Arne Skerra

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Arne Skerra (born July 30, 1961 in Wiesbaden ) is a German biochemist and full professor at the Technical University of Munich .

Life

After studying chemistry at the TH Darmstadt , he received his doctorate at the gene center of the Ludwig Maximilians University in Munich under Andreas Plückthun . He later became a postdoctoral fellow in Cambridge, England and group leader at the Max Planck Institute for Biophysics with Nobel Prize winner Hartmut Michel . After his habilitation at the Johann Wolfgang Goethe University in Frankfurt am Main and a professorship in Darmstadt, he became professor for biological chemistry at the Technical University of Munich.

Act

Skerra conducts research in the field of molecular biotechnology in the field of protein engineering . On the one hand it is about the development of functionally tailor-made artificial proteins , on the other hand it is about the functional and structural analysis of biologically relevant natural proteins, for example using crystallographic methods.

List of current and former research priorities:

  • Strep -Tag technology: Development of an affinity tag that binds to streptavidin and Strep -Tactin and is used in affinity chromatography.
  • Anticalin technology: Development of binding proteins based on human lipocalins .
  • Crystallographic elucidation of the protein class of the lipocalins .
  • PASylation technology: Development of polymers made from proline, alanine and serine which, after genetic fusion to a therapeutic protein, extend its plasma half-life.

Awards

He is the holder of the Heinz Maier-Leibnitz Medal of the Technical University and - himself a former scholarship holder - Liaison Lecturer of the German National Academic Foundation at the Technical University of Munich. For the development of the anticalins , a new class of receptor proteins with antibody-like properties, Skerra was nominated for the German Future Prize in 2004 and was awarded the Karl Heinz Beckurts Prize in 2005. In 2008 Skerra was elected to acatech .

Individual evidence

  1. ^ TG Schmidt, J. Koepke, R. Frank, A. Skerra: Molecular interaction between the Strep-tag affinity peptide and its cognate target, streptavidin. In: Journal of molecular biology. Volume 255, Number 5, February 1996, pp. 753-766, doi: 10.1006 / jmbi.1996.0061 , PMID 8636976 .
  2. ↑ Homepage of Pieris AG
  3. ↑ A. Schiefner, A. Skerra: The menagerie of human lipocalins: a natural protein scaffold for molecular recognition of physiological compounds. In: Accounts of chemical research. Volume 48, Number 4, April 2015, pp. 976-985, doi: 10.1021 / ar5003973 , PMID 25756749 (review).
  4. ↑ M. Schlapschy, U. Binder, C. Börger, I. Theobald, K. Wachinger, S. Kisling, D. Haller, A. Skerra: PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins. In: Protein engineering, design & selection: PEDS. Volume 26, Number 8, August 2013, pp. 489-501, doi: 10.1093 / protein / gzt023 , PMID 23754528 , PMC 3715784 (free full text).
  5. ↑ Homepage of XL-protein GmbH
  6. ↑ Nominees 2004. In: deutscher-zukunftspreis.de. Retrieved February 15, 2017 .
  7. ↑ Karl Heinz Beckurts Prize for biochemist Arne Skerra - press release by the Science Information Service dated December 9, 2005

Web links

personal data
SURNAME Skerra, Arne
BRIEF DESCRIPTION German biochemist
DATE OF BIRTH July 30, 1961
PLACE OF BIRTH Wiesbaden