Andrea Kühn

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Andrea Kühn (born December 17, 1970 in Budapest ) is a German neurologist and neuroscientist in the field of movement disorders and neuromodulation at the Berlin Charité .

Life

Andrea Kühn studied human medicine from 1990 to 1998 (from 1993 with support from the German National Academic Foundation ) at the Charité , Humboldt University in Berlin and the University of Nancy I in France. In 1998 she did her doctorate at the Charité Berlin. med. with the work Magnetic stimulation of the motor cortex of humans: topography and current direction dependence of corticospinal and callosal mediated stimulus effects, in 2000 she received her license to practice medicine . From 2002 to 2007 she worked as a postdoctoral fellow with Peter Brown at the Institute of Neurology, Sobell Department of Motor Neuroscience and Movement Disorders at University College London . In 2006 she acquired the field title (specialist) for neurology. In 2007 she became head of the clinical work group movement disorders and deputy head of the special outpatient department for movement disorders at the Charité and in the same year junior professor for neurological movement disorders at the Clinic for Neurology at the Charité. She has been a senior physician at the Department of Neurology since 2010, and in the same year she became head of a clinical research group of the German Research Foundation . In 2012 Kühn became a full professor at the Clinic for Neurology at the Charité.

Kühn received a W3 professorship at the Charité in 2016 and took over the management of the newly established section for neuromodulation and movement disorders at the Department of Neurology on Campus Mitte. In 2020 she became the spokesperson for the Transregio Collaborative Research Center 295 Retune in cooperation with the University Hospital Würzburg , the University Hospital Düsseldorf , the University of Rostock and the Hebrew University of Jerusalem . Kühn's focus lies both clinically and scientifically on the treatment of movement disorders with the method of deep brain stimulation .

Act

Kühn's working group focuses on the characterization of physiomarkers in local field potentials in patients with movement disorders such as idiopathic Parkinson's syndrome . The cornerstone of the research is pathologically increased synchronization in the beta frequency range of the basal ganglia- cortex loop. This physiomarker correlates with the severity of bradykinetic and rigid symptoms of Parkinson's disease and is now established. Andrea Kühn's work in collaboration with Peter Brown is considered pioneering in this regard. Building on this, the working group deals with the development of so-called closed-loop systems in the field of deep brain stimulation. Multimodal modern methods are used here, for example the invasive derivation of subcortical and cortical ( electrocorticography ) field potentials. In addition, Kühn's group is methodically concerned with electroencephalography , functional magnetic resonance tomography , diffusion-weighted fiber tractography and structural magnetic resonance tomography .

Awards (selection)

Publications (selection)

  • B. Al-Fatly, S. Ewert, D. Kübler, D. Kroneberg, Andreas Horn, Andrea A. Kühn: Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor . Brain. 2019; pii: awz236. DOI: 10.1093 / brain / awz236.
  • Andreas Horn, Gregor Wenzel, F. Irmen, Julius Hübl, N. Li, Wolf-Julian Neumann, P. Krause, G. Bohner, M. Scheel, Andrea A. Kühn: Deep Brain Stimulation induced normalization of the human functional connectome in Parkinson's Disease . Brain 2019. doi: online IF 11.814
  • R. Lofredi, Wolf-Julian Neumann, A. Bock, Andreas Horn, Julius Hübl, S. Siegert, Gerd-Helge Schneider, JK Krauss, Andrea A. Kühn: Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson's disease . Elife. February 1, 2018; 7. pii: e31895. doi: 10.7554 / eLife.31895.
  • Wolf-Julian Neumann, Andreas Horn, S. Ewert, Julius Hübl, Christof Brücke, C. Slentz, Gerd-Helge Schneider, Andrea A. Kühn: A localized pallidal physiomarker in cervical dystonia . Ann Neurol. 2017 Dec; 82 (6): 912-924.
  • EA Accolla, Ruiz M. Herrojo, Andreas Horn, Gerd-Helge Schneider, T. Schmitz-Hübsch, B. Draganski, Andrea A. Kühn: Brain networks modulated by subthalamic nucleus deep brain stimulation . Brain. 2016; 139 (Pt 9): 2503-15.
  • Wolf-Julian Neumann, A. Jha, A. Bock, Julius Hübl, Andreas Horn, Gerd-Helge Schneider, TH Sander, V. Litvak, Andrea A. Kühn: Cortico-pallidal oscillatory connectivity in patients with dystonia . Brain 2015; 138 (Pt 7): 1894-906.
  • E. Barow, Wolf-Julian Neumann, C. Brucke, Julius Hübl, Andreas Horn, Peter Brown, JK Krauss, Gerd-Helge Schneider, AA Kuhn: Deep b stimulation suppresses pallidal low frequency activity in patients with phasic dystonic movements . B 2014; 137 (Pt 11): 3012-24.

Web links

  • Internet presence of the Movement Disorders and Neuromodulation Section at the Charité (headed by A. Kühn)

Individual evidence

  1. ↑ Andrea A. Kühn, Florian Kempf, Christof Brücke, Louise Gaynor Doyle, Irene Martinez-Torres: High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory β Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance . In: Journal of Neuroscience . tape 28 , no. 24 , June 11, 2008, ISSN  0270-6474 , p. 6165–6173 , doi : 10.1523 / JNEUROSCI.0282-08.2008 , PMID 18550758 , PMC 6670522 (free full text) - ( jneurosci.org [accessed on August 16, 2020]).
  2. ↑ Wolf-Julian Neumann, Franziska Staub-Bartelt, Andreas Horn, Julia Schanda, Gerd-Helge Schneider: Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson's disease . In: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology . tape 128 , no. November 11 , 2017, ISSN  1872-8952 , p. 2286–2291 , doi : 10.1016 / j.clinph.2017.08.028 , PMID 29031219 , PMC 5779610 (free full text).
  3. ↑ Wolf-Julian Neumann, Andrea A. Kühn: Subthalamic beta power-Unified Parkinson's disease rating scale III correlations require akinetic symptoms . In: Movement Disorders: Official Journal of the Movement Disorder Society . tape 32 , no. 1 , January 2017, ISSN  1531-8257 , p. 175-176 , doi : 10.1002 / mds.26858 , PMID 27859569 .
  4. ↑ Andrea A. Kühn, Louise Doyle, Alek Pogosyan, Kielan Yarrow, Andreas Kupsch: Modulation of beta oscillations in the subthalamic area during motor imagery in Parkinson's disease . In: Brain . tape 129 , no. 3 , March 1, 2006, ISSN  0006-8950 , p. 695–706 , doi : 10.1093 / brain / awh715 ( oup.com [accessed August 16, 2020]).
  5. ↑ Andreas Horn, Gregor Wenzel, Friederike Irmen, Julius Hübl, Ningfei Li: Deep brain stimulation induced normalization of the human functional connectome in Parkinson's disease . In: Brain . tape 142 , no. 10 , October 1, 2019, ISSN  0006-8950 , p. 3129–3143 , doi : 10.1093 / brain / awz239 ( oup.com [accessed on August 16, 2020]).
  6. ↑ Friederike Irmen, Andreas Horn, Philip Mosley, Alistair Perry, Jan Niklas Petry ‐ Schmelzer: Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms . In: Annals of Neurology . tape 87 , no. 6 , 2020, ISSN  1531-8249 , p. 962-975 , doi : 10.1002 / ana.25734 ( wiley.com [accessed August 16, 2020]).
  7. ↑ Andreas Horn, Andrea A. Kühn: Lead-DBS: a toolbox for deep brain stimulation electrode localizations and visualizations . In: NeuroImage . tape 107 , February 15, 2015, ISSN  1095-9572 , p. 127–135 , doi : 10.1016 / j.neuroimage.2014.12.002 , PMID 25498389 .
personal data
SURNAME Bold, Andrea
BRIEF DESCRIPTION German neurologist
DATE OF BIRTH 17th December 1970
PLACE OF BIRTH Budapest