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Brenne is the family name of the following people:
- Fritz Brenne (1901–2003), German tennis official
- Simen Brenne (* 1981), Norwegian football player
- Werner Brenne (1931-2010), German politician (SPD)
- Winfried Brenne (* 1942), architect and author
Brenne also stands for:
- Brenne (habitat) , a botanical habitat
- Brenne (electroplating) , a technique for pickling copper
- Brenne (Touraine) , part of the historic French province of Touraine
- Brenne Regional Natural Park , natural park in the Indre department, France
- Brenne (Cisse) , a tributary of the Cisse, France
- Brenne (Armançon) , a tributary of the Armançon, France
- Brenne (Seille) , a tributary of the Seille, France