Christian Büchel

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Christian Büchel (born December 14, 1965 ) is a German physician and neuroscientist. He is Professor and Director of the Institute for Systemic Neurosciences at the University Medical Center Hamburg-Eppendorf (UKE).

Life

Büchel studied medicine at the University of Heidelberg from 1987 to 1993 , where he received his Dr. med. received his doctorate. In 1994/95 he was in the neurology department of the University of Essen for specialist training in neurology. From 1995 to 1999 he was a post-doctoral student with Richard Frackowiak in London and in 1998/99 in the neurology department of the University of Hamburg. Since 2000 he has headed a junior research group there and has been Professor and Head of the Department of Systematic Neurosciences there since 2005. He has also been Professor of Psychology in the Faculty of Psychology since 2005.

In 2011 he received the Ernst Jung Prize and the Gottfried Wilhelm Leibniz Prize . He is co-editor of the European Journal of Neuroscience and a member of the Hamburg Academy of Sciences.

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Büchel investigated how higher cognitive processes such as learning are anchored in functional connections in the brain. For example, he uses fMRI (functional MRI ) and various EEG techniques. He looked at the impact of emotions (such as fear, pain) on learning and memory and the brain's reward system.

With colleagues he showed that not only the explicit, but also implicit learning, as is generally assumed , is connected with the medial temporal lobe system, that the participation of the various brain areas in learning and in memory depends more on the nature of the objects to be learned and that the explicit ( Attention-related) access to memory is an independent process involving several different areas of the brain. In 1999 he and colleagues showed how different parts of the visual system of the brain work closely together in learning the spatial localization of objects.

He showed in studies of the effect of placebo - analgesics on pain perception that higher cognitive processes have influence on the level of the spinal cord, such as pain affects the perception. how smells strengthen memory and how pathological gambling addiction is caused by decreased activity in the mesolimbic system . The investigations of his group also concern other addiction phenomena. Together with colleagues, he demonstrated the role of the amygdala in fear conditioning. He also demonstrated an increased activation of the amygdala and its coupling to the ventromedial prefrontal cortex in test subjects with a genetic predisposition to depression (in the serotonin transporter gene SLC6A4). His group also found evidence of a genetic disposition for addiction risk from studies of brain activity in the prefrontal cortex and striatum , with the test subjects showing variations in the genes for enzymes linked to the dopamine system (DAT, COMT).

Web links

Individual evidence

  1. ↑ Michael Rose, Hilde Haider, Cornelius Weiller, Christian Büchel: The role of medial temporal lobe structures in implicit learning: an event-related fMRI study . In: Neuron , Volume 36, 2002, pp. 1221-1231
  2. ↑ M. Rose, H. Haider, C. Weiller, C. Büchel: The relevance of the nature of learned associations for the differentiation of human memory systems . In: Learning & Memory , Volume 11, 2004, pp. 145–152
  3. ^ Rose, Haider, Büchel: The Emergence of Explicit Memory during Learning . In: Cerebral Cortex , Volume 20, 2010, pp. 2787-2797
  4. ↑ C. Büchel, JT Coull, KJ Friston: The predictive value of changes in effective connectivity for human learning. In: Science , Volume 283, 1999, p. 1538
  5. ↑ F. Eippert, J. Finsterbusch, U. Bingel, C. Büchel: Direct evidence for spinal cord involvement in placeboanalgesia . In: Science , Volume 326, 2009, p. 404
  6. ↑ U. Bingel, M. Rose, J. Glascher, C. Büchel: FMRI reveals how pain modulates visual object processing in the ventral visual stream . In: Neuron , Volume 55, 2007, pp. 157-167
  7. ^ B. Rasch, C. Büchel, S. Gais, J. Born: Odor cues during slow-wave sleep prompt declarative memory consolidation . In: Science , Volume 315, 2007, pp. 1426-1429
  8. ↑ J. Reuter, T. Raedler, M. Rose, I. Hand, J. Glascher, C. Büchel: Pathological gambling is linked to reduced activation of the mesolimbic reward system . In: Nature Neuroscience , Volume 8, 2005, pp. 147-148
  9. ↑ Büchel, J. Morris, R. Dolan, K. Friston: Brain systems mediating aversive conditioning: an event related fMRI study . In: Neuron , Volume 20, 1998, pp. 947-957, Büchel, R. Dolan, J. Armony, K. Friston: Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event related functional magnetic resonance imaging . In: Journal of Neuroscience , Volume 19, 1999, pp. 10869-10876
  10. ↑ A. Heinz, DF Braus, M .N. Smolka, J. Wrase, I. Puls, D. Hermann, S. Klein, SM Grüsser, H. Flor, G. Schumann, K. Mann, C. Büchel: Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter . In: Nature Neuroscience , Volume 8, 2005, pp. 20-21, PMID 15592465
  11. ↑ Juliana Yacubian, Tobias Sommer, Katrin Schroeder, Jan Gläscher, Raffael Kalisch, Boris Leuenberger, Dieter F. Braus, Christian Büchel Gene-gene interaction associated with neural reward sensitivity . In: Proc. Natl. Acad. Sci. , Volume 104, 2007, pp. 8125-8130
personal data
SURNAME Büchel, Christian
BRIEF DESCRIPTION German medic
DATE OF BIRTH December 14, 1965