Dietmar Vestweber

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Dietmar Vestweber (born March 16, 1956 in Wuppertal ) is a German biochemist and cell biologist. As its founding director, he established the Max Planck Institute for Molecular Biomedicine in Münster in 2001 . There he heads the “Vascular Cell Biology” department.

Live and act

After studying biochemistry at the Universities of Tübingen and Munich and at the Max Planck Institute for Biochemistry in Martinsried, Vestweber conducted research at the Max Planck Institute for Developmental Biology in Tübingen. After obtaining his doctorate in zoology (1985), he moved to the Biozentrum of the University of Basel as a postdoc , where he completed his habilitation in biochemistry in 1990.

In 1990 Vestweber took over the leadership of a research group at the Max Planck Institute for Immunobiology in Freiburg and in 1994 accepted a professorship for cell biology at the medical faculty of the University of Münster at the newly established Center for Molecular Biology of Inflammation (ZMBE).

In 1998, Dietmar Vestweber was appointed director of a department at what was then the Max Planck Institute for Physiological and Clinical Research in Bad Nauheim , which he accepted in 1999. After a two-year phase during which Vestweber worked at both institutes in Münster and Bad Nauheim, he took over the management of the newly founded Max Planck Institute for Molecular Biomedicine in Münster in 2001.

research

His research has spanned three different areas. In the course of his doctorate, he examined the molecular basis of cell recognition and cell-cell adhesion between epithelial cells and in the pre-implantation embryo of the mouse and carried out fundamental work on E-cadherin (then uvomorulin) in Rolf Kemler's group.

During his time as a postdoc in Gottfried Schatz's group at the Biozentrum, he researched the mechanisms of mitochondrial biogenesis and found the first component (now known as TOM40) of the mitochondrial transport machinery that mediates the transport of proteins into mitochondria.

Since 1990 he has been researching the regulation of inflammatory processes. Inflammatory processes lead to the migration of immune cells (leukocytes) from the blood into damaged or infected tissue. Vestweber's group investigates the mechanisms of cell recognition, cell adhesion and cell migration that control and mediate this process. At the moment the focus is on mechanisms that control the barrier function of the blood vessel wall and the endothelium of the blood vessels.

His approximately 250 publications have been cited over 14,000 times. His Hirsch index is 84 (as of July 2017).

Awards

Web links

Individual evidence

  1. ^ D Vestweber, R. Kemler. In: Exp Cell Res . , 1984 May, 152 (1), pp. 169-178, PMID 6370707 .
  2. ^ D Vestweber, J Brunner, A Baker, G. Schatz. In: Nature , 1989 Sep 21, 341 (6239), pp. 205-209, PMID 2674724 .
  3. ^ D Schulte, V Küppers, N Dartsch, A Broermann, H Li, A Zarbock, O Kamenyeva, F Kiefer, A Khandoga, S Massberg, D. Vestweber. In: EMBO J. , 2011 Aug 19, 30 (20), pp. 4157-4170, PMID 21857650 .
  4. ^ K Lühn, MK Wild, M Eckhardt, R Gerardy-Schahn, D. Vestweber. In: Nat Genet , 2001 May, 28 (1), pp. 69-72, PMID 11326279 .
  5. ↑ https://www.scopus.com/authid/detail.uri?authorId=55931259700
  6. ↑ Member entry by Prof. Dr. Dietmar Vestweber (with picture) at the German Academy of Sciences Leopoldina , accessed on June 28, 2016.


personal data
SURNAME Vestweber, Dietmar
BRIEF DESCRIPTION German biochemist and cell biologist
DATE OF BIRTH March 16, 1956
PLACE OF BIRTH Wuppertal