Argininosuccinate

Structural formula
Natural L- argininosuccinate
General
Surname	Argininosuccinate
Molecular formula	C 10 H 18 N 4 O 6
External identifiers / databases
CAS number 2387-71-5 918149-29-8 ( disodium salt ) PubChem 16950 ChemSpider 16059 DrugBank DB02267 Wikidata Q424590
properties
Molar mass	290.27 g mol −1
Physical state	firmly
safety instructions
GHS labeling of hazardous substances Disodium salt no GHS pictograms H and P phrases H: no H-phrases P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Argininosuccinate is a non-proteinogenic amino acid . The L - isomer is an intermediate product in the urea cycle and is formed there from citrulline and aspartate, catalyzed by argininosuccinate synthase with consumption of ATP . In the further course of the cycle, argininosuccinate is broken down into fumarate and arginine by the argininosuccinate lyase .

On the other hand, the argininosuccinate can also first be converted into fumarate and then into malate , which can be fed into the citric acid cycle . In this respect, argininosuccinate is an important link between the urea cycle and the citric acid cycle.

Individual evidence

1. ↑ ^{a b} Data sheet Argininosuccinic acid disodium salt hydrate, ≥80% from Sigma-Aldrich , accessed on January 29, 2013 ( PDF ).
2. ↑ Florian Horn: Biochemistry of the people: The textbook for medical studies . Georg Thieme Verlag, 2012, ISBN 3-13-151345-4 , p. 192 ( limited preview in Google Book search).
3. ↑ Gerd P. Püschel, Hartmut Kühn, Thomas Kietzmann, Wolfgang Höhne: pocket textbook biochemistry . Georg Thieme Verlag, 2011, ISBN 3-13-165971-8 , p. 77 ( limited preview in Google Book search).
4. ^ Joachim Rassow, Karin Hauser, Rainer Deutzmann, Roland Netzker: Dual Biochemistry Series . Georg Thieme Verlag, 2012, ISBN 3-13-152103-1 , p. 141 ( limited preview in Google Book search).
5. ^ Lehninger: Lehninger Principles of Biochemistry . WH Freeman and Company, 2013.