Bcl-2 antagonist-of-cell-death
| BCL2 antagonist of cell death | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 168 aa; 18.4 kDa | |
| Secondary to quaternary structure | Heterodimer | |
| Identifier | ||
| Gene names | BAD ; BBC2; BCL2L8 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Eutheria ( higher mammals ) | |
| Orthologue | ||
| human | mouse | |
| Entrez | 572 | 12015 |
| Ensemble | ENSG00000002330 | ENSMUSG00000024959 |
| UniProt | Q92934 | Q3TFU7 |
| Refseq (mRNA) | NM_004322 | NM_007522 |
| Refseq (protein) | NP_004313 | NP_031548 |
| Gene locus | Chr 11: 63.79 - 63.81 Mb | Chr 19: 7.01 - 7.02 Mb |
| PubMed search | 572 |
12015
|
Bcl-2 antagonist of cell death (BAD) is a pro-apoptotic protein of the Bcl-2 family.
It works by binding and deactivating an apoptosis-inhibiting protein. When BAD is phosphorylated by protein kinase B ( initiated in a signaling pathway by PI 3 kinase ), it can no longer bind the apoptosis-inhibiting protein.
See also
swell
- ↑ Yang et al .: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995; 80 (2): 285-91. PMID 7834748