Bernd Meyer (chemist)

Bernd Meyer

Bernd Meyer (born March 16, 1952 ) is a German chemist . Until September 2017 he was a professor for organic chemistry at the University of Hamburg . His main research interests were the structures of carbohydrates and their interactions with proteins in biological systems.

Life and career

Bernd Meyer studied chemistry at the University of Hamburg and received his doctorate there in 1979 with a dissertation on syntheses of deoxy disaccharides and the structure elucidation of carbohydrate-containing antibiotics . From 1979 to 1980 he was a post-doctoral student at the Technical University of Denmark in Lyngby , where he worked on enzyme reactions and the calculation of the 3D structure of oligosaccharides. From 1980 to 1988 he was a university assistant at the Carl von Ossietzky University of Oldenburg , where he completed his habilitation in 1986 and was appointed university lecturer. In 1988 he went to the Complex Carbohydrate Research Center (CCRC) at the University of Georgia in Athens, where he became an Associate Professor with tenure . From October 1993 until his retirement at the end of September 2017, he was Professor of Organic Chemistry at the University of Hamburg.

In 2018 he founded the company nextgray with partners, which develops and uses digital intelligence (AI) methods to solve scientific and technical problems.

Research priorities

Characterization of ligand-receptor interactions using saturation-transfer-difference NMR spectroscopy (STD NMR) and calculations of molecular dynamics
Analysis of the structures of glycoconjugates using NMR spectroscopy and mass spectrometry
Design and synthesis of inhibitors of glycosyltransferases

Essential research results

Development of the STD NMR process (Saturation Transfer Difference NMR)
Characterization of spectra of complex glycans with the help of artificial neural networks (ANN)
Design of specific inhibitors for glycosyltransferases
Characterization of post-translational modifications of glycoproteins with rapid methods for the analysis of pathophysiological relationships

Honor and research associations

Belfort Lecturer, Purdue University, 1996.
Deputy speaker of the Collaborative Research Center 470: Glycostructures in Biosystems, 1997–2006.
Speaker of the Graduate College 464: Glycostructures: Presentation Analysis, Structure and Function, 1999–2005.
Member of the Advisory Council to the Interdisciplinary Research Center in Biomedicine, IRB, Barcelona (2007-2013)

Selected patents

J. Thomsen, J. Sellers and B. Meyer, Apparatus and Methods for Identification of Materials Using Neural Networks, US Pat. US5218529
T. Peters, B. Meyer, Method for the detection of biologically active substances in substance libraries. Ger. Pat. No. DE19649359, Swiss Pat. 690695, UK Pat. GB23211401, US Pat. US6214561.

Individual evidence

↑ Moriz Mayer, Bernd Meyer: Characterization of ligand binding by saturation transfer difference NMR spectroscopy . In: Angewandte Chemie . tape 111 , 1999, pp. 1902-1906 , doi : 10.1002 / (SICI) 1521-3773 (19990614) 38:12 <1784 :: AID-ANIE1784> 3.0.CO; 2-Q .
↑ Moriz Mayer, Bernd Meyer: Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor. In: Journal of the American Chemical Society . tape 123 , no. 25 , June 2001, p. 6108–6117 , doi : 10.1021 / ja0100120 .
↑ Bernd Meyer, Torben Hansen, Donald Nute, Peter Albersheim, Alan Darvill, William York, Jeffery Sellers: Identification of the 1H-NMR spectra of complex oligosaccharides with artificial neural networks . In: Science . tape 251 , no. 4993 , 1991, pp. 542-544 , doi : 10.1126 / science.1990429 .
↑ Jan P. Radomski, Herman van Halbeek, Bernd Meyer: Neural network-based recognition of oligosaccharide 1-H-NMR spectra . In: Nature Structural Biologyvolume . tape 1 , 1994, p. 217-218 , doi : 10.1038 / nsb0494-217 .
↑ Miriam P. Kötzler, Simon Blank, Frank I. Bantleon, Martin Wienke, Edzard Spillner, and Bernd Meyer: Donor Assists Acceptor Binding and Catalysis of Human α1,6-Fucosyltransferase . In: ACS Chemical Biology . tape 8 , no. 8 , 2013, p. 1830-1840 , doi : 10.1021 / cb400140u .
↑ Tim Nagel, Florentine Klaus, Ines Gil Ibanez, Henning Weg, Ansgar Lohse, Bernd Meyer: Fast and facile analysis of glycosylation and phosphorylation of fibrinogen from human plasma — correlation with liver cancer and liver cirrhosis . In: Analytical and Bioanalytical Chemistry . tape 410 , no. 30 , 2018, p. 7965-7977 , doi : 10.1007 / s00216-018-1418-7 .

personal data
SURNAME	Meyer, Bernd
BRIEF DESCRIPTION	German chemist and university professor
DATE OF BIRTH	March 16, 1952

[1] Moriz Mayer, Bernd Meyer: Characterization of ligand binding by saturation transfer difference NMR spectroscopy . In: Angewandte Chemie . tape 111 , 1999, pp. 1902-1906 , doi : 10.1002 / (SICI) 1521-3773 (19990614) 38:12 <1784 :: AID-ANIE1784> 3.0.CO; 2-Q .

[2] Moriz Mayer, Bernd Meyer: Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor. In: Journal of the American Chemical Society . tape 123 , no. 25 , June 2001, p. 6108–6117 , doi : 10.1021 / ja0100120 .

[3] Bernd Meyer, Torben Hansen, Donald Nute, Peter Albersheim, Alan Darvill, William York, Jeffery Sellers: Identification of the 1H-NMR spectra of complex oligosaccharides with artificial neural networks . In: Science . tape 251 , no. 4993 , 1991, pp. 542-544 , doi : 10.1126 / science.1990429 .

[4] Jan P. Radomski, Herman van Halbeek, Bernd Meyer: Neural network-based recognition of oligosaccharide 1-H-NMR spectra . In: Nature Structural Biologyvolume . tape 1 , 1994, p. 217-218 , doi : 10.1038 / nsb0494-217 .

[5] Miriam P. Kötzler, Simon Blank, Frank I. Bantleon, Martin Wienke, Edzard Spillner, and Bernd Meyer: Donor Assists Acceptor Binding and Catalysis of Human α1,6-Fucosyltransferase . In: ACS Chemical Biology . tape 8 , no. 8 , 2013, p. 1830-1840 , doi : 10.1021 / cb400140u .

[6] Tim Nagel, Florentine Klaus, Ines Gil Ibanez, Henning Weg, Ansgar Lohse, Bernd Meyer: Fast and facile analysis of glycosylation and phosphorylation of fibrinogen from human plasma — correlation with liver cancer and liver cirrhosis . In: Analytical and Bioanalytical Chemistry . tape 410 , no. 30 , 2018, p. 7965-7977 , doi : 10.1007 / s00216-018-1418-7 .