Bax (protein)
| Bax (protein) | ||
|---|---|---|
|
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| Belt / surface model according to PDB 1F16 | ||
| Properties of human protein | ||
| Mass / length primary structure | 192 amino acids | |
| Secondary to quaternary structure | Homodimer; Heterodimer with BCL2, E1B19k, BCL2L1, MCL1, A1 | |
| Isoforms | α, β, γ, δ, ε, ζ, ψ, σ | |
| Identifier | ||
| Gene name | BAX | |
| External IDs | ||
| Occurrence | ||
| Homology family | BAX | |
| Parent taxon | Euteleostomi | |
Bax (Bcl-2-associated X protein) is a protein in vertebrates , which as a co-factor of the tumor suppressor protein p53 acts. The Bax gene belongs to the Bcl-2 gene family. Bax is induced by p53 and accelerates the initiation of apoptosis . Low Bax release correlates with a poor prognosis for oral cancer .
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- Toshiyuki Miyashita, John C. Reed: Tumor Suppressor p53 Is a Direct Transcriptional Activator of the Human bax Gene. In: Cell. Volume 80, 1995, pp. 293-299. PMID 7834749
- Z. Oltvai, C. Milliman, SJ Korsmeyer : Bcl-2 Heterodimerizes in vivo with a Conserved Homolog, Bax, that Accelerates Programmed Cell Death. In: Cell. Volume 74, 1993, pp. 609-619. PMID 8358790