 8, 2011, p. 293-304 , doi : 10.1002 / path.2946 .
• Ana Claudia Zenclussen, Katrin Gerlof, Maria Laura Zenclussen, André Sollwedel, Annarosa Zambon Bertoja, Thomas Ritter, Katja Kotsch, Joachim Leber, Hans-Dieter Volk: Abnormal T-Cell Reactivity against Paternal Antigens in Spontaneous Abortion . In: Elsevier BV (Ed.): The American Journal of Pathology . tape 166 , no. 3 , March 2005, p. 811-822 , doi : 10.1016 / s0002-9440 (10) 62302-4 .

Web links

• Publications by Zenclussen at PubMed
• Chair page of the Department of Experimental Gynecology and Obstetrics
• Professor portrait page at the Otto von Guericke University Magdeburg
• Portrait page in the research portal Saxony-Anhalt

Individual evidence

1. ↑ Alexander von Humboldt Foundation - Research in the Network. Retrieved August 21, 2017 . 
2. ↑ Harrald Benninger: Institute of Medical Immunology - Charité - University Medicine Berlin: Publications. Retrieved August 21, 2017 . 
3. ^ Stadtmarekting Pro Magdeburg eV: researchers, thinkers and inventors - scientists for Magdeburg. Retrieved August 21, 2017 . 
4. ↑ corona labs - design agency: Leibniz Institute for Neurobiology: 2014-08-11 - Women's Career Day 2014. Accessed on August 21, 2017 (English). 
5. ↑ Biermann Medicine: Do environmental factors influence reproductive medicine ? | Biermann medicine news portal. (No longer available online.) Formerly in the original ; accessed on August 21, 2017 (German).  ( Page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.    
6. ↑ Josephina Maier: Therapeutic use: The good thing about poison . In: The time . August 25, 2011, ISSN  0044-2070 ( zeit.de [accessed on August 21, 2017]).
7. ↑ Ulrike Gebhardt: Complications in Pregnancy: Immune Cells in the Service of Reproduction . In: Neue Zürcher Zeitung . January 23, 2013, ISSN  0376-6829 ( nzz.ch [accessed on August 21, 2017]).
8. ↑ Heroes of reproduction: the mast cell | IMMUNE. Retrieved on August 21, 2017 (German). 
9. ↑ Professor Dr. Ana Claudia Zenclussen Archives - Die Zeit-online. Retrieved on August 21, 2017 (German). 
10. ↑ Laborjournal: Laborjournal online: Citation comparison 2009-2013: Reproduction research. Retrieved August 21, 2017 . 
11. ↑ Gusdon Award | Zenclussen 2002. (No longer available online.) Archived from the original on September 15, 2017 ; accessed on August 22, 2017 (English). Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.  
12. ↑ Pregnancy immunology studies are funded. Retrieved August 22, 2017 .