Androgen binding protein

Androgen binding protein
Properties of human protein
Identifier
Gene name	ABP
External IDs	OMIM : 182205 ; UniProt : P04278 ;

Androgen-binding protein (ABP) is a glycoprotein (beta globulin) produced by the Sertoli cells of the testis and which binds the androgens testosterone , dihydrotestosterone and estradiol . It binds these hormones in the ductus deferens and the testicular tubules . It has the same amino acid sequence as the sex hormone binding globulin , which is responsible for blood transport, but it is glycosylated differently .

As a result of the binding, the hormones testosterone and dihydrotestosterone become less lipophilic and can thus accumulate in the luminal fluid of the testicular tubules. This enables spermatogenesis and sperm maturation in the epididymis .

Individual evidence

↑ S. Gershagen, A. Lundwall, P. Fernlund: Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis. In: Nucleic acids research. Volume 17, Number 22, November 1989, pp. 9245-9258, PMID 2587256 . PMC 335128 (free full text).
↑ GL Hammond, DA Underhill, HM Rykse, CL Smith: The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs. In: Molecular endocrinology (Baltimore, Md.). Volume 3, Number 11, November 1989, pp. 1869-1876, PMID 2608061 .

[1] S. Gershagen, A. Lundwall, P. Fernlund: Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis. In: Nucleic acids research. Volume 17, Number 22, November 1989, pp. 9245-9258, PMID 2587256 . PMC 335128 (free full text).

[2] GL Hammond, DA Underhill, HM Rykse, CL Smith: The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs. In: Molecular endocrinology (Baltimore, Md.). Volume 3, Number 11, November 1989, pp. 1869-1876, PMID 2608061 .