Cefaclor

Structural formula
General
Non-proprietary name	Cefaclor
other names	(6 R , 7 R ) -7 - [( R ) -2-amino-2-phenylacetamido] -3-chloro-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-en- 2-carboxylic acid; Losefar; Distaclor; Cephaclor;
Molecular formula	C 15 H 14 ClN 3 O 4 S
External identifiers / databases
EC number	258-909-5
ECHA InfoCard	100.053.536
PubChem	51039
ChemSpider	46260
DrugBank	DB00833
Wikidata	Q415167
properties
Molar mass	367.81 g mol −1
solubility	soluble in hydrochloric acid (1 mol·l −1 )
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 317
	P: 280
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cefaclor is an antibiotic . It belongs to the second generation of the cephalosporins . Cefaclor is administered orally and can be used against gram-positive and gram-negative bacteria.

Side effects

Often allergic reactions, allergic neutropenia, phlebitis, gastrointestinal complaints
Occasionally increased transaminases and alkaline phosphatase, changes in the blood count, dizziness, hypertension
Rarely, pesudomembranous colitis
Very rarely lymphocytosis, leukopenia, hepatitis, cholestasis

Contraindications

Cefaclor is contraindicated in cephalosporin allergy. Because of the risk of cross allergy, the drug should be used with caution in the case of penicillin allergy.

Web links

Entry on Cefaclor in Pharmawiki

Individual evidence

↑ ^a ^b ^c data sheet Cefaclor from Sigma-Aldrich , accessed on December 30, 2011 ( PDF ).
^ Marianne Abele-Horn: Antimicrobial Therapy. Decision support for the treatment and prophylaxis of infectious diseases. With the collaboration of Werner Heinz, Hartwig Klinker, Johann Schurz and August Stich, 2nd, revised and expanded edition. Peter Wiehl, Marburg 2009, ISBN 978-3-927219-14-4 , p. 339.

[Sigma-1] ta sheet Cefaclor from Sigma-Aldrich , accessed on December 30, 2011 ( PDF ).

[2] Marianne Abele-Horn: Antimicrobial Therapy. Decision support for the treatment and prophylaxis of infectious diseases. With the collaboration of Werner Heinz, Hartwig Klinker, Johann Schurz and August Stich, 2nd, revised and expanded edition. Peter Wiehl, Marburg 2009, ISBN 978-3-927219-14-4 , p. 339.