CCL14

from Wikipedia, the free encyclopedia
CCL14
other names
  • Chemokine (CC Motif) ligand 14
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 14
  • Chemokines CC-1 / CC-3
  • HCC-1 (1-74)
  • Hemofiltrate CC Chemokine 1

Existing structural data : 2Q8R , 2Q8T

Properties of human protein
Mass / length primary structure 93 amino acids, 10,678 Da (isoform 1)

109 amino acids, 12,297 Da (isoform 2)

Isoforms 2
Identifier
Gene names CCL14 SCYA14, NCC2, HCC-3, CKB1, MCIF, SY14
External IDs
Orthologue (human)
Entrez 6358
Ensemble ENSG00000276409
UniProt Q16627
Refseq (mRNA) NM_032962
Refseq (protein) NP_116738
Gene locus Chr 17: 35.98 - 35.99 Mb
PubMed search 6358

CCL14 ( English CC chemokine ligand 14 , synonym HCC-1 ) is a cytokine from the family of CC chemokines .

properties

CCL14 is a preprotein and is cleaved into an active form of 76 amino acids. The active form is involved in inflammatory processes. CCL14 has a high degree of homology to CCL3 and CCL4 . It activates monocytes . CCL14 is produced in the spleen , bone marrow , liver , muscles and intestines .

Individual evidence

  1. ↑ Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.