CCL20

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CCL20
CCL20
according to PDB  1M8A
other names

Chemokine (CC Motif) ligand 20; SCYA20; MIP3A; LARC; Small Inducible Cytokine Subfamily A (Cys-Cys), member 20; Liver And Activation-Regulated Chemokine; Macrophage Inflammatory Protein 3 Alpha; Small-Inducible Cytokine A20; CC Chemokine LARC; MIP-3 alpha; Beta chemokine exodus-1; Beta chemokine Exodus-1; CC Motif Chemokine 20; Exodus; MIP-3a; CKb4; ST38

Existing structural data : 1M8A , 2HCI , 2JYO

Properties of human protein
Mass / length primary structure 96 amino acids, 10762 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 6364 20297
UniProt P78556 O89093
PubMed search 6364 20297

CCL20 ( English CC chemokine ligand 20 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL20 is involved in inflammatory processes. It is chemotactic for lymphocytes and, to a lesser extent, neutrophils . CCL20 binds to the CCR6 receptor . CCL20 is induced by lipopolysaccharides (LPS) or the cytokines TNF-alpha and interferon-γ and downregulated by IL-10 . CCL20 is produced by lymphocytes, in lymph nodes , in the liver , appendix , in the fetal lung and to a lesser extent in the thymus , testes and intestines .

Individual evidence

  1. ↑ a b Hieshima K, Imai T, Opdenakker G, Van Damme J, Kusuda J, Tei H, Sakaki Y, Takatsuki K, Miura R, Yoshie O, Nomiyama H: Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2 . In: J. Biol. Chem. . 272, No. 9, 1997, pp. 5846-5853. doi : 10.1074 / jbc.272.9.5846 . PMID 9038201 .
  2. ↑ Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, Nomiyama H, Yoshie O: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC . In: J. Biol. Chem. . 272, No. 23, 1997, pp. 14893-14898. doi : 10.1074 / jbc.272.23.14893 . PMID 9169459 .
  3. ↑ Schutyser E, Struyf S, Menten P, Lenaerts JP, Conings R, Put W, Wuyts A, Proost P, Van Damme J: Regulated production and molecular diversity of human liver and activation-regulated chemokine / macrophage inflammatory protein-3 alpha from normal and transformed cells . In: J. Immunol. . 165, No. 8, 2000, pp. 4470-7. doi : 10.4049 / jimmunol.165.8.4470 . PMID 11035086 .
  4. ↑ Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A: Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta . In: J. Immunol. . 158, No. 3, 1997, pp. 1033-6. PMID 9013939 .