Döhle bodies
Döhle bodies are light blue-gray, oval-shaped, basophilic inclusion bodies in the protoplasm of neutrophil granulocytes .
description
The diameter of the Döhle corpuscles is 1 to 3 µm . Not much is known about the formation of the Döhle corpuscles, but it is assumed that they are remnants of the rough endoplasmic reticulum caused by cell maturation disorders. The Döhle bodies can inter alia in the May-Hegglin anomaly , with burns and certain infections ( scarlet fever , typhus , pneumonia ), and the Chediak-Higashi syndrome diagnosed are.
Naming
The Döhle bodies are named after the Kiel pathologist Paul Döhle (1855–1928). He discovered them in 1911 in patients with scarlet fever.
Individual evidence
- ^ W. Weiner, E. Topley: Döhle bodies in the leucocytes of patients with burns. In: Journal of Clinical Pathology 8/1955, pp. 324-8. PMID 13271584 PMC 1023880 (free full text)
- ↑ P. Döhle: Leukocyte inclusions in scarlet fever. In: Zbl. Bakt. 61/1911, p. 63.
literature
- WT Cummins: The Leukocytic Inclusions of Döhlé. In: J Med Res 27/1913, pp. 529-40.
- JC Cawley, FG Hayhoe: The inclusions of the May-Hegglin anomaly and Döhle bodies of infection: an ultrastructural comparison. In: British Journal of Hematology 22/1972, pp. 491-6.
- HP Aquarius. Döhle Bodies in Bufo temporaria afflicted with 'Red Leg Disease'. In: Nature 202/1964, p. 816.
- JA Easton, C. Fessas: The incidence of Döhle bodies in various diseases and their association with thrombocytopenia. In: British Journal of Hematology 12/1966, pp. 54-60. PMID 5906269
- T. Itoga, J. Laszlo: Dohle bodies and other granulocytic alterations during chemotherapy with cyclophosphamide. In: Blood 20/1962, pp. 668-74. PMID 13957029 (with images of Döhle bodies)
- MR Abernathy: Döhle bodies associated with uncomplicated pregnancy. In: Blood 27/1966, pp. 380-5. PMID 5930802 (with images of Döhle bodies)