CCR6

CC chemokine receptor type 6
other names	Chemokine receptor-like 3, CKR-L3
Properties of human protein
Mass / length primary structure	374 amino acids , 42,494 Da
Identifier
External IDs	GeneCards : CCR6 ; OMIM : 601835 ; UniProt : P51684 ;
	Orthologue (human)
Entrez	1235
Ensemble	ENSG00000112486
UniProt	P51684
Refseq (mRNA)	NM_004367.5
Refseq (protein)	NP_004358.2
PubMed search	1235

CC chemokine receptor type 6 (CCR6) is a surface protein from the group of chemokine receptors .

properties

CCR6 is a G-protein-coupled receptor and is mainly formed in the tail and in the postacrosomal region of spermatocytes . It binds CC-type chemokines , including CCL20 and beta-defensins ( DEFB1 ). It is used to regulate the mobility of the sperm and has antibacterial effects. CCR4 has disulfide bridges and is glycosylated . The binding of CCL20 to CCR6 mediates the chemotaxis of dendritic cells , T cells (including T _H17 cells and regulatory T cells ) and B cells , especially in the case of inflammation of the skin and mucous membranes and tissue damage. In the intestinal mucosa, it mediates the binding of T _H17 cells and B cells in Peyer's plaques and regulates inflammation in the intestine. There also conveys the class upgrade to immunoglobulin A . It is also involved in the development of thymocytes (including the precursor cells of the DN2 and DN3 types), but not of regulatory T cells in the thymus . In the spleen , it binds memory B cells . It also increases the mobility of sperm by binding CCL20.