Clumping factor A
| Clumping factor A ( Staphylococcus aureus st. Newman) | ||
|---|---|---|
| Mass / length primary structure | 860 amino acids | |
| Identifier | ||
| Gene name (s) | clfA (KEGG) | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Staphylococcus aureus | |
The clumping factor A ( Clumpingfaktor A ) is a by certain bacteria , especially Staphylococcus aureus and other Staphylococcus formed strains protein that is localized on the cell surface.
function
It is a so-called fibrinogen - receptor , the individual fibrin (fibrin) in blood plasma activated by binding can. This leads to clumping of the blood plasma (plasma agglutination ), hence the name clumping factor. In addition, the clumping factor A binds specifically to fibrinogen, so that it belongs to the group of adhesins . Adhesins play an important role in the infection process. The clumping factor A is therefore an important virulence factor of Staphylococcus aureus .
Diagnostic significance
The clumping factor can be detected using various agglutination methods and can thus be used to diagnose an infection with Staphylococcus aureus . The activity of plasma coagulase and clumping factor A can be detected in the context of the coagulase reaction .
However, there are also coagulase-negative staphylococci , for example Staphylococcus lugdunensis , which form the clumping factor and, based on the test result , can be confused with S. aureus .
literature
- Werner Koehler u. a .: Medical microbiology . 8th edition. Urban & Fischer-Verlag, Munich 2001, ISBN 3-437-41640-5 (former title: Textbook of Medical Microbiology ).
Individual evidence
- ↑ Homologues at OMA
- ↑ Jean Freney, Yvonne Brun, Michele Bes, Helene Meugnier, Francine Grimont, Patrick AD Grimont, Chantal Nervi, Jean Fleurette: Staphylococcus lugdunensis sp. nov. and Staphylococcus schleiferi sp. nov., Two Species from Human Clinical Specimens . In: International Journal of Systematic Bacteriology . tape 38 , no. 2 , April 1988, pp. 168-172 , doi : 10.1099 / 00207713-38-2-168 .