Stanley J. Korsmeyer
Stanley Joel Korsmeyer (born June 8, 1950 in Beardstown , Illinois , † March 31, 2005 in Boston , Massachusetts ) was an American oncologist and cancer researcher .
Life
Korsmeyer earned a Bachelor in Biology at the University of Illinois at Urbana-Champaign and graduated in medicine at the University of Illinois in Chicago with the MD from. Korsmeyer completed his specialist training at the University of California Hospitals in San Francisco before working as a postdoctoral fellow with Philip Leder and Thomas Waldmann at the National Cancer Institute from 1979 to 1986 . Here he learned, among other things, the techniques for producing recombinant DNA and headed his own research group (senior investigator) .
At Washington University in St. Louis , Korsmeyer was made professor of internal medicine and head of the department of molecular oncology in 1986 .
In 1998, Korsmeyer went to the Dana-Farber Cancer Institute in Boston , where he led the molecular oncology program within the Cancer Immunology and AIDS Division. At the same time, he held professorships in pathology and internal medicine at Harvard Medical School . Since the mid-1980s, Korsmeyer had also conducted research for the Howard Hughes Medical Institute (HHMI).
Korsmeyer died of lung cancer as a non-smoker. He was married and had two sons.
Act
Korsmeyer and co-workers discovered that the protein Bcl-2 develops its oncogenic effect not by increasing cell division , but by inhibiting apoptosis (programmed cell death). He established the doctrine that susceptibility to cell death is a result of the competition between pro-apoptotic (such as Bcl-2 antagonist-of-cell-death and Bax ) and anti-apoptotic members of the Bcl-2 family. With elegant model experiments, he was able to clarify the significance of impaired cell death in cancer , immunodeficiency , autoimmune diseases , infertility and various degenerative diseases.
Awards (selection)
- 1993 Pasarow Award
- 1995 membership in the National Academy of Sciences
- 1998 Charles S. Mott Prize
- 2000 membership in the American Academy of Arts and Sciences
- 2000 Louisa Gross Horwitz Prize
- 2002 membership in the American Philosophical Society
- 2002 Wiley Prize in Biomedical Sciences
- 2003 George M. Kober Lectureship
The American Society for Clinical Investigation (ASCI) missed the 10,000 US dollars doped Stanley J. Korsmeyer Award . Korsmeyer was the first recipient of this award in 1998, which was called the ASCI Award until 2005 .
literature
- Craig Thompson: Obituary for Stanley J. Korsmeyer. In: Cell . Volume 121, Number 3, May 6, 2005, pp. 319-320, ISSN 0092-8674 . doi: 10.1016 / j.cell.2005.04.023 .
- HR Horvitz : Obituary: Stanley J. Korsmeyer (1950-2005). In: Nature . Volume 435, Number 7039, May 2005, p. 161, ISSN 1476-4687 . doi: 10.1038 / 435161a . PMID 15889078 .
- Timothy J. Ley: Retrospective: Stanley Joel Korsmeyer (1950-2005). In: Science. Volume 308, Number 5723, May 2005, pp. 803-804, ISSN 1095-9203 . doi: 10.1126 / science.1113842 . PMID 15879200 .
- L. Scorrano: Stanley J. Korsmeyer (1950-2005). In: Journal of bioenergetics and biomembranes. Volume 37, Number 3, June 2005, p. 109, ISSN 0145-479X . doi: 10.1007 / s10863-005-7599-8 . PMID 16167166 .
Web links
- Biography and research abstract at the Howard Hughes Medical Institute (hhmi.org); Retrieved November 24, 2011
- In memoriam Stanley J. Korsmeyer, renowned cancer biologist, 54 at Harvard University (harvard.edu); Retrieved November 24, 2011
Individual evidence
- ↑ http://www.nasonline.org/member-directory/deceased-members/67729.html
- ↑ General Motors Cancer Research Awards Laureates 1979–1998 (PDF, 103 kB) at aacrjournals.org; Retrieved November 24, 2011
- ↑ Charles S. Mott Prize (1990-2002) ( Memento from March 14, 2007 in the Internet Archive ) at General Motors (gm.com)
- ↑ Book of Members (PDF, 612 kB) of the American Academy of Arts and Sciences (amacad.org); Retrieved November 24, 2011
- ^ Horwitz Prize Goes To MIT's Horvitz, Harvard's Korsmeyer at Columbia University (columbia.edu); Retrieved November 24, 2011
- ↑ Dr. Stanley J. Korsmeyer at the American Philosophical Society (amphilsoc.org); Retrieved February 4, 2016
- ^ Past winners of the Wiley Prize in Biomedical Sciences at wiley.com; Retrieved November 24, 2011
- ^ The Stanley J. Korsmeyer Award at the-asci.org; Retrieved November 24, 2011
personal data | |
---|---|
SURNAME | Korsmeyer, Stanley J. |
ALTERNATIVE NAMES | Korsmeyer, Stanley; Korsmeyer, Stanley Joel |
BRIEF DESCRIPTION | American cancer researcher |
DATE OF BIRTH | June 8, 1950 |
PLACE OF BIRTH | Beardstown , Illinois |
DATE OF DEATH | March 31, 2005 |
Place of death | Boston , Massachusetts |