Diacerein

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Structural formula
Structure of diacerein
General
Non-proprietary name Diacerein
other names
  • 4,5-diacetyloxy-9,10-dioxo-anthracene-2-carboxylic acid
  • 1,8-diacetoxy-3-carboxyanthraquinone
  • Diacetylrhein
  • Diacerhein
Molecular formula C 19 H 12 O 8
External identifiers / databases
CAS number 13739-02-1
EC number 237-310-2
ECHA InfoCard 100.033.904
PubChem 26248
Wikidata Q413178
Drug information
ATC code

M01 AX21

Drug class

Anti-inflammatory

Mechanism of action

Interleukin-1 inhibitor

properties
Molar mass 368.29 g mol −1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 315-319-335
P: 261-305 + 351 + 338
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Diacerein is the international non-proprietary name for the drug 1,8-diacetoxy-3-carboxyanthraquinone . Diacerein has an anti-inflammatory effect as an inhibitor of the cytokine interleukin-1 and is used as an active ingredient in some countries to treat osteoarthritis . A current study was able to demonstrate a slight pain reduction in hip arthrosis that is significant compared to a placebo .

Diacerein is diacetylated Rhine (see name), an anthranoid of the medicinal rhubarb root . The prodrug diacerein is deacetylated to Rhein in the liver and 30% is excreted via the kidneys . Unwanted side effects are mainly observed in the gastrointestinal tract, the active ingredient can lead to diarrhea .

Trade names

Verboril (A)

No drug with this active ingredient is currently approved in Germany.

Individual evidence

  1. ↑ a b Datasheet Diacerein at Sigma-Aldrich , accessed on March 24, 2011 ( PDF ).
  2. ^ TS Fidel et al.: Diacerein for osteoarthritis . In: Cochrane Database Syst Rev. 25 (2006), CD005117, PMID 16437519 .

literature

  • FR Althaus and HH Frey: Textbook of pharmacology and toxicology for veterinary medicine. Georg Thieme Verlag, 2007, ISBN 3-8304-1070-0 , p. 258 ( limited preview in the Google book search).
  • R. Hansel and O. Sticher: Pharmacognosie - Phytopharmazie. Verlag Springer, 2009, ISBN 3-642-00962-X , p. 1178ff ( limited preview in the Google book search).