Autophagin 4A
| Cysteine protease ATG4A | ||
|---|---|---|
| other names |
AUT-like 2 cysteine endopeptidase, autophagin-2, autophagy-related cysteine endopeptidase 2, autophagy-related protein 4 homologous A, hAPG4A |
|
| Properties of human protein | ||
| Mass / length primary structure | 398 amino acids , 45,378 Da | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.4.22.- | |
| Orthologue (human) | ||
| Entrez | 115201 | |
| Ensemble | ENSG00000101844 | |
| UniProt | Q8WYN0 | |
| Refseq (mRNA) | NM_001321287.1 | |
| Refseq (protein) | NP_001308216.1 | |
| PubMed search |
115201
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Autophagin 4A is an enzyme from the group of cysteine proteases .
properties
Autophagin 4A is produced in many cell types , particularly in the skeletal muscles and the brain . It is involved in transport from the cytosol to vacuoles and in autophagy . Autophagin 4A cuts the C -terminal amino acid of autophagin 8 , which exposes a C -terminal glycine that binds phosphatidylethanolamine and subsequently to a lipid bilayer in the course of autophagy. The preferred substrate for autophagin 4A is GABARAPL2 , followed by MAP1LC3A and GABARAP . It is inhibited by N-ethyl maleimide. Autophagin 4A is redox- regulated; in a reducing environment it is activated, in an oxidizing environment it is inhibited.
Web links
Individual evidence
- ^ G. Mariño, JA Uría, XS Puente, V. Quesada, J. Bordallo, C. López-Otín: Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. In: The Journal of biological chemistry. Volume 278, Number 6, February 2003, pp. 3671-3678, doi : 10.1074 / jbc.M208247200 , PMID 12446702 .
- ↑ a b c d e f ATG4A - Cysteine protease ATG4A - Homo sapiens (human) - ATG4A gene & protein. In: uniprot.org. March 15, 2005, accessed February 12, 2019 .