c-Jun

from Wikipedia, the free encyclopedia
JUN
JUN
according to PDB  1A02
other names
  • Jun proto-oncogenes
  • V-Jun Avian Sarcoma Virus 17 Oncogene Homolog
  • P39
  • Jun Activation Domain Binding Protein

Existing structure data : 1A02 , 1FOS , 1JNM , 1JUN , 1S9K , 1T2K

Properties of human protein
Mass / length primary structure 331 amino acids, 35676 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 3725 16476
UniProt P05412 P05627
PubMed search 3725 16476

c-Jun is a component of the transcription factor AP-1 and a proto-oncogene .

properties

c-Jun is involved in the cell cycle and apoptosis . Mutations in the gene of c-Jun occur in various tumors . c-Jun was the first oncogenic transcription factor described. The homolog of the c-Jun ( English cellular Jun ) from retroviruses is called v-Jun ( English viral Jun ).

Interactions

c-Jun interacts with different proteins:

Individual evidence

  1. ↑ Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M: The c-Fos protein interacts with c-Jun / AP-1 to stimulate transcription of AP-1 responsive genes . In: Cell . 54, No. 4, August 1988, pp. 541-52. doi : 10.1016 / 0092-8674 (88) 90076-1 . PMID 3135940 .
  2. ↑ Vogt PK: Fortuitous convergences: the beginnings of JUN . In: Nature Reviews Cancer . 2, No. 6, June 2002, pp. 465-9. doi : 10.1038 / nrc818 . PMID 12189388 .
  3. ^ Wisdom R, Johnson RS, Moore C: c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms . In: The EMBO Journal . 18, No. 1, January 1999, pp. 188-97. doi : 10.1093 / emboj / 18.1.188 . PMID 9878062 . PMC 1171114 (free full text).
  4. ↑ M. Pessah, C. Prunier, J. Marais, N. Ferrand, A. Mazars, F. Lallemand, JM Gauthier, A. Atfi: c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity. In: Proceedings of the National Academy of Sciences . Volume 98, number 11, May 2001, pp. 6198-6203, doi: 10.1073 / pnas.101579798 , PMID 11371641 , PMC 33445 (free full text).
  5. ↑ A. Verger, E. Buisine, p Carrère, R. Wintjens, A. Flourens, J. Coll, D. STEHELIN, M. Duterque-Coquillaud: Identification of amino acid residues in the ETS transcription factor ERG Erg did mediate Jun / Fos-DNA ternary complex formation. In: The Journal of biological chemistry. Volume 276, Number 20, May 2001, pp. 17181-17189, doi: 10.1074 / jbc.M010208200 , PMID 11278640 .
  6. ↑ J. Nishitani, T. Nishinaka, CH Cheng, W. Rong, KK Yokoyama, R. Chiu: Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site. In: The Journal of biological chemistry. Volume 274, Number 9, February 1999, pp. 5454-5461, PMID 10026157 .
  7. ↑ Y. Sano, F. Tokitou, P. Dai, T. Maekawa, T. Yamamoto, S. Ishii: CBP alleviates the intramolecular inhibition of ATF-2 function. In: The Journal of biological chemistry. Volume 273, Number 44, October 1998, pp. 29098-29105, PMID 9786917 .
  8. ^ CL Newell, AB Deisseroth, G. Lopez-Berestein: Interaction of nuclear proteins with an AP-1 / CRE-like promoter sequence in the human TNF-alpha gene. In: Journal of leukocyte biology. Volume 56, Number 1, July 1994, pp. 27-35, PMID 8027667 .
  9. ↑ CJ Kara, HC Liou, LB Ivashkiv, LH Glimcher: A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain. In: Molecular and cellular biology. Volume 10, Number 4, April 1990, pp. 1347-1357, PMID 2320002 , PMC 362236 (free full text).
  10. ↑ a b T. Hai, T. Curran: Cross-family dimerization of transcription factors Fos / Jun and ATF / CREB alters DNA binding specificity. In: Proceedings of the National Academy of Sciences . Volume 88, Number 9, May 1991, pp. 3720-3724, PMID 1827203 , PMC 51524 (free full text).
  11. ↑ H. Zhong, J. Zhu, H. Zhang, L. Ding, Y. Sun, C. Huang, Q. Ye: COBRA1 inhibits AP-1 transcriptional activity in transfected cells. In: Biochemical and biophysical research communications. Volume 325, Number 2, December 2004, pp. 568-573, doi: 10.1016 / j.bbrc.2004.10.079 , PMID 15530430 .
  12. ↑ YF Hu, R. Li: JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction. In: Genes & development. Volume 16, number 12, June 2002, pp. 1509-1517, doi: 10.1101 / gad.995502 , PMID 12080089 , PMC 186344 (free full text).
  13. ↑ T. Ito, M. Yamauchi, M. Nishina, N. Yamamichi, T. Mizutani, M. Ui, M. Murakami, H. Iba: Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos / Jun dimers. In: The Journal of biological chemistry. Volume 276, Number 4, January 2001, pp. 2852-2857, doi: 10.1074 / jbc.M009633200 , PMID 11053448 .
  14. ↑ a b P. Pognonec, KE Boulukos, C. Aperlo, M. Fujimoto, H. Ariga, A. Nomoto, H. Kato: Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity . In: Oncogene. Volume 14, Number 17, May 1997, pp. 2091-2098, doi: 10.1038 / sj.onc.1201046 , PMID 9160889 .
  15. ↑ JN Glover, SC Harrison: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. In: Nature. Volume 373, Number 6511, January 1995, pp. 257-261, doi: 10.1038 / 373257a0 , PMID 7816143 .
  16. ↑ a b X. Yang, Y. Chen, D. Gabuzda: ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB. In: The Journal of biological chemistry. Volume 274, Number 39, September 1999, pp. 27981-27988, PMID 10488148 .
  17. ↑ N. Nomura, YL Zu, T. Maekawa, S. Tabata, T. Akiyama, S. Ishii: Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. In: The Journal of biological chemistry. Volume 268, Number 6, February 1993, pp. 4259-4266, PMID 8440710 .
  18. ↑ T. Finkel, J. Duc, ER Fearon, CV Dang, GF Tomaselli: Detection and modulation in vivo of helix-loop-helix protein-protein interactions. In: The Journal of biological chemistry. Volume 268, Number 1, January 1993, pp. 5-8, PMID 8380166 .
  19. ↑ a b c R. Venugopal, AK Jaiswal: Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. In: Oncogene. Volume 17, Number 24, December 1998, pp. 3145-3156, doi: 10.1038 / sj.onc.1202237 , PMID 9872330 .
  20. ^ J. Westermarck, C. Weiss, R. Saffrich, J. Kast, AM Musti, M. Wessely, W. Ansorge, B. Séraphin, M. Wilm, BC Valdez, D. Bohmann: The DEXD / H-box RNA helicase RHII / Gu is a co-factor for c-Jun-activated transcription. In: The EMBO journal. Volume 21, Number 3, February 2002, pp. 451-460, PMID 11823437 , PMC 125820 (free full text).
  21. ^ A b C. C. Franklin, AV McCulloch, AS Kraft: In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB. In: The Biochemical journal. Volume 305 (Pt 3), February 1995, pp. 967-974, PMID 7848298 , PMC 1136352 (free full text).
  22. ↑ T. Ishitani, G. Takaesu, J. Ninomiya-Tsuji, H. Shibuya, RB Gaynor, K. Matsumoto: Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. In: The EMBO journal. Volume 22, number 23, December 2003, pp. 6277-6288, doi: 10.1093 / emboj / cdg605 , PMID 14633987 , PMC 291846 (free full text).
  23. ↑ H. Nishitoh, M. Saitoh, Y. Mochida, K. Takeda, H. Nakano, M. Rothe, K. Miyazono, H. Ichijo: ASK1 is essential for JNK / SAPK activation by TRAF2. In: Molecular cell. Volume 2, Number 3, September 1998, pp. 389-395, PMID 9774977 .
  24. ↑ B. Dérijard, M. Hibi, IH Wu, T. Barrett, B. Su, T. Deng, M. Karin, RJ Davis: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c -Jun activation domain. In: Cell. Volume 76, Number 6, March 1994, pp. 1025-1037, PMID 8137421 .
  25. ^ O. Yazgan, CM Pfarr: Regulation of two JunD isoforms by Jun N-terminal kinases. In: The Journal of biological chemistry. Volume 277, Number 33, August 2002, pp. 29710-29718, doi: 10.1074 / jbc.M204552200 , PMID 12052834 .
  26. ↑ K. Tada, T. Okazaki, S. Sakon, T. Kobarai, K. Kurosawa, S. Yamaoka, H. Hashimoto, TW Mak, H. Yagita, K. Okumura, WC Yeh, H. Nakano: Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. In: The Journal of biological chemistry. Volume 276, Number 39, September 2001, pp. 36530-36534, doi: 10.1074 / jbc.M104837200 , PMID 11479302 .
  27. ↑ CF Meyer, X. Wang, C. Chang, D. Templeton, TH Tan: Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation. In: The Journal of biological chemistry. Volume 271, Number 15, April 1996, pp. 8971-8976, PMID 8621542 .
  28. ↑ E. Cano, CA Hazzalin, E. Kardalinou, RS Buckle, LC Mahadevan: Neither ERK nor JNK / SAPK MAP kinase subtypes are essential for histone H3 / HMG-14 phosphorylation or c-fos and c-jun induction. In: Journal of cell science. Volume 108 (Pt 11), November 1995, pp. 3599-3609, PMID 8586671 .
  29. ^ C. Tournier, AJ Whitmarsh, J. Cavanagh, T. Barrett, RJ Davis: Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. In: Proceedings of the National Academy of Sciences . Volume 94, Number 14, July 1997, pp. 7337-7342, PMID 9207092 , PMC 23822 (free full text).
  30. ↑ SK Lee, JH Kim, YC Lee, J. Cheong, JW Lee: Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. In: The Journal of biological chemistry. Volume 275, Number 17, April 2000, pp. 12470-12474, PMID 10777532 .
  31. ↑ SK Lee, JH Kim, YC Lee, J. Cheong, JW Lee: Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. In: The Journal of biological chemistry. Volume 275, Number 17, April 2000, pp. 12470-12474, PMID 10777532 .
  32. ^ E. Bianchi, S. Denti, R. Catena, G. Rossetti, S. Polo, S. Gasparian, S. Putignano, L. Rogge, R. Pardi: Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity. In: The Journal of biological chemistry. Volume 278, Number 22, May 2003, pp. 19682-19690, doi: 10.1074 / jbc.M212681200 , PMID 12615916 .
  33. ↑ GM Wulf, A. Ryo, GG Wulf, SW Lee, T. Niu, V. Petkova, KP Lu: Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. In: The EMBO journal. Volume 20, number 13, July 2001, pp. 3459-3472, doi: 10.1093 / emboj / 20.13.3459 , PMID 11432833 , PMC 125530 (free full text).
  34. ^ Y. Zhang, XH Feng, R. Derynck: Smad3 and Smad4 cooperate with c-Jun / c-Fos to mediate TGF-beta-induced transcription. In: Nature. Volume 394, Number 6696, August 1998, pp. 909-913, doi: 10.1038 / 29814 , PMID 9732876 .
  35. ↑ F. Verrecchia, M. Pessah, A. Atfi, A. Mauviel: Tumor necrosis factor-alpha inhibits transforming growth factor-beta / Smad signaling in human dermal fibroblasts via AP-1 activation. In: The Journal of biological chemistry. Volume 275, Number 39, September 2000, pp. 30226-30231, doi: 10.1074 / jbc.M005310200 , PMID 10903323 .
  36. ^ NT Liberati, MB Datto, JP Frederick, X. Shen, C. Wong, EM Rougier-Chapman, XF Wang: Smads bind directly to the Jun family of AP-1 transcription factors. In: Proceedings of the National Academy of Sciences . Volume 96, Number 9, April 1999, pp. 4844-4849, PMID 10220381 , PMC 21779 (free full text).
  37. ↑ DJ Jung, HS Sung, YW Goo, HM Lee, OK Park, SY Jung, J. Lim, HJ Kim, SK Lee, TS Kim, JW Lee, YC Lee: Novel transcription coactivator complex containing activating signal cointegrator 1. In: Molecular and cellular biology. Volume 22, Number 14, July 2002, pp. 5203-5211, PMID 12077347 , PMC 139772 (free full text).
  38. ^ A b Y. Yamaguchi, T. Wada, F. Suzuki, T. Takagi, J. Hasegawa, H. Handa: Casein kinase II interacts with the bZIP domains of several transcription factors. In: Nucleic acids research. Volume 26, Number 16, August 1998, pp. 3854-3861, PMID 9685505 , PMC 147779 (free full text).
  39. ^ A b X. Zhang, MH Wrzeszczynska, CM Horvath, JE Darnell: Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. In: Molecular and cellular biology. Volume 19, Number 10, October 1999, pp. 7138-7146, PMID 10490649 , PMC 84707 (free full text).
  40. ↑ FH Vasanwala, S. Kusam, LM Toney, AL Dent: Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. In: Journal of Immunology (Baltimore, Md.: 1950). Volume 169, Number 4, August 2002, pp. 1922-1929, PMID 12165517 .
  41. ^ SY Na, JE Choi, HJ Kim, BH Jhun, YC Lee, JW Lee: Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation. In: The Journal of biological chemistry. Volume 274, Number 40, October 1999, pp. 28491-28496, PMID 10497212 .
  42. ↑ N. Sato, MD Sadar, N. Bruchovsky, F. Saatcioglu, PS Rennie, S. Sato, PH Lange, ME Gleave: Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP -1 / c-Jun in the human prostate cancer cell line LNCaP. In: The Journal of biological chemistry. Volume 272, Number 28, July 1997, pp. 17485-17494, PMID 9211894 .
  43. ↑ JP Basuyaux, E. Ferreira, D. Stéhelin, G. Butticè: The Ets transcription factors interact with each other and with the c-Fos / c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner. In: The Journal of biological chemistry. Volume 272, Number 42, October 1997, pp. 26188-26195, PMID 9334186 .
  44. ^ AG Pearson, CW Gray, JF Pearson, JM Greenwood, MJ During, M. Dragunow: ATF3 enhances c-Jun-mediated neurite sprouting. In: Brain research. Molecular brain research. Volume 120, Number 1, December 2003, pp. 38-45, PMID 14667575 .
  45. ^ BP Chen, CD Wolfgang, T. Hai: Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153 / Chop10. In: Molecular and cellular biology. Volume 16, Number 3, March 1996, pp. 1157-1168, PMID 8622660 , PMC 231098 (free full text).
  46. ^ A. Moreau, WV Yotov, FH Glorieux, R. St-Arnaud: Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription. In: Molecular and cellular biology. Volume 18, Number 3, March 1998, pp. 1312-1321, PMID 9488446 , PMC 108844 (free full text).
  47. ^ FX Claret, M. Hibi, S. Dhut, T. Toda, M. Karin: A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. In: Nature. Volume 383, Number 6599, October 1996, pp. 453-457, doi: 10.1038 / 383453a0 , PMID 8837781 .
  48. ↑ M. Ubeda, M. Vallejo, JF habener: CHOP enhancement of gene transcription by interactions with Jun / Fos AP-1 complex proteins. In: Molecular and cellular biology. Volume 19, Number 11, November 1999, pp. 7589-7599, PMID 10523647 , PMC 84780 (free full text).
  49. ↑ DJ Jung, SY Na, DS Na, JW Lee: Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. In: The Journal of biological chemistry. Volume 277, Number 2, January 2002, pp. 1229-1234, doi: 10.1074 / jbc.M110417200 , PMID 11704680 .
  50. ↑ SK Lee, SL Anzick, JE Choi, L. Bubendorf, XY Guan, YK Jung, OP Kallioniemi, J. Kononen, JM Trent, D. Azorsa, BH Jhun, JH Cheong, YC Lee, PS Meltzer, JW Lee: A. nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. In: The Journal of biological chemistry. Volume 274, Number 48, November 1999, pp. 34283-34293, PMID 10567404 .
  51. ↑ SK Lee, SY Na, SY Jung, JE Choi, BH Jhun, J. Cheong, PS Meltzer, YC Lee, JW Lee: Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer -amplified transcription coactivator ASC-2. In: Molecular endocrinology (Baltimore, Md.). Volume 14, Number 6, June 2000, pp. 915-925, doi: 10.1210 / mend.14.6.0471 , PMID 10847592 .
  52. ↑ SK Lee, HJ Kim, SY Na, TS Kim, HS Choi, SY Im, JW Lee: Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits. In: The Journal of biological chemistry. Volume 273, Number 27, July 1998, pp. 16651-16654, PMID 9642216 .
  53. ^ E. Bengal, L. Ransone, R. Scharfmann, VJ Dwarki, SJ Tapscott, H. Weintraub, IM Verma: Functional antagonism between c-Jun and MyoD proteins: a direct physical association. In: Cell. Volume 68, Number 3, February 1992, pp. 507-519, PMID 1310896 .
  54. ↑ a b J. Hess, D. Porte, C. Munz, P. Angel: AP-1 and Cbfa / runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2 / AP-1 composite element. In: The Journal of biological chemistry. Volume 276, Number 23, June 2001, pp. 20029-20038, doi: 10.1074 / jbc.M010601200 , PMID 11274169 .
  55. ↑ a b R. C. D'Alonzo, N. Selvamurugan, G. Karsenty, NC Partridge: Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. In: The Journal of biological chemistry. Volume 277, Number 1, January 2002, pp. 816-822, doi: 10.1074 / jbc.M107082200 , PMID 11641401 .