COL19A1

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Collagen type XIX, alpha 1
other names
  • Alpha-1 type XIX collagen
  • Collagen Alpha-1 (XIX) chain
  • Collagen alpha-1 chain type XIX
  • Collagen Alpha-1 (Y) chain
Properties of human protein
Mass / length primary structure 1,142 amino acids , 115,221 Da
Identifier
Gene names COL19A1; D6S228E
External IDs
Occurrence
Parent taxon Amniota , Neopterygii
Orthologue
human House mouse
Entrez 1310 12823
Ensemble ENSG00000082293 ENSMUSG00000026141
UniProt Q14993 Q0VF58
Refseq (mRNA) NM_001858 NM_007733
Refseq (protein) NP_001849.2 NP_031759.2
Gene locus Chr 6: 69.87 - 70.21 Mb Chr 1: 24.26 - 24.59 Mb
PubMed search 1310 12823

Collagen type XIX, alpha 1 is a fibrillenassoziiertes collagen that the gene COL19A1 is encoded. It forms homotrimers , which in turn form collagen fibrils of type XIX.

properties

Collagen type XIX, alpha 1 acts as a cross-bridge between fibrils and other extracellular matrix molecules. It is mostly located in the vascular , neuronal , mesenchymal and epithelial basement membrane . In addition, collagen XIX is a determining factor for the function of the sphincter muscle and acts as an extrinsic factor for skeletal myogenesis in the esophagus of the house mouse . The NC2 domain is responsible for chain selection and its trimerization.

Web links

Individual evidence

  1. M. Khaleduzzaman, H. Sumiyoshi, Y. Ueki, K. Inoguchi, Y. Ninomiya, H. Yoshioka: Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family . In: Genomics . 45, No. 2, October 15, 1997, pp. 304-312. doi : 10.1006 / geno.1997.4921 . PMID 9344653 .
  2. Jump up Jeanne C. Myers, Deqin Li, Peter S. Amenta, Charles C. Clark, Chandrasekaran Nagaswami, John W. Weisel: Type XIX collagen purified from human umbilical cord is characterized by multiple sharp kinks delineating collagenous subdomains and by intermolecular aggregates via globular , disulfide-linked, and heparin-binding amino termini . In: J Biol Chem . 278, No. 34, August 22, 2003, pp. 32047-32057. doi : 10.1074 / jbc.M304629200 . PMID 12788917 .
  3. Hideaki Sumiyoshi, Niv Mor, Sui Y. Lee, Stephen Doty, Scott Henderson, Shizuko Tanaka, Hidekatsu Yoshioka, Satish Rattan, Francesco Ramirez: Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX – rich basement membrane zone . In: J Cell Biol . 166, No. 4, August 16, 2004, pp. 591-600. doi : 10.1083 / jcb.200402054 . PMID 15302855 . PMC 2172222 (free full text).
  4. Sergei P. Boudko, Jürgen Engel, Hans Peter Bächinger: Trimerization and Triple Helix Stabilization of the Collagen XIX NC2 Domain . In: J Biol Chem . 283, No. 49, December 5, 2008, pp. 34345-34351. doi : 10.1074 / jbc.M806352200 . PMID 18845531 . PMC 2662240 (free full text).