Bisindolyl maleimide 4

Structural formula
General
Surname	Bisindolyl maleimide 4
other names	Ro31-6233; Arcyriarubin A.; Bis [3,4- (1 H -indol-3-yl) -1 H ] -pyrrole-2,5-dione;
Molecular formula	C 20 H 13 N 3 O 2
Brief description	red solid
External identifiers / databases
PubChem	2399
Wikidata	Q27075304
properties
Molar mass	327.34 g mol −1
Physical state	firmly
Melting point	161 ° C
solubility	soluble in DMSO
safety instructions
GHS labeling of hazardous substances	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Bisindolylmaleimide 4 is a chemical compound from the group of bisindolylmaleimides and their basic compound .

Occurrence

Bisindolylmaleimide 4 occurs naturally in myxomycetes (slime molds) Arcyria major or Arcyria denudata . Myxomycetes produce a number of other bisindolyl derivatives.

Extraction and presentation

Bisindolyl maleimide 4 can be obtained by reacting dichloromaleimide or dibromomaleimide with indolylmagnesium bromide.

properties

Bisindolyl maleimide 4 is a red solid that is soluble in DMSO . It is a protein kinase C inhibitor.

use

Bisindolylmaleimide 4 can be used to produce other chemical compounds (for example staurosporirone ).

Individual evidence

↑ ^a ^b ^c Burkhard Fugmann: RÖMPP Lexikon Naturstoffe, 1st edition, 1997 . Georg Thieme Verlag, 2014, ISBN 3-13-179541-7 , p. 103 ( limited preview in Google Book search).
↑ ^a ^b ^c ^d ^e data sheet bisindolylmaleimide IV, ≥98% (TLC), solid from Sigma-Aldrich , accessed on July 14, 2017 ( PDF ).
↑ Steglich, W. (1989): Slime molds (Myxomycetes) as a source of new biologically active metabolites . In: Pure Appl. Chem. , 61 (3); 281-288; doi : 10.1351 / pac198961030281 ; PDF (free full text, English)
↑ ^a ^b Krishna C. Majumdar, Shital K. Chattopadhyay: Heterocycles in Natural Product Synthesis . John Wiley & Sons, 2011, ISBN 3-527-63489-4 , pp. 119 ( limited preview in Google Book search).
^ Chemistry and Pharmacology . Academic Press, 1995, ISBN 978-0-08-086571-3 , pp. 203 ( limited preview in Google Book search).
^ John Buckingham, Keith H. Baggaley, Andrew D. Roberts, Laszlo F. Szabo: Dictionary of Alkaloids, Second Edition with CD-ROM . CRC Press, 2010, ISBN 978-1-4200-7770-4 , pp. 216 ( limited preview in Google Book search).

[Burkhard_Fugmann-1] Burkhard Fugmann: RÖMPP Lexikon Naturstoffe, 1st edition, 1997 . Georg Thieme Verlag, 2014, ISBN 3-13-179541-7 , p. 103 ( limited preview in Google Book search).

[Sigma-2] ↑ ^a ^b ^c ^d ^e data sheet bisindolylmaleimide IV, ≥98% (TLC), solid from Sigma-Aldrich , accessed on July 14, 2017 ( PDF ).

[3] Steglich, W. (1989): Slime molds (Myxomycetes) as a source of new biologically active metabolites . In: Pure Appl. Chem. , 61 (3); 281-288; doi : 10.1351 / pac198961030281 ; PDF (free full text, English)

[Krishna_C._Majumdar,_Shital_K._Chattopadhyay-4] Krishna C. Majumdar, Shital K. Chattopadhyay: Heterocycles in Natural Product Synthesis . John Wiley & Sons, 2011, ISBN 3-527-63489-4 , pp. 119 ( limited preview in Google Book search).

[5] Chemistry and Pharmacology . Academic Press, 1995, ISBN 978-0-08-086571-3 , pp. 203 ( limited preview in Google Book search).

[John_Buckingham,_Keith_H._Baggaley,_Andrew_D._Roberts,_Laszlo_F._Szabo-6] John Buckingham, Keith H. Baggaley, Andrew D. Roberts, Laszlo F. Szabo: Dictionary of Alkaloids, Second Edition with CD-ROM . CRC Press, 2010, ISBN 978-1-4200-7770-4 , pp. 216 ( limited preview in Google Book search).