Depot drug form
Depot drug forms are drug forms in which the active ingredient is released through retardation over a longer period of time. In contrast to sustained-release medicament forms, depot medicament forms in the narrower sense are parenterally administered medicament forms which form a local depot, for example in muscle tissue or subcutaneously . But both terms are often used synonymously. One goal of the depot form is to achieve better patient compliance .
A distinction can be made between biodegradable and non-biodegradable depot drug forms. With the latter, the depot body must be removed mechanically after the end of therapy. Biodegradable deposits consist, for example, of liposomes and are broken down by the organism.
Well-known examples from the field of contraceptives for women are Implanon or the NuvaRing .
Biodegradable depot pharmaceuticals are, for example, the neuroleptics in depot galenics, such as haloperidol decanoate (trade name e.g. Haldol-Janssen decanoate), flupentixol decanoate (trade name e.g. Fluanxol depot), which are injected intramuscularly as lipophilic fatty acid esters in an injection solution in sterile oil (injection Muscle). The oily deposit formed during the injection is slowly and completely broken down by the body.
Individual evidence
- ↑ FachInfo-Service, as of May 2010
literature
- Kurt H. Bauer, Karl-Heinz Frömming, Claus Führer, Bernhardt C. Lippold: Textbook of Pharmaceutical Technology . 8th edition. Wissenschaftliche Verlagsgesellschaft, Stuttgart 2006, ISBN 3-80-472222-9 .
- Rudolf Voigt, Alfred Fahr : Pharmaceutical Technology . 9th edition. Deutscher Apotheker Verlag, Stuttgart 2006, ISBN 3-76-922649-6 .