COL5A3
| Type V collagen, alpha 3 | ||
|---|---|---|
| other names |
|
|
| Properties of human protein | ||
| Mass / length primary structure | 172,121 daltons / 1,745 amino acids | |
| Identifier | ||
| Gene name | COL5A3 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Vertebrates | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 50509 | 53867 |
| Ensemble | ENSG00000080573 | ENSMUSG00000004098 |
| UniProt | P25940 | Q9JLI2 |
| Refseq (mRNA) | NM_015719 | NM_016919 |
| Refseq (protein) | NP_056534.2 | NP_001304317 |
| Gene locus | Chr 19: 9.96 - 10.01 Mb | Chr 9: 20.77 - 20.82 Mb |
| PubMed search | 50509 |
53867
|
Type V collagen, alpha 3 , also known as alpha-3 type V collagen , is a fibrillary collagen encoded by the COL5A3 gene in the human organism . It is an integral part of tissues and regulates the arrangement of heterotypic nerve fibers . Mutations in this gene are associated with Ehlers-Danlos syndrome , hypermobile type.
function
In the adipose tissue of the back fat of pigs, COL5A3 plays a role as a differentially expressed gene in adipogenesis .
In mice, the pro-α3 (V) chain co-localizes with heparan sulfate after an injury in the skin, with heparan sulfate binding to the chain via an acidic molecular unit of the pro-α3 (V) chain. Therefore, the extracellular matrix , which contains the pro-α3 (V) chain, might be needed to initiate wound healing in mice.
The degradation of COL5A3 by MMP9 ( English matrix metallopeptidase 9 ) could influence the susceptibility to eczema .
Individual evidence
- ↑ COL5A3. In: GeneCards (English).
- ↑ GeneID 50509
- ↑ Dajeong Lim, Kyung-Tai Lee, Jong Eun Park, Heebal Kim, Tae-Hun Kim, Bong-Hwan Choi, Myung Jick Kim, Hye-Sun Park, Gul-Won Jang: Analysis of gene expression profiles from subcutaneous adipose tissue of two pig breeds. In: Genes & Genomics. 33, 2011, p. 693, doi : 10.1007 / s13258-011-0083-4 .
- ↑ H. Sumiyoshi, H. Kitamura, N. Matsuo, S. Tatsukawa, K. Ishikawa, O. Okamoto, Y. Fujikura, S. Fujiwara, H. Yoshioka: Transient expression of mouse pro-α3 (V) collagen gene ( Col5a3) in wound healing. In: Connective tissue research. Volume 53, number 4, 2012, pp. 313-317, doi : 10.3109 / 03008207.2011.653061 , PMID 22214369 .
- ^ P. Margaritte-Jeannin, MC Babron, C. Laprise, N. Lavielle, C. Sarnowski, M. Brossard, M. Moffatt, V. Gagné-Ouellet, A. Etcheto, M. Lathrop, J. Just, WO Cookson , E. Bouzigon, F. Demenais, MH Dizier: The COL5A3 and MMP9 genes interact in eczema susceptibility. In: Clinical and Experimental Allergy. Volume 48, number 3, 03 2018, pp. 297-305, doi : 10.1111 / cea.13064 , PMID 29168291 .