c-Fos

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FOS
FOS
according to PDB  1A02
other names
  • FBJ Murine Osteosarcoma Viral Oncogene Homolog
  • G0 / G1 Switch Regulatory Protein 7
  • Cellular Oncogene C-Fos
  • G0S7
  • P55

Existing structural data : 1A02 , 1FOS , 1S9K

Properties of human protein
Mass / length primary structure 380 amino acids, 40695 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 2353 14281
UniProt P01100 P01101
PubMed search 2353 14281

c-FOS is a component of the transcription factor AP-1 and a proto-oncogene .

properties

FosB , Fra-1 and Fra-2 as well as the smaller FosB splice variants FosB2 and ΔFosB also belong to the same Fos protein family . The gene belongs to the immediate early genes . The protein c-Fos binds to BCL3 , COBRA1 , CSNK2A1 , CSNK2A2 , DDIT3 , c-Jun NCOA1 , NCOR2 , RELA , RUNX1 , RUNX2 , SMAD3 and TBP .

Overview of signal transduction pathways involved in apoptosis.

Mutations in the c-Fos gene occur in various tumors . The homolog of the c-Fos from retroviruses is called v-Fos (viral Fos).

Individual evidence

  1. ↑ Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M: The c-Fos protein interacts with c-Jun / AP-1 to stimulate transcription of AP-1 responsive genes . In: Cell . 54, No. 4, August 1988, pp. 541-52. doi : 10.1016 / 0092-8674 (88) 90076-1 . PMID 3135940 .
  2. ^ Milde-Langosch K: The Fos family of transcription factors and their role in tumourigenesis . In: European Journal of Cancer . 41, No. 16, November 2005, pp. 2449-61. doi : 10.1016 / j.ejca.2005.08.008 . PMID 16199154 .
  3. ↑ Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW: Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation . In: J. Biol. Chem. . 274, No. 40, October 1999, pp. 28491-6. doi : 10.1074 / jbc.274.40.28491 . PMID 10497212 .
  4. ↑ Zhong H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Q: COBRA1 inhibits AP-1 transcriptional activity in transfected cells . In: Biochem. Biophys. Res. Commun. . 325, No. 2, December 2004, pp. 568-73. doi : 10.1016 / j.bbrc.2004.10.079 . PMID 15530430 .
  5. ↑ a b Yamaguchi Y, Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H: Casein kinase II interacts with the bZIP domains of several transcription factors . In: Nucleic Acids Res . 26, No. 16, August 1998, pp. 3854-61. doi : 10.1093 / nar / 26.16.3854 . PMID 9685505 . PMC 147779 (free full text).
  6. ↑ Ubeda M, Vallejo M, habener JF: CHOP enhancement of gene transcription by interactions with Jun / Fos AP-1 complex proteins . In: Mol. Cell. Biol . 19, No. 11, November 1999, pp. 7589-99. PMID 10523647 . PMC 84780 (free full text).
  7. ↑ a b Yang X, Chen Y, Gabuzda D: ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB . In: J. Biol. Chem. . 274, No. 39, September 1999, pp. 27981-8. doi : 10.1074 / jbc.274.39.27981 . PMID 10488148 .
  8. ↑ Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H: Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos / Jun dimers . In: J. Biol. Chem. . 276, No. 4, January 2001, pp. 2852-7. doi : 10.1074 / jbc.M009633200 . PMID 11053448 .
  9. ↑ Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H: Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity . In: Oncogene . 14, No. 17, May 1997, pp. 2091-8. doi : 10.1038 / sj.onc.1201046 . PMID 9160889 .
  10. ↑ Glover JN, Harrison SC: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA . In: Nature . 373, No. 6511, January 1995, pp. 257-61. doi : 10.1038 / 373257a0 . PMID 7816143 .
  11. ↑ Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S: Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 . In: J. Biol. Chem. . 268, No. 6, February 1993, pp. 4259-66. PMID 8440710 .
  12. ↑ Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF: Detection and modulation in vivo of helix-loop-helix protein-protein interactions . In: J. Biol. Chem. . 268, No. 1, January 1993, pp. 5-8. PMID 8380166 .
  13. ↑ Venugopal R, Jaiswal AK: Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes . In: Oncogene . 17, No. 24, December 1998, pp. 3145-56. doi : 10.1038 / sj.onc.1202237 . PMID 9872330 .
  14. ↑ Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW: Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer- amplified transcription coactivator ASC-2 . In: Mol. Endocrinol. . 14, No. 6, June 2000, pp. 915-25. doi : 10.1210 / mend.14.6.0471 . PMID 10847592 .
  15. ↑ Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW: Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits . In: J. Biol. Chem. . 273, No. 27, July 1998, pp. 16651-4. doi : 10.1074 / jbc.273.27.16651 . PMID 9642216 .
  16. ↑ Lee SK, Kim JH, Lee YC, Cheong J, Lee JW: Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor . In: J. Biol. Chem. . 275, No. 17, April 2000, pp. 12470-4. doi : 10.1074 / jbc.275.17.12470 . PMID 10777532 .
  17. ↑ a b Hess J, Porte D, Munz C, Angel P: AP-1 and Cbfa / runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2 / AP-1 composite element . In: J. Biol. Chem. . 276, No. 23, June 2001, pp. 20029-38. doi : 10.1074 / jbc.M010601200 . PMID 11274169 .
  18. ↑ a b D'Alonzo RC, Selvamurugan N, Karsenty G, Partridge NC: Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation . In: J. Biol. Chem. . 277, No. 1, January 2002, pp. 816-22. doi : 10.1074 / jbc.M107082200 . PMID 11641401 .
  19. ↑ Zhang Y, Feng XH, Derynck R: Smad3 and Smad4 cooperate with c-Jun / c-Fos to mediate TGF-beta-induced transcription . In: Nature . 394, No. 6696, August 1998, pp. 909-13. doi : 10.1038 / 29814 . PMID 9732876 .
  20. ↑ Metz R, Bannister AJ, Sutherland JA, Hagemeier C, O'Rourke EC, Cook A, Bravo R, Kouzarides T: c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein . In: Mol. Cell. Biol . 14, No. 9, September 1994, pp. 6021-9. doi : 10.1128 / MCB.14.9.6021 . PMID 8065335 . PMC 359128 (free full text).