Bcl-2
| Bcl-2 | ||
|---|---|---|
|
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| Structure according to PDB 1G5M | ||
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Existing structural data: 1g5m, 2o2f |
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| Properties of human protein | ||
| Mass / length primary structure | 239 aa; 26.3 kDa | |
| Secondary to quaternary structure | Homodimer; Heterodimer | |
| Isoforms | Alpha, beta | |
| Identifier | ||
| Gene names | BCL-2 ; BCL2 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Euteleostomi | |
| Orthologue | ||
| human | mouse | |
| Entrez | 596 | 12043 |
| Ensemble | ENSG00000171791 | ENSMUSG00000057329 |
| UniProt | P10415 | Q4VBF6 |
| Refseq (mRNA) | NM_000633 | NM_009741 |
| Refseq (protein) | NP_000624 | NP_033871 |
| Gene locus | Chr 18: 58.94 - 59.14 Mb | Chr 1: 108.37 - 108.54 Mb |
| PubMed search | 596 |
12043
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Bcl-2 (abbreviation for B-cell lymphoma 2 ) is a protein and the prototype of the protein family of the same name, which play a role in the regulation of programmed cell death ( apoptosis ). Some members of the family encourage apoptosis while others prevent it. It is believed that at least some of these proteins perform their function by regulating the release of cytochrome c from the mitochondrion by destabilizing or stabilizing the outer mitochondrial membrane. The destabilization of the outer mitochondrial membrane has a proapoptotic effect through the transfer of cytochrome c into the cell cytoplasm, the stabilization of the outer mitochondrial membrane an antiapoptotic effect. In addition, some of these proteins are likely to be involved in activating the procaspases .
Since the correct initiation of apoptosis is very important, a mutation in the genes of these proteins can have serious consequences. This is why this family of proteins is also considered a human proto- oncogene .
Overactivation leads to tissue proliferation and thus to tumors . The protein was first in B cells - Lymphoma isolated (BCL).
| Bcl-2 family proteins | |
|---|---|
| Anti-apoptotic effect |
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| Pro-apoptotic effect | |
Bcl-2 inhibitors such as venetoclax are used in the therapy of B-cell lymphomas .
Individual evidence
- ↑ Chao, DT & Korsmeyer, SJ (1998): BCL-2 family: regulators of cell death. In: Annu. Rev. Immunol. Vol. 16, pp. 395-419. PMID 9597135