Dermatochalasis
| Classification according to ICD-10 | |
|---|---|
| Q82.8 | Other specified congenital malformations of the skin - cutis laxa (hyperelastica) |
| H02.3 | Blepharochalasis |
| L57.4 | Cutis laxa senilis |
| ICD-10 online (WHO version 2019) | |
The dermatochalasis (from the Greek δέρμα derma "skin" and χαλασις chalasis "slackening". Synonym: Latin cutis laxa = "sagging skin") 'describes a group of mostly age-related connective tissue changes , often with familial accumulation. The term is often used in ophthalmology , but also in dermatology . A common characteristic is sagging, inelastic skin on different parts of the body that often sags in large folds, which makes the person concerned look older. Well-known manifestations can be found on the bags under the eyes , the eyelids or the skin on the back .
causes
Possible causes are:
- idiopathic recurrent swelling of the upper eyelids ( blepharochalasis )
- Hereditary diseases of the connective tissue ( cutis laxa syndrome )
- in the context of rare syndromes such as Ascher syndrome
- age-related ( Cutis laxa senilis )
- acquired by inflammatory skin diseases ( dermatitis ) or by taking penicillamine during pregnancy ( cutis laxa acquisita )
diagnosis
The differentiation of the different forms is based on the age of onset, any previous changes such as urticaria , Quincke's edema , inflammatory skin changes or allergic reactions, for example to drugs. If a hereditary form is suspected, a detailed physical examination with a family history , possibly diagnostic imaging and, if necessary, further examinations must be carried out.
Differential diagnosis
The following are also to be distinguished:
- Ehlers-Danlos Syndrome
- Williams-Beuren Syndrome
- Pseudoxanthoma elasticum
- Progeria (Hutchinson-Gilford syndrome)
- Barber-Say Syndrome
- Costello syndrome
- Cardio-Facio-Cutaneous Syndrome
- Kabuki syndrome
therapy
Depending on the cause of the disease, there are different treatment approaches, such as conservative measures that tighten the skin (gymnastics, cold-warm showers, connective tissue massages, etc.) or surgical interventions (e.g. blepharoplasty). In the case of acquired forms, the focus is on the therapy of the underlying disease.
literature
- H. Mensing, T. Krieg, W. Meigel, O. Braun-Falco: Cutis laxa. Classification, Clinical Aspects and Molecular Defects. In: The dermatologist ; Journal of Dermatology, Venereology, and Allied Fields. Volume 35, No. 10, October 1984, pp. 506-511, PMID 6500933 .
- M. Mohamed, M. Voet, T. Gardeitchik, E. Morava: Cutis Laxa. In: Advances in Experimental Medicine and Biology . Volume 802, 2014, pp. 161-184, doi : 10.1007 / 978-94-007-7893-1_11 , PMID 24443027 (review).
- E. Makrantonaki, CC Zouboulis: Molecular Etiology of Skin Aging . In: The dermatologist ; Journal of Dermatology, Venereology, and Allied Fields. Volume 62, No. 8, August 2011, pp. 582-587, doi: 10.1007 / s00105-011-2136-7 , PMID 21681542 (review).
Web links
- Definition of dermatochalasis. DermIS
- P. Altmeyer: Cutis laxa . In: Encyclopedia of Dermatology, Allergology, Environmental Medicine
- Statement by the DOG Ophthalmoplastic and Reconstructive Surgery Section (SORC) on the distinction between functional surgical indications and aesthetic indications in blepharoplasty (PDF) German Ophthalmological Society (DOG)
Individual evidence
- ↑ Anselm Kampik, Franz Grehn: Ophthalmological differential diagnosis . Georg Thieme, 2008, ISBN 978-3-13-156782-6 .
- ↑ a b Peter Altmeyer, V. Paech: Therapy Glossary Dermatology and Allergy . Springer, 2005, ISBN 978-3-540-27648-7 .
- ↑ a b c Dermatochalasis. In: Orphanet (Rare Disease Database).
- ^ Institute for Medical Genetics and Human Genetics at Charité Berlin: Hereditary diseases of connective tissue
- ↑ O. Braun-Falco, M. Rupec, MJ Lindley: Congenital dermatochalasis as a key symptom of a symptom complex . In: Archives for Clinical and Experimental Dermatology . tape 220 , no. 2 , March 1964, p. 166-182 , doi : 10.1007 / BF00571834 .
